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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ACOT7
Full Name:
Cytosolic acyl coenzyme A thioester hydrolase
Alias:
Long chain acyl-CoA thioester hydrolase
Type:
Mass (Da):
41778
Number AA:
380
UniProt ID:
O00154
International Prot ID:
IPI00010415
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005739
GO:0043226
Uniprot
OncoNet
Molecular Function:
GO:0000062
GO:0003824
GO:0004091
PhosphoSite+
KinaseNET
Biological Process:
GO:0006629
GO:0008152
GO:0044238
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S18
C
E
F
G
R
Q
A
S
S
R
R
L
V
A
G
Site 2
S19
E
F
G
R
Q
A
S
S
R
R
L
V
A
G
Q
Site 3
T56
P
P
C
G
A
C
I
T
G
R
I
M
R
P
D
Site 4
S88
E
E
A
G
A
I
I
S
T
R
H
C
N
S
Q
Site 5
T129
A
H
V
S
A
E
I
T
Y
T
S
K
H
S
V
Site 6
T131
V
S
A
E
I
T
Y
T
S
K
H
S
V
E
V
Site 7
T149
V
M
S
E
N
I
L
T
G
A
K
K
L
T
N
Site 8
T155
L
T
G
A
K
K
L
T
N
K
A
T
L
W
Y
Site 9
T159
K
K
L
T
N
K
A
T
L
W
Y
V
P
L
S
Site 10
Y162
T
N
K
A
T
L
W
Y
V
P
L
S
L
K
N
Site 11
Y181
L
E
V
P
P
V
V
Y
S
R
Q
E
Q
E
E
Site 12
Y194
E
E
E
G
R
K
R
Y
E
A
Q
K
L
E
R
Site 13
T204
Q
K
L
E
R
M
E
T
K
W
R
N
G
D
I
Site 14
T222
V
L
N
P
E
P
N
T
V
S
Y
S
Q
S
S
Site 15
S224
N
P
E
P
N
T
V
S
Y
S
Q
S
S
L
I
Site 16
Y225
P
E
P
N
T
V
S
Y
S
Q
S
S
L
I
H
Site 17
S226
E
P
N
T
V
S
Y
S
Q
S
S
L
I
H
L
Site 18
T268
V
A
A
R
H
C
K
T
N
I
V
T
A
S
V
Site 19
T297
I
T
I
S
G
R
M
T
F
T
S
N
K
S
M
Site 20
T299
I
S
G
R
M
T
F
T
S
N
K
S
M
E
I
Site 21
S300
S
G
R
M
T
F
T
S
N
K
S
M
E
I
E
Site 22
S303
M
T
F
T
S
N
K
S
M
E
I
E
V
L
V
Site 23
S318
D
A
D
P
V
V
D
S
S
Q
K
R
Y
R
A
Site 24
S319
A
D
P
V
V
D
S
S
Q
K
R
Y
R
A
A
Site 25
Y323
V
D
S
S
Q
K
R
Y
R
A
A
S
A
F
F
Site 26
S327
Q
K
R
Y
R
A
A
S
A
F
F
T
Y
V
S
Site 27
S334
S
A
F
F
T
Y
V
S
L
S
Q
E
G
R
S
Site 28
S336
F
F
T
Y
V
S
L
S
Q
E
G
R
S
L
P
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation