KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
ERI2
Full Name:
ERI1 exoribonuclease 2
Alias:
Exonuclease domain-containing protein 1
Type:
Mass (Da):
77401
Number AA:
691
UniProt ID:
A8K979
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S17
L
G
L
I
R
R
K
S
I
A
P
A
N
G
N
Site 2
S28
A
N
G
N
L
G
R
S
K
S
K
Q
L
F
D
Site 3
S30
G
N
L
G
R
S
K
S
K
Q
L
F
D
Y
L
Site 4
S75
T
S
T
G
Q
I
D
S
E
F
Q
A
Y
V
Q
Site 5
Y80
I
D
S
E
F
Q
A
Y
V
Q
P
Q
E
H
P
Site 6
S90
P
Q
E
H
P
I
L
S
E
F
C
M
E
L
T
Site 7
S140
A
T
G
I
S
E
P
S
A
S
E
V
K
L
C
Site 8
Y163
D
L
G
V
C
L
E
Y
E
C
K
R
K
Q
L
Site 9
T185
S
W
I
D
L
R
A
T
Y
K
L
F
Y
R
R
Site 10
Y186
W
I
D
L
R
A
T
Y
K
L
F
Y
R
R
K
Site 11
Y190
R
A
T
Y
K
L
F
Y
R
R
K
P
K
G
L
Site 12
S209
Q
E
V
G
I
E
F
S
G
R
E
H
S
G
L
Site 13
S214
E
F
S
G
R
E
H
S
G
L
D
D
S
R
N
Site 14
S219
E
H
S
G
L
D
D
S
R
N
T
A
L
L
A
Site 15
T222
G
L
D
D
S
R
N
T
A
L
L
A
W
K
M
Site 16
S241
C
V
M
K
I
T
R
S
L
N
K
V
P
T
K
Site 17
T247
R
S
L
N
K
V
P
T
K
K
N
F
S
I
L
Site 18
S302
M
K
S
I
C
A
N
S
P
I
K
A
Q
Q
D
Site 19
S320
V
K
N
N
I
K
A
S
L
H
N
V
K
S
S
Site 20
S326
A
S
L
H
N
V
K
S
S
L
P
L
F
N
T
Site 21
S327
S
L
H
N
V
K
S
S
L
P
L
F
N
T
K
Site 22
T333
S
S
L
P
L
F
N
T
K
S
S
T
S
V
G
Site 23
S335
L
P
L
F
N
T
K
S
S
T
S
V
G
Q
L
Site 24
S336
P
L
F
N
T
K
S
S
T
S
V
G
Q
L
Q
Site 25
S338
F
N
T
K
S
S
T
S
V
G
Q
L
Q
S
P
Site 26
S344
T
S
V
G
Q
L
Q
S
P
T
L
N
S
P
I
Site 27
T346
V
G
Q
L
Q
S
P
T
L
N
S
P
I
Y
M
Site 28
S349
L
Q
S
P
T
L
N
S
P
I
Y
M
Q
K
Q
Site 29
Y352
P
T
L
N
S
P
I
Y
M
Q
K
Q
G
K
N
Site 30
S368
H
L
A
F
N
T
K
S
K
A
S
T
V
G
S
Site 31
T372
N
T
K
S
K
A
S
T
V
G
S
E
L
V
L
Site 32
S391
V
P
T
V
H
H
V
S
D
L
E
M
S
S
T
Site 33
S417
D
V
V
L
L
P
A
S
Q
P
E
E
N
V
D
Site 34
T426
P
E
E
N
V
D
C
T
V
P
I
S
D
S
D
Site 35
S437
S
D
S
D
L
E
I
S
F
N
S
G
E
R
L
Site 36
S453
V
L
K
E
L
E
M
S
S
H
E
N
F
G
D
Site 37
S454
L
K
E
L
E
M
S
S
H
E
N
F
G
D
I
Site 38
T464
N
F
G
D
I
E
E
T
P
Q
K
S
E
T
S
Site 39
S468
I
E
E
T
P
Q
K
S
E
T
S
K
S
I
V
Site 40
S473
Q
K
S
E
T
S
K
S
I
V
Y
K
S
P
H
Site 41
Y476
E
T
S
K
S
I
V
Y
K
S
P
H
T
T
I
Site 42
S478
S
K
S
I
V
Y
K
S
P
H
T
T
I
Y
N
Site 43
Y484
K
S
P
H
T
T
I
Y
N
V
K
E
A
K
D
Site 44
S494
K
E
A
K
D
P
G
S
D
I
S
A
F
K
L
Site 45
S497
K
D
P
G
S
D
I
S
A
F
K
L
P
E
H
Site 46
S506
F
K
L
P
E
H
K
S
S
T
F
N
R
V
N
Site 47
S507
K
L
P
E
H
K
S
S
T
F
N
R
V
N
A
Site 48
T508
L
P
E
H
K
S
S
T
F
N
R
V
N
A
N
Site 49
S529
L
G
K
H
P
L
L
S
G
G
T
K
R
N
P
Site 50
S538
G
T
K
R
N
P
C
S
P
Q
A
F
P
P
A
Site 51
T558
T
I
H
E
E
K
P
T
S
S
D
C
S
P
V
Site 52
S559
I
H
E
E
K
P
T
S
S
D
C
S
P
V
R
Site 53
S560
H
E
E
K
P
T
S
S
D
C
S
P
V
R
S
Site 54
S563
K
P
T
S
S
D
C
S
P
V
R
S
S
S
W
Site 55
S567
S
D
C
S
P
V
R
S
S
S
W
R
R
L
P
Site 56
S568
D
C
S
P
V
R
S
S
S
W
R
R
L
P
S
Site 57
S569
C
S
P
V
R
S
S
S
W
R
R
L
P
S
I
Site 58
S575
S
S
W
R
R
L
P
S
I
L
T
S
T
V
N
Site 59
T578
R
R
L
P
S
I
L
T
S
T
V
N
L
Q
E
Site 60
S579
R
L
P
S
I
L
T
S
T
V
N
L
Q
E
P
Site 61
S589
N
L
Q
E
P
W
K
S
G
K
M
T
P
P
L
Site 62
T593
P
W
K
S
G
K
M
T
P
P
L
C
K
C
G
Site 63
S603
L
C
K
C
G
R
R
S
K
R
L
V
V
S
N
Site 64
S609
R
S
K
R
L
V
V
S
N
N
G
P
N
H
G
Site 65
Y620
P
N
H
G
K
V
F
Y
C
C
P
I
G
K
Y
Site 66
S650
L
Q
K
E
R
A
N
S
M
V
P
S
H
S
T
Site 67
S654
R
A
N
S
M
V
P
S
H
S
T
G
G
L
T
Site 68
S656
N
S
M
V
P
S
H
S
T
G
G
L
T
F
S
Site 69
T661
S
H
S
T
G
G
L
T
F
S
S
P
E
T
S
Site 70
S663
S
T
G
G
L
T
F
S
S
P
E
T
S
H
I
Site 71
S664
T
G
G
L
T
F
S
S
P
E
T
S
H
I
C
Site 72
T667
L
T
F
S
S
P
E
T
S
H
I
C
D
R
N
Site 73
S668
T
F
S
S
P
E
T
S
H
I
C
D
R
N
L
Site 74
S676
H
I
C
D
R
N
L
S
I
S
T
K
N
S
L
Site 75
S678
C
D
R
N
L
S
I
S
T
K
N
S
L
R
L
Site 76
S682
L
S
I
S
T
K
N
S
L
R
L
R
P
S
M
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation