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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
Fe65
Full Name:
Amyloid beta A4 precursor protein-binding family B member 1
Alias:
ABB1; Amyloid beta (A4) precursor protein-binding, family B, member 1; Protein Fe65; RIR
Type:
Adaptor/scaffold; Apoptosis; Transcription regulation
Mass (Da):
77244
Number AA:
710
UniProt ID:
O00213
International Prot ID:
IPI00383108
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0030426
GO:0030027
Uniprot
OncoNet
Molecular Function:
GO:0001540
GO:0042393
GO:0070064
PhosphoSite+
KinaseNET
Biological Process:
GO:0006915
GO:0007409
GO:0007050
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S6
_
_
M
S
V
P
S
S
L
S
Q
S
A
I
N
Site 2
S8
M
S
V
P
S
S
L
S
Q
S
A
I
N
A
N
Site 3
S10
V
P
S
S
L
S
Q
S
A
I
N
A
N
S
H
Site 4
S16
Q
S
A
I
N
A
N
S
H
G
G
P
A
L
S
Site 5
S52
V
G
P
K
D
L
R
S
A
M
G
E
G
G
G
Site 6
T82
N
Q
L
R
R
A
A
T
A
H
R
D
Q
N
R
Site 7
T92
R
D
Q
N
R
N
V
T
L
T
L
A
E
E
A
Site 8
T94
Q
N
R
N
V
T
L
T
L
A
E
E
A
S
Q
Site 9
S100
L
T
L
A
E
E
A
S
Q
E
P
E
M
A
P
Site 10
S118
K
G
L
I
H
L
Y
S
E
L
E
L
S
A
H
Site 11
S123
L
Y
S
E
L
E
L
S
A
H
N
A
A
N
R
Site 12
S140
R
G
P
G
L
I
I
S
T
Q
E
Q
G
P
D
Site 13
S174
E
E
E
E
E
D
L
S
S
P
P
G
L
P
E
Site 14
S175
E
E
E
E
D
L
S
S
P
P
G
L
P
E
P
Site 15
S185
G
L
P
E
P
L
E
S
V
E
A
P
P
R
P
Site 16
T196
P
P
R
P
Q
A
L
T
D
G
P
R
E
H
S
Site 17
S203
T
D
G
P
R
E
H
S
K
S
A
S
L
L
F
Site 18
S205
G
P
R
E
H
S
K
S
A
S
L
L
F
G
M
Site 19
S207
R
E
H
S
K
S
A
S
L
L
F
G
M
R
N
Site 20
S215
L
L
F
G
M
R
N
S
A
A
S
D
E
D
S
Site 21
S218
G
M
R
N
S
A
A
S
D
E
D
S
S
W
A
Site 22
S222
S
A
A
S
D
E
D
S
S
W
A
T
L
S
Q
Site 23
S223
A
A
S
D
E
D
S
S
W
A
T
L
S
Q
G
Site 24
T226
D
E
D
S
S
W
A
T
L
S
Q
G
S
P
S
Site 25
S228
D
S
S
W
A
T
L
S
Q
G
S
P
S
Y
G
Site 26
S231
W
A
T
L
S
Q
G
S
P
S
Y
G
S
P
E
Site 27
Y234
L
S
Q
G
S
P
S
Y
G
S
P
E
D
T
D
Site 28
S236
Q
G
S
P
S
Y
G
S
P
E
D
T
D
S
F
Site 29
T240
S
Y
G
S
P
E
D
T
D
S
F
W
N
P
N
Site 30
S242
G
S
P
E
D
T
D
S
F
W
N
P
N
A
F
Site 31
S253
P
N
A
F
E
T
D
S
D
L
P
A
G
W
M
Site 32
Y269
V
Q
D
T
S
G
T
Y
Y
W
H
I
P
T
G
Site 33
Y270
Q
D
T
S
G
T
Y
Y
W
H
I
P
T
G
T
Site 34
S287
W
E
P
P
G
R
A
S
P
S
Q
G
S
S
P
Site 35
S289
P
P
G
R
A
S
P
S
Q
G
S
S
P
Q
E
Site 36
S293
A
S
P
S
Q
G
S
S
P
Q
E
E
S
Q
L
Site 37
S298
G
S
S
P
Q
E
E
S
Q
L
T
W
T
G
F
Site 38
T301
P
Q
E
E
S
Q
L
T
W
T
G
F
A
H
G
Site 39
S322
E
F
W
K
D
E
P
S
D
E
A
P
M
E
L
Site 40
T340
E
P
E
E
G
T
L
T
F
P
A
Q
S
L
S
Site 41
S345
T
L
T
F
P
A
Q
S
L
S
P
E
P
L
P
Site 42
S347
T
F
P
A
Q
S
L
S
P
E
P
L
P
Q
E
Site 43
T363
E
K
L
P
P
R
N
T
N
P
G
I
K
C
F
Site 44
S390
E
E
L
A
P
G
R
S
S
V
A
V
N
N
C
Site 45
Y403
N
C
I
R
Q
L
S
Y
H
K
N
N
L
H
D
Site 46
S413
N
N
L
H
D
P
M
S
G
G
W
G
E
G
K
Site 47
S438
L
K
L
V
E
P
Q
S
Q
A
L
L
H
A
Q
Site 48
S459
V
W
G
V
G
R
D
S
G
R
E
R
D
F
A
Site 49
Y467
G
R
E
R
D
F
A
Y
V
A
R
D
K
L
T
Site 50
S494
P
A
K
N
I
A
T
S
L
H
E
I
C
S
K
Site 51
S517
R
C
L
V
N
G
L
S
L
D
H
S
K
L
V
Site 52
S521
N
G
L
S
L
D
H
S
K
L
V
D
V
P
F
Site 53
Y547
V
Q
K
F
Q
V
Y
Y
L
G
N
V
P
V
A
Site 54
S571
G
A
L
E
S
V
L
S
S
S
S
R
E
Q
W
Site 55
S572
A
L
E
S
V
L
S
S
S
S
R
E
Q
W
T
Site 56
S573
L
E
S
V
L
S
S
S
S
R
E
Q
W
T
P
Site 57
S574
E
S
V
L
S
S
S
S
R
E
Q
W
T
P
S
Site 58
T579
S
S
S
R
E
Q
W
T
P
S
H
V
S
V
A
Site 59
S581
S
R
E
Q
W
T
P
S
H
V
S
V
A
P
A
Site 60
S584
Q
W
T
P
S
H
V
S
V
A
P
A
T
L
T
Site 61
S610
E
C
R
V
R
F
L
S
F
L
A
V
G
R
D
Site 62
S666
Q
K
C
L
D
A
R
S
Q
A
S
T
S
C
L
Site 63
S669
L
D
A
R
S
Q
A
S
T
S
C
L
P
A
P
Site 64
T670
D
A
R
S
Q
A
S
T
S
C
L
P
A
P
P
Site 65
S671
A
R
S
Q
A
S
T
S
C
L
P
A
P
P
A
Site 66
S680
L
P
A
P
P
A
E
S
V
A
R
R
V
G
W
Site 67
T688
V
A
R
R
V
G
W
T
V
R
R
G
V
Q
S
Site 68
S695
T
V
R
R
G
V
Q
S
L
W
G
S
L
K
P
Site 69
S699
G
V
Q
S
L
W
G
S
L
K
P
K
R
L
G
Site 70
T709
P
K
R
L
G
A
H
T
P
_
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation