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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
Rho guanine nucleotide exchange factor 33
Full Name:
Rho guanine nucleotide exchange factor 33
Alias:
Type:
Mass (Da):
42066
Number AA:
366
UniProt ID:
A8MVX0
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S9
S
M
I
Q
A
I
T
S
K
Q
E
E
M
Q
Q
Site 2
S29
Q
Q
E
K
R
R
E
S
R
K
V
K
A
K
K
Site 3
T37
R
K
V
K
A
K
K
T
Q
K
E
E
H
S
S
Site 4
S44
T
Q
K
E
E
H
S
S
Q
A
G
P
A
Q
A
Site 5
S54
G
P
A
Q
A
Q
G
S
P
F
R
S
I
N
I
Site 6
S58
A
Q
G
S
P
F
R
S
I
N
I
P
E
P
V
Site 7
T72
V
L
P
S
E
D
F
T
N
L
L
P
S
Q
A
Site 8
S77
D
F
T
N
L
L
P
S
Q
A
Y
E
K
A
Q
Site 9
S88
E
K
A
Q
E
S
R
S
V
H
V
G
D
S
N
Site 10
S94
R
S
V
H
V
G
D
S
N
V
K
G
M
M
G
Site 11
T108
G
P
G
V
N
P
T
T
P
E
A
E
E
N
L
Site 12
S117
E
A
E
E
N
L
K
S
C
L
S
A
D
I
Q
Site 13
S120
E
N
L
K
S
C
L
S
A
D
I
Q
S
K
G
Site 14
S125
C
L
S
A
D
I
Q
S
K
G
H
L
P
S
G
Site 15
S131
Q
S
K
G
H
L
P
S
G
M
W
R
Q
P
K
Site 16
Y147
G
K
E
W
G
E
E
Y
V
T
K
D
H
P
D
Site 17
T149
E
W
G
E
E
Y
V
T
K
D
H
P
D
K
L
Site 18
S165
E
A
G
Q
G
R
H
S
S
L
E
N
V
L
C
Site 19
S166
A
G
Q
G
R
H
S
S
L
E
N
V
L
C
E
Site 20
S175
E
N
V
L
C
E
T
S
L
A
A
K
R
Q
T
Site 21
T207
L
I
L
K
I
K
A
T
F
Q
G
S
D
G
K
Site 22
S217
G
S
D
G
K
R
N
S
K
E
R
S
L
F
P
Site 23
S221
K
R
N
S
K
E
R
S
L
F
P
G
S
L
R
Site 24
S226
E
R
S
L
F
P
G
S
L
R
Y
L
V
Q
Q
Site 25
Y229
L
F
P
G
S
L
R
Y
L
V
Q
Q
H
L
D
Site 26
T262
G
D
L
F
L
K
L
T
N
D
E
N
N
F
L
Site 27
Y271
D
E
N
N
F
L
D
Y
Y
V
A
Y
L
R
D
Site 28
Y272
E
N
N
F
L
D
Y
Y
V
A
Y
L
R
D
L
Site 29
S300
E
G
D
E
E
I
K
S
D
I
Y
T
L
F
F
Site 30
Y334
T
E
Q
E
H
P
D
Y
Y
L
L
L
V
C
V
Site 31
Y335
E
Q
E
H
P
D
Y
Y
L
L
L
V
C
V
Q
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation