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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
A2ML1
Full Name:
Alpha-2-macroglobulin-like protein 1
Alias:
C3 and PZP-like alpha-2-macroglobulin domain-containing protein 9
Type:
Mass (Da):
161086
Number AA:
1454
UniProt ID:
A8K2U0
International Prot ID:
IPI00419215
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005576
GO:0005615
GO:0044421
Uniprot
OncoNet
Molecular Function:
GO:0004857
GO:0004866
GO:0004867
PhosphoSite+
KinaseNET
Biological Process:
GO:0050790
GO:0051336
GO:0052547
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S35
P
A
R
L
N
F
P
S
V
Q
K
V
C
L
D
Site 2
S44
Q
K
V
C
L
D
L
S
P
G
Y
S
D
V
K
Site 3
S48
L
D
L
S
P
G
Y
S
D
V
K
F
T
V
T
Site 4
T62
T
L
E
T
K
D
K
T
Q
K
L
L
E
Y
S
Site 5
S106
S
G
V
G
N
N
I
S
F
E
E
K
K
K
V
Site 6
T122
I
Q
R
Q
G
N
G
T
F
V
Q
T
D
K
P
Site 7
T126
G
N
G
T
F
V
Q
T
D
K
P
L
Y
T
P
Site 8
Y131
V
Q
T
D
K
P
L
Y
T
P
G
Q
Q
V
Y
Site 9
T132
Q
T
D
K
P
L
Y
T
P
G
Q
Q
V
Y
F
Site 10
Y138
Y
T
P
G
Q
Q
V
Y
F
R
I
V
T
M
D
Site 11
Y155
F
V
P
V
N
D
K
Y
S
M
V
E
L
Q
D
Site 12
S165
V
E
L
Q
D
P
N
S
N
R
I
A
Q
W
L
Site 13
T208
A
E
G
K
T
F
G
T
F
S
V
E
E
Y
V
Site 14
S210
G
K
T
F
G
T
F
S
V
E
E
Y
V
L
P
Site 15
S230
V
V
E
P
K
E
L
S
T
V
Q
E
S
F
L
Site 16
T231
V
E
P
K
E
L
S
T
V
Q
E
S
F
L
V
Site 17
Y246
K
I
C
C
R
Y
T
Y
G
K
P
M
L
G
A
Site 18
Y265
V
C
Q
K
A
N
T
Y
W
Y
R
E
V
E
R
Site 19
S283
P
D
K
C
R
N
L
S
G
Q
T
D
K
T
G
Site 20
T289
L
S
G
Q
T
D
K
T
G
C
F
S
A
P
V
Site 21
T330
T
G
V
E
A
N
A
T
Q
N
I
Y
I
S
P
Site 22
Y334
A
N
A
T
Q
N
I
Y
I
S
P
Q
M
G
S
Site 23
S336
A
T
Q
N
I
Y
I
S
P
Q
M
G
S
M
T
Site 24
T343
S
P
Q
M
G
S
M
T
F
E
D
T
S
N
F
Site 25
Y351
F
E
D
T
S
N
F
Y
H
P
N
F
P
F
S
Site 26
S358
Y
H
P
N
F
P
F
S
G
K
I
R
V
R
G
Site 27
S369
R
V
R
G
H
D
D
S
F
L
K
N
H
L
V
Site 28
T402
N
N
G
L
A
P
F
T
L
E
T
S
G
W
N
Site 29
Y426
F
Q
M
E
D
L
V
Y
N
P
E
Q
V
P
R
Site 30
Y434
N
P
E
Q
V
P
R
Y
Y
Q
N
A
Y
L
H
Site 31
Y435
P
E
Q
V
P
R
Y
Y
Q
N
A
Y
L
H
L
Site 32
Y439
P
R
Y
Y
Q
N
A
Y
L
H
L
R
P
F
Y
Site 33
Y446
Y
L
H
L
R
P
F
Y
S
T
T
R
S
F
L
Site 34
S447
L
H
L
R
P
F
Y
S
T
T
R
S
F
L
G
Site 35
T448
H
L
R
P
F
Y
S
T
T
R
S
F
L
G
I
Site 36
S451
P
F
Y
S
T
T
R
S
F
L
G
I
H
R
L
Site 37
Y474
P
Q
E
V
L
V
D
Y
Y
I
D
P
A
D
A
Site 38
Y475
Q
E
V
L
V
D
Y
Y
I
D
P
A
D
A
S
Site 39
S482
Y
I
D
P
A
D
A
S
P
D
Q
E
I
S
F
Site 40
S488
A
S
P
D
Q
E
I
S
F
S
Y
Y
L
I
G
Site 41
S490
P
D
Q
E
I
S
F
S
Y
Y
L
I
G
K
G
Site 42
Y491
D
Q
E
I
S
F
S
Y
Y
L
I
G
K
G
S
Site 43
Y492
Q
E
I
S
F
S
Y
Y
L
I
G
K
G
S
L
Site 44
S498
Y
Y
L
I
G
K
G
S
L
V
M
E
G
Q
K
Site 45
S509
E
G
Q
K
H
L
N
S
K
K
K
G
L
K
A
Site 46
S517
K
K
K
G
L
K
A
S
F
S
L
S
L
T
F
Site 47
S563
M
C
F
D
N
Q
V
S
L
G
F
S
P
S
Q
Site 48
S567
N
Q
V
S
L
G
F
S
P
S
Q
Q
L
P
G
Site 49
S569
V
S
L
G
F
S
P
S
Q
Q
L
P
G
A
E
Site 50
S608
L
R
P
D
R
E
L
S
N
R
S
V
Y
G
M
Site 51
Y613
E
L
S
N
R
S
V
Y
G
M
F
P
F
W
Y
Site 52
S654
D
P
M
P
Q
G
H
S
S
Q
R
S
I
I
W
Site 53
S655
P
M
P
Q
G
H
S
S
Q
R
S
I
I
W
R
Site 54
S658
Q
G
H
S
S
Q
R
S
I
I
W
R
P
S
F
Site 55
S664
R
S
I
I
W
R
P
S
F
S
E
G
T
D
L
Site 56
S666
I
I
W
R
P
S
F
S
E
G
T
D
L
F
S
Site 57
T669
R
P
S
F
S
E
G
T
D
L
F
S
F
F
R
Site 58
S673
S
E
G
T
D
L
F
S
F
F
R
D
V
G
L
Site 59
S684
D
V
G
L
K
I
L
S
N
A
K
I
K
K
P
Site 60
S695
I
K
K
P
V
D
C
S
H
R
S
P
E
Y
S
Site 61
S698
P
V
D
C
S
H
R
S
P
E
Y
S
T
A
M
Site 62
Y701
C
S
H
R
S
P
E
Y
S
T
A
M
G
A
G
Site 63
S702
S
H
R
S
P
E
Y
S
T
A
M
G
A
G
G
Site 64
S717
G
H
P
E
A
F
E
S
S
T
P
L
H
Q
A
Site 65
T719
P
E
A
F
E
S
S
T
P
L
H
Q
A
E
D
Site 66
S727
P
L
H
Q
A
E
D
S
Q
V
R
Q
Y
L
P
Site 67
Y732
E
D
S
Q
V
R
Q
Y
L
P
E
T
W
L
W
Site 68
S771
K
A
M
S
F
C
T
S
Q
S
R
G
F
G
L
Site 69
S773
M
S
F
C
T
S
Q
S
R
G
F
G
L
S
P
Site 70
T809
R
G
E
S
F
R
L
T
A
T
I
F
N
Y
L
Site 71
T824
K
D
C
I
R
V
Q
T
D
L
A
K
S
H
E
Site 72
S829
V
Q
T
D
L
A
K
S
H
E
Y
Q
L
E
S
Site 73
S836
S
H
E
Y
Q
L
E
S
W
A
D
S
Q
T
S
Site 74
S840
Q
L
E
S
W
A
D
S
Q
T
S
S
C
L
C
Site 75
T842
E
S
W
A
D
S
Q
T
S
S
C
L
C
A
D
Site 76
S844
W
A
D
S
Q
T
S
S
C
L
C
A
D
E
A
Site 77
S871
G
H
I
N
F
T
I
S
T
K
I
L
D
S
N
Site 78
S877
I
S
T
K
I
L
D
S
N
E
P
C
G
G
Q
Site 79
T896
P
Q
K
G
R
S
D
T
L
I
K
P
V
L
V
Site 80
S926
C
P
K
G
K
V
A
S
E
S
V
S
L
E
L
Site 81
S928
K
G
K
V
A
S
E
S
V
S
L
E
L
P
V
Site 82
S968
D
G
L
V
Q
M
P
S
G
C
G
E
Q
N
M
Site 83
Y1010
V
G
F
L
E
I
G
Y
Q
K
E
L
M
Y
K
Site 84
Y1016
G
Y
Q
K
E
L
M
Y
K
H
S
N
G
S
Y
Site 85
S1019
K
E
L
M
Y
K
H
S
N
G
S
Y
S
A
F
Site 86
S1022
M
Y
K
H
S
N
G
S
Y
S
A
F
G
E
R
Site 87
Y1023
Y
K
H
S
N
G
S
Y
S
A
F
G
E
R
D
Site 88
S1127
G
L
W
C
L
K
N
S
A
T
S
T
T
N
L
Site 89
T1131
L
K
N
S
A
T
S
T
T
N
L
Y
T
Q
A
Site 90
Y1172
I
I
S
G
E
S
I
Y
W
S
Q
K
P
T
P
Site 91
S1174
S
G
E
S
I
Y
W
S
Q
K
P
T
P
S
S
Site 92
T1178
I
Y
W
S
Q
K
P
T
P
S
S
N
A
S
P
Site 93
S1180
W
S
Q
K
P
T
P
S
S
N
A
S
P
W
S
Site 94
S1181
S
Q
K
P
T
P
S
S
N
A
S
P
W
S
E
Site 95
S1184
P
T
P
S
S
N
A
S
P
W
S
E
P
A
A
Site 96
S1187
S
S
N
A
S
P
W
S
E
P
A
A
V
D
V
Site 97
T1206
Y
A
L
L
A
Q
L
T
K
P
S
L
T
Q
K
Site 98
Y1232
L
A
K
Q
R
N
A
Y
G
G
F
S
S
T
Q
Site 99
Y1256
A
K
Y
A
T
T
A
Y
V
P
S
E
E
I
N
Site 100
S1268
E
I
N
L
V
V
K
S
T
E
N
F
Q
R
T
Site 101
T1275
S
T
E
N
F
Q
R
T
F
N
I
Q
S
V
N
Site 102
T1290
R
L
V
F
Q
Q
D
T
L
P
N
V
P
G
M
Site 103
T1299
P
N
V
P
G
M
Y
T
L
E
A
S
G
Q
G
Site 104
T1322
R
Y
N
I
L
P
P
T
N
M
K
T
F
S
L
Site 105
S1328
P
T
N
M
K
T
F
S
L
S
V
E
I
G
K
Site 106
S1330
N
M
K
T
F
S
L
S
V
E
I
G
K
A
R
Site 107
T1342
K
A
R
C
E
Q
P
T
S
P
R
S
L
T
L
Site 108
S1343
A
R
C
E
Q
P
T
S
P
R
S
L
T
L
T
Site 109
S1346
E
Q
P
T
S
P
R
S
L
T
L
T
I
H
T
Site 110
T1348
P
T
S
P
R
S
L
T
L
T
I
H
T
S
Y
Site 111
T1350
S
P
R
S
L
T
L
T
I
H
T
S
Y
V
G
Site 112
S1354
L
T
L
T
I
H
T
S
Y
V
G
S
R
S
S
Site 113
Y1355
T
L
T
I
H
T
S
Y
V
G
S
R
S
S
S
Site 114
S1358
I
H
T
S
Y
V
G
S
R
S
S
S
N
M
A
Site 115
S1360
T
S
Y
V
G
S
R
S
S
S
N
M
A
I
V
Site 116
S1361
S
Y
V
G
S
R
S
S
S
N
M
A
I
V
E
Site 117
S1376
V
K
M
L
S
G
F
S
P
M
E
G
T
N
Q
Site 118
T1381
G
F
S
P
M
E
G
T
N
Q
L
L
L
Q
Q
Site 119
T1400
K
V
E
F
G
T
D
T
L
N
I
Y
L
D
E
Site 120
Y1404
G
T
D
T
L
N
I
Y
L
D
E
L
I
K
N
Site 121
T1416
I
K
N
T
Q
T
Y
T
F
T
I
S
Q
S
V
Site 122
Y1438
A
T
I
K
V
Y
D
Y
Y
L
P
D
E
Q
A
Site 123
Y1439
T
I
K
V
Y
D
Y
Y
L
P
D
E
Q
A
T
Site 124
Y1449
D
E
Q
A
T
I
Q
Y
S
D
P
C
E
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation