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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
CAPN14
Full Name:
Calpain-14
Alias:
Calcium-activated neutral proteinase 14
Type:
Mass (Da):
79568
Number AA:
684
UniProt ID:
A8MX76
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y17
R
W
K
L
A
P
R
Y
S
R
R
A
S
P
Q
Site 2
S18
W
K
L
A
P
R
Y
S
R
R
A
S
P
Q
Q
Site 3
S22
P
R
Y
S
R
R
A
S
P
Q
Q
P
Q
Q
D
Site 4
T47
N
G
C
L
F
E
D
T
S
F
P
A
T
L
S
Site 5
S48
G
C
L
F
E
D
T
S
F
P
A
T
L
S
S
Site 6
T52
E
D
T
S
F
P
A
T
L
S
S
I
G
S
G
Site 7
S79
K
R
P
P
E
L
H
S
N
P
Q
F
Y
F
A
Site 8
Y84
L
H
S
N
P
Q
F
Y
F
A
K
A
K
R
L
Site 9
S126
R
V
V
P
L
N
Q
S
F
T
E
K
Y
A
G
Site 10
Y131
N
Q
S
F
T
E
K
Y
A
G
I
F
R
F
W
Site 11
Y182
G
A
L
L
E
K
A
Y
A
K
L
S
G
S
Y
Site 12
S186
E
K
A
Y
A
K
L
S
G
S
Y
E
D
L
Q
Site 13
S188
A
Y
A
K
L
S
G
S
Y
E
D
L
Q
S
G
Site 14
S194
G
S
Y
E
D
L
Q
S
G
Q
V
S
E
A
L
Site 15
S198
D
L
Q
S
G
Q
V
S
E
A
L
V
D
F
T
Site 16
T239
R
T
L
I
G
C
Q
T
H
S
G
E
K
I
L
Site 17
S241
L
I
G
C
Q
T
H
S
G
E
K
I
L
E
N
Site 18
Y256
G
L
V
E
G
H
A
Y
T
L
T
G
I
R
K
Site 19
T259
E
G
H
A
Y
T
L
T
G
I
R
K
V
T
C
Site 20
T265
L
T
G
I
R
K
V
T
C
K
H
R
P
E
Y
Site 21
Y272
T
C
K
H
R
P
E
Y
L
V
K
L
R
N
P
Site 22
S290
V
E
W
K
G
D
W
S
D
S
S
S
K
W
E
Site 23
S292
W
K
G
D
W
S
D
S
S
S
K
W
E
L
L
Site 24
S293
K
G
D
W
S
D
S
S
S
K
W
E
L
L
S
Site 25
S294
G
D
W
S
D
S
S
S
K
W
E
L
L
S
P
Site 26
S300
S
S
K
W
E
L
L
S
P
K
E
K
I
L
L
Site 27
S341
K
L
T
P
G
L
L
S
Q
E
A
A
Q
K
W
Site 28
Y350
E
A
A
Q
K
W
T
Y
T
M
R
E
G
R
W
Site 29
S361
E
G
R
W
E
K
R
S
T
A
G
G
Q
R
Q
Site 30
T362
G
R
W
E
K
R
S
T
A
G
G
Q
R
Q
L
Site 31
T373
Q
R
Q
L
L
Q
D
T
F
W
K
N
P
Q
F
Site 32
S383
K
N
P
Q
F
L
L
S
V
W
R
P
E
E
G
Site 33
S393
R
P
E
E
G
R
R
S
L
R
P
C
S
V
L
Site 34
S402
R
P
C
S
V
L
V
S
L
L
Q
K
P
R
H
Site 35
Y425
L
A
I
G
F
Y
L
Y
R
M
N
K
Y
H
D
Site 36
Y430
Y
L
Y
R
M
N
K
Y
H
D
D
Q
R
R
L
Site 37
T446
P
E
F
F
Q
R
N
T
P
L
S
Q
P
D
R
Site 38
S449
F
Q
R
N
T
P
L
S
Q
P
D
R
F
L
K
Site 39
S461
F
L
K
E
K
E
V
S
Q
E
L
C
L
E
P
Site 40
S492
E
F
V
L
R
V
F
S
R
K
H
I
F
Y
E
Site 41
Y498
F
S
R
K
H
I
F
Y
E
I
G
S
N
S
G
Site 42
S504
F
Y
E
I
G
S
N
S
G
V
V
F
S
K
E
Site 43
S509
S
N
S
G
V
V
F
S
K
E
I
E
D
Q
N
Site 44
T546
Q
N
L
L
N
Q
M
T
W
S
S
L
G
S
R
Site 45
S548
L
L
N
Q
M
T
W
S
S
L
G
S
R
Q
P
Site 46
S549
L
N
Q
M
T
W
S
S
L
G
S
R
Q
P
F
Site 47
S552
M
T
W
S
S
L
G
S
R
Q
P
F
F
S
L
Site 48
S558
G
S
R
Q
P
F
F
S
L
E
A
C
Q
G
I
Site 49
T576
L
D
L
N
A
S
G
T
M
S
I
Q
E
F
R
Site 50
S578
L
N
A
S
G
T
M
S
I
Q
E
F
R
D
L
Site 51
S592
L
W
K
Q
L
K
L
S
Q
K
V
F
H
K
Q
Site 52
Y605
K
Q
D
R
G
S
G
Y
L
N
W
E
Q
L
H
Site 53
T664
E
D
V
F
Q
N
L
T
Q
D
G
K
G
I
Y
Site 54
Y671
T
Q
D
G
K
G
I
Y
L
Q
K
P
E
W
M
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation