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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
STXBP3
Full Name:
Syntaxin-binding protein 3
Alias:
MUNC18-3; MUNC18C; Platelet Sec1; Platelet Sec1 protein; PSP; STXB3; Syntaxin 4 binding protein; Syntaxin binding protein 3; UNC-18 homolog 3; Unc-18 homolog 3; UNC-18-3; UNC-18C; Unc-18C
Type:
Vesicle protein
Mass (Da):
67764
Number AA:
592
UniProt ID:
O00186
International Prot ID:
IPI00297626
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
GO:0031091
GO:0042581
Uniprot
OncoNet
Molecular Function:
GO:0030347
PhosphoSite+
KinaseNET
Biological Process:
GO:0045955
GO:0043312
GO:0070527
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S12
V
A
E
R
G
L
K
S
V
V
W
Q
K
I
K
Site 2
Y66
I
T
V
V
E
N
I
Y
K
N
R
E
P
V
R
Site 3
Y79
V
R
Q
M
K
A
L
Y
F
I
T
P
T
S
K
Site 4
T82
M
K
A
L
Y
F
I
T
P
T
S
K
S
V
D
Site 5
S87
F
I
T
P
T
S
K
S
V
D
C
F
L
H
D
Site 6
S99
L
H
D
F
A
S
K
S
E
N
K
Y
K
A
A
Site 7
Y103
A
S
K
S
E
N
K
Y
K
A
A
Y
I
Y
F
Site 8
Y109
K
Y
K
A
A
Y
I
Y
F
T
D
F
C
P
D
Site 9
T111
K
A
A
Y
I
Y
F
T
D
F
C
P
D
N
L
Site 10
S125
L
F
N
K
I
K
A
S
C
S
K
S
I
R
R
Site 11
S127
N
K
I
K
A
S
C
S
K
S
I
R
R
C
K
Site 12
S129
I
K
A
S
C
S
K
S
I
R
R
C
K
E
I
Site 13
S139
R
C
K
E
I
N
I
S
F
I
P
H
E
S
Q
Site 14
S145
I
S
F
I
P
H
E
S
Q
V
Y
T
L
D
V
Site 15
Y148
I
P
H
E
S
Q
V
Y
T
L
D
V
P
D
A
Site 16
T149
P
H
E
S
Q
V
Y
T
L
D
V
P
D
A
F
Site 17
Y157
L
D
V
P
D
A
F
Y
Y
C
Y
S
P
D
P
Site 18
Y158
D
V
P
D
A
F
Y
Y
C
Y
S
P
D
P
G
Site 19
Y160
P
D
A
F
Y
Y
C
Y
S
P
D
P
G
N
A
Site 20
S198
N
P
G
V
R
Y
K
S
K
P
L
D
N
A
S
Site 21
Y218
V
E
K
K
L
E
D
Y
Y
K
I
D
E
K
S
Site 22
Y219
E
K
K
L
E
D
Y
Y
K
I
D
E
K
S
L
Site 23
S225
Y
Y
K
I
D
E
K
S
L
I
K
G
K
T
H
Site 24
S233
L
I
K
G
K
T
H
S
Q
L
L
I
I
D
R
Site 25
S246
D
R
G
F
D
P
V
S
T
V
L
H
E
L
T
Site 26
Y269
L
P
I
E
N
D
T
Y
K
Y
K
T
D
G
K
Site 27
Y271
I
E
N
D
T
Y
K
Y
K
T
D
G
K
E
K
Site 28
S312
P
K
L
M
K
E
I
S
S
T
K
K
A
T
E
Site 29
S313
K
L
M
K
E
I
S
S
T
K
K
A
T
E
G
Site 30
T314
L
M
K
E
I
S
S
T
K
K
A
T
E
G
K
Site 31
S323
K
A
T
E
G
K
T
S
L
S
A
L
T
Q
L
Site 32
S386
E
G
Q
K
V
K
D
S
M
R
V
L
L
P
V
Site 33
T418
Y
I
F
S
I
N
G
T
T
E
E
N
L
D
R
Site 34
S453
G
V
P
I
V
P
Q
S
Q
Q
G
K
P
L
R
Site 35
S464
K
P
L
R
K
D
R
S
A
E
E
T
F
Q
L
Site 36
T468
K
D
R
S
A
E
E
T
F
Q
L
S
R
W
T
Site 37
S472
A
E
E
T
F
Q
L
S
R
W
T
P
F
I
K
Site 38
S492
A
I
D
N
R
L
D
S
K
E
W
P
Y
C
S
Site 39
Y497
L
D
S
K
E
W
P
Y
C
S
Q
C
P
A
V
Site 40
S512
W
N
G
S
G
A
V
S
A
R
Q
K
P
R
A
Site 41
Y521
R
Q
K
P
R
A
N
Y
L
E
D
R
K
N
G
Site 42
S542
V
I
G
G
I
T
Y
S
E
V
R
C
A
Y
E
Site 43
Y548
Y
S
E
V
R
C
A
Y
E
V
S
Q
A
H
K
Site 44
S556
E
V
S
Q
A
H
K
S
C
E
V
I
I
G
S
Site 45
T568
I
G
S
T
H
V
L
T
P
K
K
L
L
D
D
Site 46
S587
N
K
P
K
D
K
V
S
L
I
K
D
E
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation