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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
TYKY
Full Name:
NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial
Alias:
CI-23kD; Complex I-23kD; NADH dehydrogenase (ubiquinone) Fe-S protein 8; NADH dehydrogenase iron-sulfur 8, mitochondrial; NADH-coenzyme Q reductase; NADH-ubiquinone oxidoreductase 23 kDa; NADH-ubiquinone oxidoreductase 23 kDa subunit; NDUS8; TYKY subunit
Type:
Oxidoreductase; Energy Metabolism - oxidative phosphorylation; EC 1.6.99.3; EC 1.6.5.3; Mitochondrial
Mass (Da):
23687
Number AA:
210
UniProt ID:
O00217
International Prot ID:
IPI00010845
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005739
GO:0005746
GO:0005747
Uniprot
OncoNet
Molecular Function:
GO:0003824
GO:0003954
GO:0005488
PhosphoSite+
KinaseNET
Biological Process:
GO:0006091
GO:0006120
GO:0006461
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T5
_
_
_
M
R
C
L
T
T
P
M
L
L
R
A
Site 2
T6
_
_
M
R
C
L
T
T
P
M
L
L
R
A
L
Site 3
S26
A
G
P
P
G
G
R
S
L
H
S
S
A
V
A
Site 4
S29
P
G
G
R
S
L
H
S
S
A
V
A
A
T
Y
Site 5
S30
G
G
R
S
L
H
S
S
A
V
A
A
T
Y
K
Site 6
Y36
S
S
A
V
A
A
T
Y
K
Y
V
N
M
Q
D
Site 7
Y38
A
V
A
A
T
Y
K
Y
V
N
M
Q
D
P
E
Site 8
S50
D
P
E
M
D
M
K
S
V
T
D
R
A
A
R
Site 9
T52
E
M
D
M
K
S
V
T
D
R
A
A
R
T
L
Site 10
S73
R
G
L
G
M
T
L
S
Y
L
F
R
E
P
A
Site 11
Y84
R
E
P
A
T
I
N
Y
P
F
E
K
G
P
L
Site 12
S92
P
F
E
K
G
P
L
S
P
R
F
R
G
E
H
Site 13
Y104
G
E
H
A
L
R
R
Y
P
S
G
E
E
R
C
Site 14
S106
H
A
L
R
R
Y
P
S
G
E
E
R
C
I
A
Site 15
S137
A
E
P
R
A
D
G
S
R
R
T
T
R
Y
D
Site 16
T140
R
A
D
G
S
R
R
T
T
R
Y
D
I
D
M
Site 17
T141
A
D
G
S
R
R
T
T
R
Y
D
I
D
M
T
Site 18
Y143
G
S
R
R
T
T
R
Y
D
I
D
M
T
K
C
Site 19
S174
E
G
P
N
F
E
F
S
T
E
T
H
E
E
L
Site 20
Y183
E
T
H
E
E
L
L
Y
N
K
E
K
L
L
N
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation