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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
MYO1C
Full Name:
Myosin-Ic
Alias:
MMIb; MMI-beta; MY1C; Myosin I beta; Myosin Ic; Myr2
Type:
Mass (Da):
121724
Number AA:
1063
UniProt ID:
O00159
International Prot ID:
IPI00010418
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0009925
GO:0005737
GO:0031941
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0003779
GO:0005516
PhosphoSite+
KinaseNET
Biological Process:
GO:0051028
GO:0015031
GO:0055085
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S38
G
V
R
V
T
M
E
S
A
L
T
A
R
D
R
Site 2
T41
V
T
M
E
S
A
L
T
A
R
D
R
V
G
V
Site 3
T78
F
R
E
N
L
I
Y
T
Y
I
G
P
V
L
V
Site 4
Y79
R
E
N
L
I
Y
T
Y
I
G
P
V
L
V
S
Site 5
Y96
P
Y
R
D
L
Q
I
Y
S
R
Q
H
M
E
R
Site 6
Y104
S
R
Q
H
M
E
R
Y
R
G
V
S
F
Y
E
Site 7
S108
M
E
R
Y
R
G
V
S
F
Y
E
V
P
P
H
Site 8
Y110
R
Y
R
G
V
S
F
Y
E
V
P
P
H
L
F
Site 9
Y124
F
A
V
A
D
T
V
Y
R
A
L
R
T
E
R
Site 10
T129
T
V
Y
R
A
L
R
T
E
R
R
D
Q
A
V
Site 11
T147
G
E
S
G
A
G
K
T
E
A
T
K
R
L
L
Site 12
T150
G
A
G
K
T
E
A
T
K
R
L
L
Q
F
Y
Site 13
Y157
T
K
R
L
L
Q
F
Y
A
E
T
C
P
A
P
Site 14
S177
V
R
D
R
L
L
Q
S
N
P
V
L
E
A
F
Site 15
T189
E
A
F
G
N
A
K
T
L
R
N
D
N
S
S
Site 16
S195
K
T
L
R
N
D
N
S
S
R
F
G
K
Y
M
Site 17
S196
T
L
R
N
D
N
S
S
R
F
G
K
Y
M
D
Site 18
Y201
N
S
S
R
F
G
K
Y
M
D
V
Q
F
D
F
Site 19
S219
P
V
G
G
H
I
L
S
Y
L
L
E
K
S
R
Site 20
S225
L
S
Y
L
L
E
K
S
R
V
V
H
Q
N
H
Site 21
Y241
E
R
N
F
H
I
F
Y
Q
L
L
E
G
G
E
Site 22
T251
L
E
G
G
E
E
E
T
L
R
R
L
G
L
E
Site 23
S263
G
L
E
R
N
P
Q
S
Y
L
Y
L
V
K
G
Site 24
Y264
L
E
R
N
P
Q
S
Y
L
Y
L
V
K
G
Q
Site 25
Y266
R
N
P
Q
S
Y
L
Y
L
V
K
G
Q
C
A
Site 26
S277
G
Q
C
A
K
V
S
S
I
N
D
K
S
D
W
Site 27
S282
V
S
S
I
N
D
K
S
D
W
K
V
V
R
K
Site 28
Y337
T
T
E
N
Q
L
K
Y
L
T
R
L
L
S
V
Site 29
S343
K
Y
L
T
R
L
L
S
V
E
G
S
T
L
R
Site 30
S347
R
L
L
S
V
E
G
S
T
L
R
E
A
L
T
Site 31
T348
L
L
S
V
E
G
S
T
L
R
E
A
L
T
H
Site 32
T354
S
T
L
R
E
A
L
T
H
R
K
I
I
A
K
Site 33
S367
A
K
G
E
E
L
L
S
P
L
N
L
E
Q
A
Site 34
Y376
L
N
L
E
Q
A
A
Y
A
R
D
A
L
A
K
Site 35
S400
L
V
G
K
I
N
R
S
L
A
S
K
D
V
E
Site 36
S403
K
I
N
R
S
L
A
S
K
D
V
E
S
P
S
Site 37
S408
L
A
S
K
D
V
E
S
P
S
W
R
S
T
T
Site 38
S410
S
K
D
V
E
S
P
S
W
R
S
T
T
V
L
Site 39
T414
E
S
P
S
W
R
S
T
T
V
L
G
L
L
D
Site 40
T453
Q
Q
L
F
I
E
L
T
L
K
S
E
Q
E
E
Site 41
S456
F
I
E
L
T
L
K
S
E
Q
E
E
Y
E
A
Site 42
Y461
L
K
S
E
Q
E
E
Y
E
A
E
G
I
A
W
Site 43
Y473
I
A
W
E
P
V
Q
Y
F
N
N
K
I
I
C
Site 44
T505
C
L
R
P
G
E
A
T
D
L
T
F
L
E
K
Site 45
T508
P
G
E
A
T
D
L
T
F
L
E
K
L
E
D
Site 46
T516
F
L
E
K
L
E
D
T
V
K
H
H
P
H
F
Site 47
T533
H
K
L
A
D
Q
R
T
R
K
S
L
G
R
G
Site 48
S536
A
D
Q
R
T
R
K
S
L
G
R
G
E
F
R
Site 49
S554
Y
A
G
E
V
T
Y
S
V
T
G
F
L
D
K
Site 50
T573
L
F
R
N
L
K
E
T
M
C
S
S
K
N
P
Site 51
S577
L
K
E
T
M
C
S
S
K
N
P
I
M
S
Q
Site 52
S583
S
S
K
N
P
I
M
S
Q
C
F
D
R
S
E
Site 53
S589
M
S
Q
C
F
D
R
S
E
L
S
D
K
K
R
Site 54
S592
C
F
D
R
S
E
L
S
D
K
K
R
P
E
T
Site 55
T599
S
D
K
K
R
P
E
T
V
A
T
Q
F
K
M
Site 56
T602
K
R
P
E
T
V
A
T
Q
F
K
M
S
L
L
Site 57
S617
Q
L
V
E
I
L
Q
S
K
E
P
A
Y
V
R
Site 58
Y622
L
Q
S
K
E
P
A
Y
V
R
C
I
K
P
N
Site 59
Y664
V
R
R
A
G
F
A
Y
R
R
K
Y
E
A
F
Site 60
Y668
G
F
A
Y
R
R
K
Y
E
A
F
L
Q
R
Y
Site 61
S677
A
F
L
Q
R
Y
K
S
L
C
P
E
T
W
P
Site 62
Y708
L
G
Y
K
P
E
E
Y
K
M
G
R
T
K
I
Site 63
S736
A
L
E
V
R
R
Q
S
L
A
T
K
I
Q
A
Site 64
T771
I
Q
S
W
W
R
G
T
L
G
R
R
K
A
A
Site 65
T786
K
R
K
W
A
A
Q
T
I
R
R
L
I
R
G
Site 66
S815
F
L
D
H
V
R
T
S
F
L
L
N
L
R
R
Site 67
T831
L
P
R
N
V
L
D
T
S
W
P
T
P
P
P
Site 68
S832
P
R
N
V
L
D
T
S
W
P
T
P
P
P
A
Site 69
T835
V
L
D
T
S
W
P
T
P
P
P
A
L
R
E
Site 70
S844
P
P
A
L
R
E
A
S
E
L
L
R
E
L
C
Site 71
Y859
I
K
N
M
V
W
K
Y
C
R
S
I
S
P
E
Site 72
Y888
F
K
G
K
K
D
N
Y
P
Q
S
V
P
R
L
Site 73
S891
K
K
D
N
Y
P
Q
S
V
P
R
L
F
I
S
Site 74
S898
S
V
P
R
L
F
I
S
T
R
L
G
T
D
E
Site 75
T903
F
I
S
T
R
L
G
T
D
E
I
S
P
R
V
Site 76
S907
R
L
G
T
D
E
I
S
P
R
V
L
Q
A
L
Site 77
Y928
Y
A
V
P
V
V
K
Y
D
R
K
G
Y
K
P
Site 78
Y933
V
K
Y
D
R
K
G
Y
K
P
R
S
R
Q
L
Site 79
S937
R
K
G
Y
K
P
R
S
R
Q
L
L
L
T
P
Site 80
Y961
K
V
K
Q
R
I
D
Y
A
N
L
T
G
I
S
Site 81
S1009
T
L
T
K
T
A
L
S
A
N
R
V
N
S
I
Site 82
S1015
L
S
A
N
R
V
N
S
I
N
I
N
Q
G
S
Site 83
T1024
N
I
N
Q
G
S
I
T
F
A
G
G
P
G
R
Site 84
T1034
G
G
P
G
R
D
G
T
I
D
F
T
P
G
S
Site 85
T1038
R
D
G
T
I
D
F
T
P
G
S
E
L
L
I
Site 86
T1046
P
G
S
E
L
L
I
T
K
A
K
N
G
H
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation