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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
MASP2
Full Name:
Mannan-binding lectin serine protease 2
Alias:
EC 3.4.21.104; Mannose-binding protein-associated serine protease 2; MASP-2; MBL-associated serine protease 2
Type:
Protease protein
Mass (Da):
75733
Number AA:
686
UniProt ID:
O00187
International Prot ID:
IPI00294713
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005576
Uniprot
OncoNet
Molecular Function:
GO:0005509
GO:0048306
GO:0004252
PhosphoSite+
KinaseNET
Biological Process:
GO:0006958
GO:0001867
GO:0006508
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S32
P
V
F
G
R
L
A
S
P
G
F
P
G
E
Y
Site 2
Y39
S
P
G
F
P
G
E
Y
A
N
D
Q
E
R
R
Site 3
T48
N
D
Q
E
R
R
W
T
L
T
A
P
P
G
Y
Site 4
T50
Q
E
R
R
W
T
L
T
A
P
P
G
Y
R
L
Site 5
Y60
P
G
Y
R
L
R
L
Y
F
T
H
F
D
L
E
Site 6
Y74
E
L
S
H
L
C
E
Y
D
F
V
K
L
S
S
Site 7
T97
C
G
Q
E
S
T
D
T
E
R
A
P
G
K
D
Site 8
T105
E
R
A
P
G
K
D
T
F
Y
S
L
G
S
S
Site 9
Y107
A
P
G
K
D
T
F
Y
S
L
G
S
S
L
D
Site 10
S108
P
G
K
D
T
F
Y
S
L
G
S
S
L
D
I
Site 11
S112
T
F
Y
S
L
G
S
S
L
D
I
T
F
R
S
Site 12
T116
L
G
S
S
L
D
I
T
F
R
S
D
Y
S
N
Site 13
S119
S
L
D
I
T
F
R
S
D
Y
S
N
E
K
P
Site 14
Y121
D
I
T
F
R
S
D
Y
S
N
E
K
P
F
T
Site 15
T128
Y
S
N
E
K
P
F
T
G
F
E
A
F
Y
A
Site 16
Y164
H
N
H
L
G
G
F
Y
C
S
C
R
A
G
Y
Site 17
Y171
Y
C
S
C
R
A
G
Y
V
L
H
R
N
K
R
Site 18
S181
H
R
N
K
R
T
C
S
A
L
C
S
G
Q
V
Site 19
S185
R
T
C
S
A
L
C
S
G
Q
V
F
T
Q
R
Site 20
T190
L
C
S
G
Q
V
F
T
Q
R
S
G
E
L
S
Site 21
S193
G
Q
V
F
T
Q
R
S
G
E
L
S
S
P
E
Site 22
S197
T
Q
R
S
G
E
L
S
S
P
E
Y
P
R
P
Site 23
S198
Q
R
S
G
E
L
S
S
P
E
Y
P
R
P
Y
Site 24
Y201
G
E
L
S
S
P
E
Y
P
R
P
Y
P
K
L
Site 25
Y205
S
P
E
Y
P
R
P
Y
P
K
L
S
S
C
T
Site 26
S209
P
R
P
Y
P
K
L
S
S
C
T
Y
S
I
S
Site 27
S210
R
P
Y
P
K
L
S
S
C
T
Y
S
I
S
L
Site 28
T212
Y
P
K
L
S
S
C
T
Y
S
I
S
L
E
E
Site 29
Y213
P
K
L
S
S
C
T
Y
S
I
S
L
E
E
G
Site 30
S214
K
L
S
S
C
T
Y
S
I
S
L
E
E
G
F
Site 31
S216
S
S
C
T
Y
S
I
S
L
E
E
G
F
S
V
Site 32
T235
V
E
S
F
D
V
E
T
H
P
E
T
L
C
P
Site 33
T239
D
V
E
T
H
P
E
T
L
C
P
Y
D
F
L
Site 34
T250
Y
D
F
L
K
I
Q
T
D
R
E
E
H
G
P
Site 35
T262
H
G
P
F
C
G
K
T
L
P
H
R
I
E
T
Site 36
T269
T
L
P
H
R
I
E
T
K
S
N
T
V
T
I
Site 37
S271
P
H
R
I
E
T
K
S
N
T
V
T
I
T
F
Site 38
T275
E
T
K
S
N
T
V
T
I
T
F
V
T
D
E
Site 39
T277
K
S
N
T
V
T
I
T
F
V
T
D
E
S
G
Site 40
T287
T
D
E
S
G
D
H
T
G
W
K
I
H
Y
T
Site 41
Y302
S
T
A
H
A
C
P
Y
P
M
A
P
P
N
G
Site 42
S312
A
P
P
N
G
H
V
S
P
V
Q
A
K
Y
I
Site 43
Y318
V
S
P
V
Q
A
K
Y
I
L
K
D
S
F
S
Site 44
S343
Q
G
H
L
P
L
K
S
F
T
A
V
C
Q
K
Site 45
S362
D
R
P
M
P
A
C
S
I
V
D
C
G
P
P
Site 46
Y371
V
D
C
G
P
P
D
Y
L
P
S
G
R
V
E
Site 47
S374
G
P
P
D
Y
L
P
S
G
R
V
E
Y
I
T
Site 48
Y379
L
P
S
G
R
V
E
Y
I
T
G
P
G
V
T
Site 49
T381
S
G
R
V
E
Y
I
T
G
P
G
V
T
T
Y
Site 50
Y388
T
G
P
G
V
T
T
Y
K
A
V
I
Q
Y
S
Site 51
Y394
T
Y
K
A
V
I
Q
Y
S
C
E
E
T
F
Y
Site 52
Y401
Y
S
C
E
E
T
F
Y
T
M
K
V
N
D
G
Site 53
Y410
M
K
V
N
D
G
K
Y
V
C
E
A
D
G
F
Site 54
S420
E
A
D
G
F
W
T
S
S
K
G
E
K
S
L
Site 55
S421
A
D
G
F
W
T
S
S
K
G
E
K
S
L
P
Site 56
S426
T
S
S
K
G
E
K
S
L
P
V
C
E
P
V
Site 57
S437
C
E
P
V
C
G
L
S
A
R
T
T
G
G
R
Site 58
T441
C
G
L
S
A
R
T
T
G
G
R
I
Y
G
G
Site 59
Y446
R
T
T
G
G
R
I
Y
G
G
Q
K
A
K
P
Site 60
T501
A
L
D
I
R
M
G
T
L
K
R
L
S
P
H
Site 61
S506
M
G
T
L
K
R
L
S
P
H
Y
T
Q
A
W
Site 62
Y509
L
K
R
L
S
P
H
Y
T
Q
A
W
S
E
A
Site 63
T510
K
R
L
S
P
H
Y
T
Q
A
W
S
E
A
V
Site 64
Y523
A
V
F
I
H
E
G
Y
T
H
D
A
G
F
D
Site 65
T549
V
V
I
N
S
N
I
T
P
I
C
L
P
R
K
Site 66
S560
L
P
R
K
E
A
E
S
F
M
R
T
D
D
I
Site 67
T564
E
A
E
S
F
M
R
T
D
D
I
G
T
A
S
Site 68
T569
M
R
T
D
D
I
G
T
A
S
G
W
G
L
T
Site 69
S571
T
D
D
I
G
T
A
S
G
W
G
L
T
Q
R
Site 70
T576
T
A
S
G
W
G
L
T
Q
R
G
F
L
A
R
Site 71
T599
I
V
D
H
Q
K
C
T
A
A
Y
E
K
P
P
Site 72
Y602
H
Q
K
C
T
A
A
Y
E
K
P
P
Y
P
R
Site 73
Y607
A
A
Y
E
K
P
P
Y
P
R
G
S
V
T
A
Site 74
S611
K
P
P
Y
P
R
G
S
V
T
A
N
M
L
C
Site 75
S628
L
E
S
G
G
K
D
S
C
R
G
D
S
G
G
Site 76
S633
K
D
S
C
R
G
D
S
G
G
A
L
V
F
L
Site 77
Y666
N
C
G
E
A
G
Q
Y
G
V
Y
T
K
V
I
Site 78
Y669
E
A
G
Q
Y
G
V
Y
T
K
V
I
N
Y
I
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation