PhosphoNET

           
Protein Info 
   
Short Name:  EYA2
Full Name:  Eyes absent homolog 2
Alias:  EAB1; Eyes absent 2; MGC10614
Type:  Protein phosphatase, tyrosine (non-receptor); Apoptosis; Cell development/differentiation; EC 3.1.3.48
Mass (Da):  59214
Number AA:  538
UniProt ID:  O00167
International Prot ID:  IPI00216797
Sequence:  Retrieve full protein sequence
   
GO Terms  External Links Internal Links  
   
Cellular Component:  GO:0005737  GO:0005634   Uniprot OncoNet
Molecular Function:  GO:0000287  GO:0004725   PhosphoSite+ KinaseNET
Biological Process:  GO:0006281  GO:0016576  GO:0007501 Phosida TranscriptoNet
    STRING Kinexus Products
   
Info Box  A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites 
-7-6-5-4-3-2-101234567Expt. conf.EffectKinasePPaseKinexus ProductsRef.Evol.Kinase Pred.P-site Match
Site 1T31RADAAVWTLSDRQGI
Site 2S33DAAVWTLSDRQGITK
Site 3S41DRQGITKSAPLRVSQ
Site 4S47KSAPLRVSQLFSRSC
Site 5S53VSQLFSRSCPRVLPR
Site 6S63RVLPRQPSTAMAAYG
Site 7S75AYGQTQYSAGIQQAT
Site 8T82SAGIQQATPYTAYPP
Site 9Y84GIQQATPYTAYPPPA
Site 10T85IQQATPYTAYPPPAQ
Site 11Y87QATPYTAYPPPAQAY
Site 12Y94YPPPAQAYGIPSYSI
Site 13S106YSIKTEDSLNHSPGQ
Site 14S110TEDSLNHSPGQSGFL
Site 15S114LNHSPGQSGFLSYGS
Site 16S118PGQSGFLSYGSSFST
Site 17Y119GQSGFLSYGSSFSTS
Site 18S121SGFLSYGSSFSTSPT
Site 19S122GFLSYGSSFSTSPTG
Site 20S124LSYGSSFSTSPTGQS
Site 21T125SYGSSFSTSPTGQSP
Site 22S126YGSSFSTSPTGQSPY
Site 23T128SSFSTSPTGQSPYTY
Site 24S131STSPTGQSPYTYQMH
Site 25Y133SPTGQSPYTYQMHGT
Site 26T134PTGQSPYTYQMHGTT
Site 27Y135TGQSPYTYQMHGTTG
Site 28Y144MHGTTGFYQGGNGLG
Site 29S158GNAAGFGSVHQDYPS
Site 30Y163FGSVHQDYPSYPGFP
Site 31S165SVHQDYPSYPGFPQS
Site 32Y166VHQDYPSYPGFPQSQ
Site 33Y174PGFPQSQYPQYYGSS
Site 34Y177PQSQYPQYYGSSYNP
Site 35Y178QSQYPQYYGSSYNPP
Site 36Y182PQYYGSSYNPPYVPA
Site 37Y186GSSYNPPYVPASSIC
Site 38S190NPPYVPASSICPSPL
Site 39S195PASSICPSPLSTSTY
Site 40Y202SPLSTSTYVLQEASH
Site 41S218VPNQSSESLAGEYNT
Site 42Y223SESLAGEYNTHNGPS
Site 43T231NTHNGPSTPAKEGDT
Site 44T238TPAKEGDTDRPHRAS
Site 45S245TDRPHRASDGKLRGR
Site 46S253DGKLRGRSKRSSDPS
Site 47S256LRGRSKRSSDPSPAG
Site 48S257RGRSKRSSDPSPAGD
Site 49S260SKRSSDPSPAGDNEI
Site 50T289FHSLLTGTFASRYGK
Site 51Y294TGTFASRYGKDTTTS
Site 52T298ASRYGKDTTTSVRIG
Site 53T299SRYGKDTTTSVRIGL
Site 54T300RYGKDTTTSVRIGLM
Site 55S301YGKDTTTSVRIGLMM
Site 56S337QIHVDDVSSDDNGQD
Site 57S338IHVDDVSSDDNGQDL
Site 58S346DDNGQDLSTYNFSAD
Site 59T347DNGQDLSTYNFSADG
Site 60Y348NGQDLSTYNFSADGF
Site 61S351DLSTYNFSADGFHSS
Site 62S358SADGFHSSAPGANLC
Site 63Y384MRKLAFRYRRVKEMY
Site 64Y391YRRVKEMYNTYKNNV
Site 65Y394VKEMYNTYKNNVGGL
Site 66T404NVGGLIGTPKRETWL
Site 67T409IGTPKRETWLQLRAE
Site 68S437KALNLINSRPNCVNV
Site 69Y473VFPIENIYSATKTGK
Site 70S474FPIENIYSATKTGKE
Site 71T478NIYSATKTGKESCFE
 
Legend 
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available  
Products available
 


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