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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
DDX39
Full Name:
ATP-dependent RNA helicase DDX39
Alias:
ATP-dependent helicase DDX39; BAT1; BAT1L; DDXL; DEAD (Asp-Glu-Ala-Asp) box polypeptide 39; DEAD box protein 39; DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 39; DEAD-box protein 39; Nuclear RNA helicase URH49; Nuclear RNA helicase, DECD variant of DEAD box family; UAP56-related helicase, 49 kDa; URH49
Type:
EC 3.6.1.-; RNA binding protein; Helicase
Mass (Da):
49130
Number AA:
427
UniProt ID:
O00148
International Prot ID:
IPI00644431
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
GO:0043226
GO:0043227
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0008026
GO:0003676
PhosphoSite+
KinaseNET
Biological Process:
GO:0006406
GO:0000398
GO:0000398
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y13
V
E
N
D
L
L
D
Y
D
E
E
E
E
P
Q
Site 2
S25
E
P
Q
A
P
Q
E
S
T
P
A
P
P
K
K
Site 3
T26
P
Q
A
P
Q
E
S
T
P
A
P
P
K
K
D
Site 4
S37
P
K
K
D
I
K
G
S
Y
V
S
I
H
S
S
Site 5
Y38
K
K
D
I
K
G
S
Y
V
S
I
H
S
S
G
Site 6
S40
D
I
K
G
S
Y
V
S
I
H
S
S
G
F
R
Site 7
S129
R
E
L
A
F
Q
I
S
K
E
Y
E
R
F
S
Site 8
Y132
A
F
Q
I
S
K
E
Y
E
R
F
S
K
Y
M
Site 9
S136
S
K
E
Y
E
R
F
S
K
Y
M
P
S
V
K
Site 10
Y138
E
Y
E
R
F
S
K
Y
M
P
S
V
K
V
S
Site 11
T171
C
P
H
V
V
V
G
T
P
G
R
I
L
A
L
Site 12
S183
L
A
L
V
R
N
R
S
F
S
L
K
N
V
K
Site 13
S185
L
V
R
N
R
S
F
S
L
K
N
V
K
H
F
Site 14
T217
V
Q
E
I
F
R
L
T
P
H
E
K
Q
C
M
Site 15
S227
E
K
Q
C
M
M
F
S
A
T
L
S
K
D
I
Site 16
T229
Q
C
M
M
F
S
A
T
L
S
K
D
I
R
P
Site 17
T254
E
V
F
V
D
D
E
T
K
L
T
L
H
G
L
Site 18
T257
V
D
D
E
T
K
L
T
L
H
G
L
Q
Q
Y
Site 19
Y265
L
H
G
L
Q
Q
Y
Y
V
K
L
K
D
S
E
Site 20
S327
M
A
Q
E
E
R
L
S
R
Y
Q
Q
F
K
D
Site 21
Y361
R
V
N
I
V
F
N
Y
D
M
P
E
D
S
D
Site 22
T369
D
M
P
E
D
S
D
T
Y
L
H
R
V
A
R
Site 23
Y370
M
P
E
D
S
D
T
Y
L
H
R
V
A
R
A
Site 24
T388
G
T
K
G
L
A
I
T
F
V
S
D
E
N
D
Site 25
S420
L
P
E
E
I
D
I
S
T
Y
I
E
Q
S
R
Site 26
T421
P
E
E
I
D
I
S
T
Y
I
E
Q
S
R
_
Site 27
Y422
E
E
I
D
I
S
T
Y
I
E
Q
S
R
_
_
Site 28
S426
I
S
T
Y
I
E
Q
S
R
_
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation