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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
POM121
Full Name:
Nuclear envelope pore membrane protein POM 121C
Alias:
Nuclear pore membrane protein 121-2; POM121-2
Type:
Nucleus, nuclear pore complex, membrane, Endoplasmic reticulum protein
Mass (Da):
125059
Number AA:
1229
UniProt ID:
A8CG34
International Prot ID:
IPI00032358
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005783
GO:0005643
GO:0005643
Uniprot
OncoNet
Molecular Function:
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0051028
GO:0015031
GO:0055085
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S2
_
_
_
_
_
_
M
S
P
A
A
A
A
A
G
Site 2
S19
E
R
R
R
P
I
A
S
V
R
D
G
R
G
R
Site 3
S70
T
A
A
W
W
G
L
S
R
E
P
R
G
S
R
Site 4
S76
L
S
R
E
P
R
G
S
R
P
L
S
S
F
V
Site 5
S80
P
R
G
S
R
P
L
S
S
F
V
Q
K
A
R
Site 6
S81
R
G
S
R
P
L
S
S
F
V
Q
K
A
R
H
Site 7
T91
Q
K
A
R
H
R
R
T
L
F
A
S
P
P
A
Site 8
S95
H
R
R
T
L
F
A
S
P
P
A
K
S
T
A
Site 9
S100
F
A
S
P
P
A
K
S
T
A
N
G
N
L
L
Site 10
T111
G
N
L
L
E
P
R
T
L
L
E
G
P
D
P
Site 11
S161
P
A
R
P
A
P
R
S
T
P
P
S
P
P
T
Site 12
T162
A
R
P
A
P
R
S
T
P
P
S
P
P
T
H
Site 13
S165
A
P
R
S
T
P
P
S
P
P
T
H
R
V
H
Site 14
T168
S
T
P
P
S
P
P
T
H
R
V
H
H
F
Y
Site 15
Y175
T
H
R
V
H
H
F
Y
P
S
L
P
T
P
L
Site 16
S177
R
V
H
H
F
Y
P
S
L
P
T
P
L
L
R
Site 17
T180
H
F
Y
P
S
L
P
T
P
L
L
R
P
S
G
Site 18
S186
P
T
P
L
L
R
P
S
G
R
P
S
P
R
D
Site 19
S190
L
R
P
S
G
R
P
S
P
R
D
R
G
T
L
Site 20
T196
P
S
P
R
D
R
G
T
L
P
D
R
F
V
I
Site 21
T204
L
P
D
R
F
V
I
T
P
R
R
R
Y
P
I
Site 22
Y209
V
I
T
P
R
R
R
Y
P
I
H
Q
T
Q
Y
Site 23
Y216
Y
P
I
H
Q
T
Q
Y
S
C
P
G
V
L
P
Site 24
S217
P
I
H
Q
T
Q
Y
S
C
P
G
V
L
P
T
Site 25
S237
Y
H
K
K
A
V
L
S
P
R
N
S
R
M
V
Site 26
S246
R
N
S
R
M
V
C
S
P
V
T
V
R
I
A
Site 27
S260
A
P
P
D
R
R
F
S
R
S
A
I
P
E
Q
Site 28
S262
P
D
R
R
F
S
R
S
A
I
P
E
Q
I
I
Site 29
S270
A
I
P
E
Q
I
I
S
S
T
L
S
S
P
S
Site 30
S271
I
P
E
Q
I
I
S
S
T
L
S
S
P
S
S
Site 31
T272
P
E
Q
I
I
S
S
T
L
S
S
P
S
S
N
Site 32
S274
Q
I
I
S
S
T
L
S
S
P
S
S
N
A
P
Site 33
S275
I
I
S
S
T
L
S
S
P
S
S
N
A
P
D
Site 34
S277
S
S
T
L
S
S
P
S
S
N
A
P
D
P
C
Site 35
S278
S
T
L
S
S
P
S
S
N
A
P
D
P
C
A
Site 36
S291
C
A
K
E
T
V
L
S
A
L
K
E
K
K
K
Site 37
S322
N
K
R
R
R
H
D
S
S
G
S
G
H
S
A
Site 38
S323
K
R
R
R
H
D
S
S
G
S
G
H
S
A
F
Site 39
S325
R
R
H
D
S
S
G
S
G
H
S
A
F
E
P
Site 40
S328
D
S
S
G
S
G
H
S
A
F
E
P
L
V
A
Site 41
S336
A
F
E
P
L
V
A
S
G
V
P
A
S
F
V
Site 42
S348
S
F
V
P
K
P
G
S
L
K
R
G
L
N
S
Site 43
S355
S
L
K
R
G
L
N
S
Q
S
S
D
D
H
L
Site 44
S357
K
R
G
L
N
S
Q
S
S
D
D
H
L
N
K
Site 45
S358
R
G
L
N
S
Q
S
S
D
D
H
L
N
K
R
Site 46
S366
D
D
H
L
N
K
R
S
R
S
S
S
M
S
S
Site 47
S368
H
L
N
K
R
S
R
S
S
S
M
S
S
L
T
Site 48
S369
L
N
K
R
S
R
S
S
S
M
S
S
L
T
G
Site 49
S370
N
K
R
S
R
S
S
S
M
S
S
L
T
G
A
Site 50
S372
R
S
R
S
S
S
M
S
S
L
T
G
A
Y
T
Site 51
S373
S
R
S
S
S
M
S
S
L
T
G
A
Y
T
S
Site 52
T375
S
S
S
M
S
S
L
T
G
A
Y
T
S
G
I
Site 53
Y378
M
S
S
L
T
G
A
Y
T
S
G
I
P
S
S
Site 54
T379
S
S
L
T
G
A
Y
T
S
G
I
P
S
S
S
Site 55
S380
S
L
T
G
A
Y
T
S
G
I
P
S
S
S
R
Site 56
S384
A
Y
T
S
G
I
P
S
S
S
R
N
A
I
T
Site 57
S385
Y
T
S
G
I
P
S
S
S
R
N
A
I
T
S
Site 58
S386
T
S
G
I
P
S
S
S
R
N
A
I
T
S
S
Site 59
T391
S
S
S
R
N
A
I
T
S
S
Y
S
S
T
R
Site 60
S392
S
S
R
N
A
I
T
S
S
Y
S
S
T
R
G
Site 61
S393
S
R
N
A
I
T
S
S
Y
S
S
T
R
G
I
Site 62
Y394
R
N
A
I
T
S
S
Y
S
S
T
R
G
I
S
Site 63
S395
N
A
I
T
S
S
Y
S
S
T
R
G
I
S
Q
Site 64
S396
A
I
T
S
S
Y
S
S
T
R
G
I
S
Q
L
Site 65
T397
I
T
S
S
Y
S
S
T
R
G
I
S
Q
L
W
Site 66
S401
Y
S
S
T
R
G
I
S
Q
L
W
K
R
N
G
Site 67
S410
L
W
K
R
N
G
P
S
S
S
P
F
S
S
P
Site 68
S411
W
K
R
N
G
P
S
S
S
P
F
S
S
P
A
Site 69
S412
K
R
N
G
P
S
S
S
P
F
S
S
P
A
S
Site 70
S415
G
P
S
S
S
P
F
S
S
P
A
S
S
R
S
Site 71
S416
P
S
S
S
P
F
S
S
P
A
S
S
R
S
Q
Site 72
S419
S
P
F
S
S
P
A
S
S
R
S
Q
T
P
E
Site 73
S420
P
F
S
S
P
A
S
S
R
S
Q
T
P
E
R
Site 74
S422
S
S
P
A
S
S
R
S
Q
T
P
E
R
P
A
Site 75
T424
P
A
S
S
R
S
Q
T
P
E
R
P
A
K
K
Site 76
S441
E
E
E
L
C
H
H
S
S
S
S
T
P
L
A
Site 77
S442
E
E
L
C
H
H
S
S
S
S
T
P
L
A
A
Site 78
S443
E
L
C
H
H
S
S
S
S
T
P
L
A
A
D
Site 79
S444
L
C
H
H
S
S
S
S
T
P
L
A
A
D
K
Site 80
T445
C
H
H
S
S
S
S
T
P
L
A
A
D
K
E
Site 81
S453
P
L
A
A
D
K
E
S
Q
G
E
K
A
A
D
Site 82
T462
G
E
K
A
A
D
T
T
P
R
K
K
Q
N
S
Site 83
S469
T
P
R
K
K
Q
N
S
N
S
Q
S
T
P
G
Site 84
S471
R
K
K
Q
N
S
N
S
Q
S
T
P
G
S
S
Site 85
S473
K
Q
N
S
N
S
Q
S
T
P
G
S
S
G
Q
Site 86
T474
Q
N
S
N
S
Q
S
T
P
G
S
S
G
Q
R
Site 87
S477
N
S
Q
S
T
P
G
S
S
G
Q
R
K
R
K
Site 88
S478
S
Q
S
T
P
G
S
S
G
Q
R
K
R
K
V
Site 89
S490
R
K
V
Q
L
L
P
S
R
R
G
E
Q
L
T
Site 90
T497
S
R
R
G
E
Q
L
T
L
P
P
P
P
Q
L
Site 91
S520
L
D
L
E
K
K
A
S
L
Q
W
F
N
Q
A
Site 92
S532
N
Q
A
L
E
D
K
S
D
A
A
S
N
S
V
Site 93
S536
E
D
K
S
D
A
A
S
N
S
V
T
E
T
P
Site 94
S538
K
S
D
A
A
S
N
S
V
T
E
T
P
P
T
Site 95
T540
D
A
A
S
N
S
V
T
E
T
P
P
T
T
Q
Site 96
T542
A
S
N
S
V
T
E
T
P
P
T
T
Q
P
S
Site 97
T545
S
V
T
E
T
P
P
T
T
Q
P
S
F
T
F
Site 98
T546
V
T
E
T
P
P
T
T
Q
P
S
F
T
F
T
Site 99
S549
T
P
P
T
T
Q
P
S
F
T
F
T
L
P
A
Site 100
S565
A
T
A
S
P
P
T
S
L
L
A
P
S
T
N
Site 101
S570
P
T
S
L
L
A
P
S
T
N
P
L
L
E
S
Site 102
S577
S
T
N
P
L
L
E
S
L
K
K
M
Q
T
P
Site 103
T583
E
S
L
K
K
M
Q
T
P
P
S
L
P
P
C
Site 104
S586
K
K
M
Q
T
P
P
S
L
P
P
C
P
E
S
Site 105
S593
S
L
P
P
C
P
E
S
A
G
A
A
T
T
E
Site 106
T599
E
S
A
G
A
A
T
T
E
A
L
S
P
P
K
Site 107
S603
A
A
T
T
E
A
L
S
P
P
K
T
P
S
L
Site 108
T607
E
A
L
S
P
P
K
T
P
S
L
L
P
P
L
Site 109
S619
P
P
L
G
L
S
Q
S
G
P
P
G
L
L
P
Site 110
S627
G
P
P
G
L
L
P
S
P
S
F
D
S
K
P
Site 111
S629
P
G
L
L
P
S
P
S
F
D
S
K
P
P
T
Site 112
S632
L
P
S
P
S
F
D
S
K
P
P
T
T
L
L
Site 113
T651
A
P
S
M
V
P
A
T
D
T
K
A
P
P
T
Site 114
T653
S
M
V
P
A
T
D
T
K
A
P
P
T
L
Q
Site 115
T670
T
A
T
K
P
Q
A
T
S
A
P
S
P
A
P
Site 116
S674
P
Q
A
T
S
A
P
S
P
A
P
K
Q
S
F
Site 117
S680
P
S
P
A
P
K
Q
S
F
L
F
G
T
Q
N
Site 118
T685
K
Q
S
F
L
F
G
T
Q
N
T
S
P
S
S
Site 119
T688
F
L
F
G
T
Q
N
T
S
P
S
S
P
A
A
Site 120
S689
L
F
G
T
Q
N
T
S
P
S
S
P
A
A
P
Site 121
S691
G
T
Q
N
T
S
P
S
S
P
A
A
P
A
A
Site 122
S692
T
Q
N
T
S
P
S
S
P
A
A
P
A
A
S
Site 123
S699
S
P
A
A
P
A
A
S
S
A
S
P
M
F
K
Site 124
S700
P
A
A
P
A
A
S
S
A
S
P
M
F
K
P
Site 125
S702
A
P
A
A
S
S
A
S
P
M
F
K
P
I
F
Site 126
T710
P
M
F
K
P
I
F
T
A
P
P
K
S
E
K
Site 127
S715
I
F
T
A
P
P
K
S
E
K
E
G
P
T
P
Site 128
T721
K
S
E
K
E
G
P
T
P
P
G
P
S
V
T
Site 129
S726
G
P
T
P
P
G
P
S
V
T
A
T
A
P
S
Site 130
T730
P
G
P
S
V
T
A
T
A
P
S
S
S
S
L
Site 131
S733
S
V
T
A
T
A
P
S
S
S
S
L
P
T
T
Site 132
S734
V
T
A
T
A
P
S
S
S
S
L
P
T
T
T
Site 133
S735
T
A
T
A
P
S
S
S
S
L
P
T
T
T
S
Site 134
S736
A
T
A
P
S
S
S
S
L
P
T
T
T
S
T
Site 135
T739
P
S
S
S
S
L
P
T
T
T
S
T
T
A
P
Site 136
T740
S
S
S
S
L
P
T
T
T
S
T
T
A
P
T
Site 137
S742
S
S
L
P
T
T
T
S
T
T
A
P
T
F
Q
Site 138
T743
S
L
P
T
T
T
S
T
T
A
P
T
F
Q
P
Site 139
T747
T
T
S
T
T
A
P
T
F
Q
P
V
F
S
S
Site 140
S753
P
T
F
Q
P
V
F
S
S
M
G
P
P
A
S
Site 141
T771
P
A
P
F
F
K
Q
T
T
T
P
A
T
A
P
Site 142
T773
P
F
F
K
Q
T
T
T
P
A
T
A
P
T
T
Site 143
T799
T
S
A
V
A
P
I
T
S
A
S
P
S
T
D
Site 144
S800
S
A
V
A
P
I
T
S
A
S
P
S
T
D
S
Site 145
S802
V
A
P
I
T
S
A
S
P
S
T
D
S
A
S
Site 146
S804
P
I
T
S
A
S
P
S
T
D
S
A
S
K
P
Site 147
T805
I
T
S
A
S
P
S
T
D
S
A
S
K
P
A
Site 148
S807
S
A
S
P
S
T
D
S
A
S
K
P
A
F
G
Site 149
S809
S
P
S
T
D
S
A
S
K
P
A
F
G
F
G
Site 150
S821
G
F
G
I
N
S
V
S
S
S
S
V
S
T
T
Site 151
S822
F
G
I
N
S
V
S
S
S
S
V
S
T
T
T
Site 152
S823
G
I
N
S
V
S
S
S
S
V
S
T
T
T
S
Site 153
S824
I
N
S
V
S
S
S
S
V
S
T
T
T
S
T
Site 154
S826
S
V
S
S
S
S
V
S
T
T
T
S
T
A
T
Site 155
T827
V
S
S
S
S
V
S
T
T
T
S
T
A
T
A
Site 156
T828
S
S
S
S
V
S
T
T
T
S
T
A
T
A
A
Site 157
S830
S
S
V
S
T
T
T
S
T
A
T
A
A
S
Q
Site 158
T870
K
P
P
A
L
P
T
T
T
T
V
T
T
F
S
Site 159
T872
P
A
L
P
T
T
T
T
V
T
T
F
S
Q
S
Site 160
T875
P
T
T
T
T
V
T
T
F
S
Q
S
L
P
T
Site 161
S905
F
G
S
T
L
A
T
S
A
P
A
T
S
S
Q
Site 162
T909
L
A
T
S
A
P
A
T
S
S
Q
P
T
L
T
Site 163
S911
T
S
A
P
A
T
S
S
Q
P
T
L
T
F
S
Site 164
T914
P
A
T
S
S
Q
P
T
L
T
F
S
N
T
S
Site 165
T916
T
S
S
Q
P
T
L
T
F
S
N
T
S
T
P
Site 166
S918
S
Q
P
T
L
T
F
S
N
T
S
T
P
T
F
Site 167
T920
P
T
L
T
F
S
N
T
S
T
P
T
F
N
I
Site 168
T922
L
T
F
S
N
T
S
T
P
T
F
N
I
P
F
Site 169
T924
F
S
N
T
S
T
P
T
F
N
I
P
F
G
S
Site 170
S931
T
F
N
I
P
F
G
S
S
A
K
S
P
L
P
Site 171
S932
F
N
I
P
F
G
S
S
A
K
S
P
L
P
S
Site 172
S935
P
F
G
S
S
A
K
S
P
L
P
S
Y
P
G
Site 173
S939
S
A
K
S
P
L
P
S
Y
P
G
A
N
P
Q
Site 174
Y940
A
K
S
P
L
P
S
Y
P
G
A
N
P
Q
P
Site 175
S971
L
T
P
S
F
G
S
S
F
T
F
G
N
S
A
Site 176
T973
P
S
F
G
S
S
F
T
F
G
N
S
A
A
P
Site 177
S977
S
S
F
T
F
G
N
S
A
A
P
A
P
A
T
Site 178
T1008
V
P
T
P
I
Q
P
T
F
G
G
A
T
H
S
Site 179
S1031
S
A
F
G
A
P
A
S
S
Q
P
A
F
G
G
Site 180
S1032
A
F
G
A
P
A
S
S
Q
P
A
F
G
G
S
Site 181
S1051
S
F
G
A
A
T
S
S
G
F
G
A
T
T
Q
Site 182
T1057
S
S
G
F
G
A
T
T
Q
T
A
S
S
G
S
Site 183
T1059
G
F
G
A
T
T
Q
T
A
S
S
G
S
S
S
Site 184
S1061
G
A
T
T
Q
T
A
S
S
G
S
S
S
S
V
Site 185
S1062
A
T
T
Q
T
A
S
S
G
S
S
S
S
V
F
Site 186
S1065
Q
T
A
S
S
G
S
S
S
S
V
F
G
S
T
Site 187
S1066
T
A
S
S
G
S
S
S
S
V
F
G
S
T
T
Site 188
S1067
A
S
S
G
S
S
S
S
V
F
G
S
T
T
P
Site 189
S1071
S
S
S
S
V
F
G
S
T
T
P
S
P
F
T
Site 190
T1073
S
S
V
F
G
S
T
T
P
S
P
F
T
F
G
Site 191
T1078
S
T
T
P
S
P
F
T
F
G
G
S
A
A
P
Site 192
S1108
S
A
T
T
G
A
F
S
F
G
A
G
Q
S
G
Site 193
S1114
F
S
F
G
A
G
Q
S
G
S
T
A
T
S
T
Site 194
S1116
F
G
A
G
Q
S
G
S
T
A
T
S
T
P
F
Site 195
T1119
G
Q
S
G
S
T
A
T
S
T
P
F
T
G
G
Site 196
S1120
Q
S
G
S
T
A
T
S
T
P
F
T
G
G
L
Site 197
T1121
S
G
S
T
A
T
S
T
P
F
T
G
G
L
G
Site 198
T1124
T
A
T
S
T
P
F
T
G
G
L
G
Q
N
A
Site 199
T1134
L
G
Q
N
A
L
G
T
T
G
Q
S
T
P
F
Site 200
S1147
P
F
A
F
N
V
G
S
T
T
E
S
K
P
V
Site 201
S1151
N
V
G
S
T
T
E
S
K
P
V
F
G
G
T
Site 202
T1158
S
K
P
V
F
G
G
T
A
T
P
T
F
G
Q
Site 203
T1160
P
V
F
G
G
T
A
T
P
T
F
G
Q
N
T
Site 204
T1162
F
G
G
T
A
T
P
T
F
G
Q
N
T
P
A
Site 205
T1167
T
P
T
F
G
Q
N
T
P
A
P
G
V
G
T
Site 206
T1174
T
P
A
P
G
V
G
T
S
G
S
S
L
S
F
Site 207
S1180
G
T
S
G
S
S
L
S
F
G
A
S
S
A
P
Site 208
S1205
G
S
A
A
P
S
F
S
I
G
A
G
S
K
T
Site 209
T1212
S
I
G
A
G
S
K
T
P
G
A
R
Q
R
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation