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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
AP3B1
Full Name:
AP-3 complex subunit beta-1
Alias:
Adapter-related protein complex 3 beta-1 subunit; Adapter-related protein complex 3 subunit beta-1; Adaptor protein complex AP-3 beta-1 subunit; Adaptor-related protein complex 3, beta 1 subunit; ADTB3A; Beta3A-adaptin; Clathrin assembly protein complex 3 beta-1 large chain; HPS2
Type:
Vesicle protein
Mass (Da):
121320
Number AA:
1094
UniProt ID:
O00203
International Prot ID:
IPI00021129
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005794
GO:0031410
GO:0030117
Uniprot
OncoNet
Molecular Function:
GO:0019903
GO:0008565
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0006897
GO:0002475
GO:0002682
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y8
M
S
S
N
S
F
P
Y
N
E
Q
S
G
G
G
Site 2
T25
T
E
L
G
Q
E
A
T
S
T
I
S
P
S
G
Site 3
T27
L
G
Q
E
A
T
S
T
I
S
P
S
G
A
F
Site 4
S29
Q
E
A
T
S
T
I
S
P
S
G
A
F
G
L
Site 5
S38
S
G
A
F
G
L
F
S
S
D
L
K
K
N
E
Site 6
S39
G
A
F
G
L
F
S
S
D
L
K
K
N
E
D
Site 7
S53
D
L
K
Q
M
L
E
S
N
K
D
S
A
K
L
Site 8
S57
M
L
E
S
N
K
D
S
A
K
L
D
A
M
K
Site 9
S89
A
V
V
K
N
V
A
S
K
N
I
E
I
K
K
Site 10
S116
Q
Q
D
L
A
L
L
S
I
S
T
F
Q
R
A
Site 11
S140
A
S
A
L
R
V
L
S
S
I
R
V
P
I
I
Site 12
S141
S
A
L
R
V
L
S
S
I
R
V
P
I
I
V
Site 13
S163
K
E
A
S
A
D
L
S
P
Y
V
R
K
N
A
Site 14
Y165
A
S
A
D
L
S
P
Y
V
R
K
N
A
A
H
Site 15
S179
H
A
I
Q
K
L
Y
S
L
D
P
E
Q
K
E
Site 16
S200
E
K
L
L
K
D
K
S
T
L
V
A
G
S
V
Site 17
T254
M
L
T
R
Y
A
R
T
Q
F
V
S
P
W
K
Site 18
S258
Y
A
R
T
Q
F
V
S
P
W
K
E
G
D
E
Site 19
Y274
E
D
N
G
K
N
F
Y
E
S
D
D
D
Q
K
Site 20
S276
N
G
K
N
F
Y
E
S
D
D
D
Q
K
E
K
Site 21
T284
D
D
D
Q
K
E
K
T
D
K
K
K
K
P
Y
Site 22
T292
D
K
K
K
K
P
Y
T
M
D
P
D
H
R
L
Site 23
T304
H
R
L
L
I
R
N
T
K
P
L
L
Q
S
R
Site 24
S327
A
Q
L
Y
W
H
I
S
P
K
S
E
A
G
I
Site 25
S330
Y
W
H
I
S
P
K
S
E
A
G
I
I
S
K
Site 26
S345
S
L
V
R
L
L
R
S
N
R
E
V
Q
Y
I
Site 27
Y371
R
K
G
M
F
E
P
Y
L
K
S
F
Y
V
R
Site 28
S374
M
F
E
P
Y
L
K
S
F
Y
V
R
S
T
D
Site 29
Y376
E
P
Y
L
K
S
F
Y
V
R
S
T
D
P
T
Site 30
T380
K
S
F
Y
V
R
S
T
D
P
T
M
I
K
T
Site 31
T383
Y
V
R
S
T
D
P
T
M
I
K
T
L
K
L
Site 32
S403
L
A
N
E
A
N
I
S
T
L
L
R
E
F
Q
Site 33
T411
T
L
L
R
E
F
Q
T
Y
V
K
S
Q
D
K
Site 34
Y412
L
L
R
E
F
Q
T
Y
V
K
S
Q
D
K
Q
Site 35
S415
E
F
Q
T
Y
V
K
S
Q
D
K
Q
F
A
A
Site 36
T433
Q
T
I
G
R
C
A
T
N
I
L
E
V
T
D
Site 37
S524
V
L
R
K
M
A
K
S
F
T
S
E
D
D
L
Site 38
Y544
L
N
L
G
A
K
L
Y
L
T
N
S
K
Q
T
Site 39
T546
L
G
A
K
L
Y
L
T
N
S
K
Q
T
K
L
Site 40
S548
A
K
L
Y
L
T
N
S
K
Q
T
K
L
L
T
Site 41
T555
S
K
Q
T
K
L
L
T
Q
Y
I
L
N
L
G
Site 42
Y557
Q
T
K
L
L
T
Q
Y
I
L
N
L
G
K
Y
Site 43
Y564
Y
I
L
N
L
G
K
Y
D
Q
N
Y
D
I
R
Site 44
Y568
L
G
K
Y
D
Q
N
Y
D
I
R
D
R
T
R
Site 45
T574
N
Y
D
I
R
D
R
T
R
F
I
R
Q
L
I
Site 46
S591
N
V
K
S
G
A
L
S
K
Y
A
K
K
I
F
Site 47
Y593
K
S
G
A
L
S
K
Y
A
K
K
I
F
L
A
Site 48
S609
K
P
A
P
L
L
E
S
P
F
K
D
R
D
H
Site 49
T621
R
D
H
F
Q
L
G
T
L
S
H
T
L
N
I
Site 50
S623
H
F
Q
L
G
T
L
S
H
T
L
N
I
K
A
Site 51
Y633
L
N
I
K
A
T
G
Y
L
E
L
S
N
W
P
Site 52
S637
A
T
G
Y
L
E
L
S
N
W
P
E
V
A
P
Site 53
S647
P
E
V
A
P
D
P
S
V
R
N
V
E
V
I
Site 54
T661
I
E
L
A
K
E
W
T
P
A
G
K
A
K
Q
Site 55
S671
G
K
A
K
Q
E
N
S
A
K
K
F
Y
S
E
Site 56
S677
N
S
A
K
K
F
Y
S
E
S
E
E
E
E
D
Site 57
S679
A
K
K
F
Y
S
E
S
E
E
E
E
D
S
S
Site 58
S685
E
S
E
E
E
E
D
S
S
D
S
S
S
D
S
Site 59
S686
S
E
E
E
E
D
S
S
D
S
S
S
D
S
E
Site 60
S688
E
E
E
D
S
S
D
S
S
S
D
S
E
S
E
Site 61
S689
E
E
D
S
S
D
S
S
S
D
S
E
S
E
S
Site 62
S690
E
D
S
S
D
S
S
S
D
S
E
S
E
S
G
Site 63
S692
S
S
D
S
S
S
D
S
E
S
E
S
G
S
E
Site 64
S694
D
S
S
S
D
S
E
S
E
S
G
S
E
S
G
Site 65
S696
S
S
D
S
E
S
E
S
G
S
E
S
G
E
Q
Site 66
S698
D
S
E
S
E
S
G
S
E
S
G
E
Q
G
E
Site 67
S700
E
S
E
S
G
S
E
S
G
E
Q
G
E
S
G
Site 68
S706
E
S
G
E
Q
G
E
S
G
E
E
G
D
S
N
Site 69
S712
E
S
G
E
E
G
D
S
N
E
D
S
S
E
D
Site 70
S716
E
G
D
S
N
E
D
S
S
E
D
S
S
S
E
Site 71
S717
G
D
S
N
E
D
S
S
E
D
S
S
S
E
Q
Site 72
S720
N
E
D
S
S
E
D
S
S
S
E
Q
D
S
E
Site 73
S721
E
D
S
S
E
D
S
S
S
E
Q
D
S
E
S
Site 74
S722
D
S
S
E
D
S
S
S
E
Q
D
S
E
S
G
Site 75
S726
D
S
S
S
E
Q
D
S
E
S
G
R
E
S
G
Site 76
S728
S
S
E
Q
D
S
E
S
G
R
E
S
G
L
E
Site 77
S732
D
S
E
S
G
R
E
S
G
L
E
N
K
R
T
Site 78
T739
S
G
L
E
N
K
R
T
A
K
R
N
S
K
A
Site 79
S744
K
R
T
A
K
R
N
S
K
A
K
G
K
S
D
Site 80
S750
N
S
K
A
K
G
K
S
D
S
E
D
G
E
K
Site 81
S752
K
A
K
G
K
S
D
S
E
D
G
E
K
E
N
Site 82
S762
G
E
K
E
N
E
K
S
K
T
S
D
S
S
N
Site 83
T764
K
E
N
E
K
S
K
T
S
D
S
S
N
D
E
Site 84
S765
E
N
E
K
S
K
T
S
D
S
S
N
D
E
S
Site 85
S767
E
K
S
K
T
S
D
S
S
N
D
E
S
S
S
Site 86
S768
K
S
K
T
S
D
S
S
N
D
E
S
S
S
I
Site 87
S772
S
D
S
S
N
D
E
S
S
S
I
E
D
S
S
Site 88
S773
D
S
S
N
D
E
S
S
S
I
E
D
S
S
S
Site 89
S774
S
S
N
D
E
S
S
S
I
E
D
S
S
S
D
Site 90
S778
E
S
S
S
I
E
D
S
S
S
D
S
E
S
E
Site 91
S779
S
S
S
I
E
D
S
S
S
D
S
E
S
E
S
Site 92
S780
S
S
I
E
D
S
S
S
D
S
E
S
E
S
E
Site 93
S782
I
E
D
S
S
S
D
S
E
S
E
S
E
P
E
Site 94
S784
D
S
S
S
D
S
E
S
E
S
E
P
E
S
E
Site 95
S786
S
S
D
S
E
S
E
S
E
P
E
S
E
S
E
Site 96
S790
E
S
E
S
E
P
E
S
E
S
E
S
R
R
V
Site 97
S792
E
S
E
P
E
S
E
S
E
S
R
R
V
T
K
Site 98
S794
E
P
E
S
E
S
E
S
R
R
V
T
K
E
K
Site 99
T798
E
S
E
S
R
R
V
T
K
E
K
E
K
K
T
Site 100
T810
K
K
T
K
Q
D
R
T
P
L
T
K
D
V
S
Site 101
T813
K
Q
D
R
T
P
L
T
K
D
V
S
L
L
D
Site 102
S817
T
P
L
T
K
D
V
S
L
L
D
L
D
D
F
Site 103
T829
D
D
F
N
P
V
S
T
P
V
A
L
P
T
P
Site 104
Y886
G
K
G
L
A
A
H
Y
F
F
P
R
Q
P
C
Site 105
T905
K
M
V
S
I
Q
I
T
L
N
N
T
T
D
R
Site 106
S938
H
V
F
N
P
I
D
S
L
E
P
E
G
S
I
Site 107
S944
D
S
L
E
P
E
G
S
I
T
V
S
M
G
I
Site 108
T957
G
I
D
F
C
D
S
T
Q
T
A
S
F
Q
L
Site 109
S961
C
D
S
T
Q
T
A
S
F
Q
L
C
T
K
D
Site 110
S989
L
L
L
P
V
A
M
S
E
K
D
F
K
K
E
Site 111
S1037
A
N
V
G
A
V
P
S
G
Q
D
N
I
H
R
Site 112
T1077
L
I
I
N
T
E
K
T
V
I
G
S
V
L
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation