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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
GRM8
Full Name:
Metabotropic glutamate receptor 8
Alias:
GPRC1H, MGLUR8
Type:
Receptor, GPCR protein
Mass (Da):
101741
Number AA:
908
UniProt ID:
O00222
International Prot ID:
IPI00413310
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005887
Uniprot
OncoNet
Molecular Function:
GO:0004930
GO:0008066
PhosphoSite+
KinaseNET
Biological Process:
GO:0007186
GO:0007194
GO:0030818
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S33
T
M
M
Q
R
T
H
S
Q
E
Y
A
H
S
I
Site 2
S39
H
S
Q
E
Y
A
H
S
I
R
V
D
G
D
I
Site 3
Y81
H
R
L
E
A
M
L
Y
A
I
D
Q
I
N
K
Site 4
S94
N
K
D
P
D
L
L
S
N
I
T
L
G
V
R
Site 5
T105
L
G
V
R
I
L
D
T
C
S
R
D
T
Y
A
Site 6
T110
L
D
T
C
S
R
D
T
Y
A
L
E
Q
S
L
Site 7
Y111
D
T
C
S
R
D
T
Y
A
L
E
Q
S
L
T
Site 8
S129
A
L
I
E
K
D
A
S
D
V
K
C
A
N
G
Site 9
T142
N
G
D
P
P
I
F
T
K
P
D
K
I
S
G
Site 10
S175
L
F
K
I
P
Q
I
S
Y
A
S
T
A
P
E
Site 11
S178
I
P
Q
I
S
Y
A
S
T
A
P
E
L
S
D
Site 12
T179
P
Q
I
S
Y
A
S
T
A
P
E
L
S
D
N
Site 13
S184
A
S
T
A
P
E
L
S
D
N
T
R
Y
D
F
Site 14
T187
A
P
E
L
S
D
N
T
R
Y
D
F
F
S
R
Site 15
Y189
E
L
S
D
N
T
R
Y
D
F
F
S
R
V
V
Site 16
S193
N
T
R
Y
D
F
F
S
R
V
V
P
P
D
S
Site 17
S200
S
R
V
V
P
P
D
S
Y
Q
A
Q
A
M
V
Site 18
Y201
R
V
V
P
P
D
S
Y
Q
A
Q
A
M
V
D
Site 19
S219
A
L
G
W
N
Y
V
S
T
L
A
S
E
G
N
Site 20
T220
L
G
W
N
Y
V
S
T
L
A
S
E
G
N
Y
Site 21
S223
N
Y
V
S
T
L
A
S
E
G
N
Y
G
E
S
Site 22
Y227
T
L
A
S
E
G
N
Y
G
E
S
G
V
E
A
Site 23
S250
G
G
V
C
I
A
Q
S
Q
K
I
P
R
E
P
Site 24
Y319
G
S
K
I
A
P
V
Y
Q
Q
E
E
I
A
E
Site 25
S337
T
I
L
P
K
R
A
S
I
D
G
F
D
R
Y
Site 26
Y344
S
I
D
G
F
D
R
Y
F
R
S
R
T
L
A
Site 27
S347
G
F
D
R
Y
F
R
S
R
T
L
A
N
N
R
Site 28
T349
D
R
Y
F
R
S
R
T
L
A
N
N
R
R
N
Site 29
S373
N
F
G
C
K
L
G
S
H
G
K
R
N
S
H
Site 30
S379
G
S
H
G
K
R
N
S
H
I
K
K
C
T
G
Site 31
S394
L
E
R
I
A
R
D
S
S
Y
E
Q
E
G
K
Site 32
S395
E
R
I
A
R
D
S
S
Y
E
Q
E
G
K
V
Site 33
Y396
R
I
A
R
D
S
S
Y
E
Q
E
G
K
V
Q
Site 34
Y427
H
K
D
L
C
P
G
Y
I
G
L
C
P
R
M
Site 35
T436
G
L
C
P
R
M
S
T
I
D
G
K
E
L
L
Site 36
Y445
D
G
K
E
L
L
G
Y
I
R
A
V
N
F
N
Site 37
T457
N
F
N
G
S
A
G
T
P
V
T
F
N
E
N
Site 38
T460
G
S
A
G
T
P
V
T
F
N
E
N
G
D
A
Site 39
Y471
N
G
D
A
P
G
R
Y
D
I
F
Q
Y
Q
I
Site 40
Y476
G
R
Y
D
I
F
Q
Y
Q
I
T
N
K
S
T
Site 41
Y485
I
T
N
K
S
T
E
Y
K
V
I
G
H
W
T
Site 42
T510
Q
W
A
H
R
E
H
T
H
P
A
S
V
C
S
Site 43
S514
R
E
H
T
H
P
A
S
V
C
S
L
P
C
K
Site 44
S517
T
H
P
A
S
V
C
S
L
P
C
K
P
G
E
Site 45
T528
K
P
G
E
R
K
K
T
V
K
G
V
P
C
C
Site 46
Y546
E
R
C
E
G
Y
N
Y
Q
V
D
E
L
S
C
Site 47
S552
N
Y
Q
V
D
E
L
S
C
E
L
C
P
L
D
Site 48
T611
T
F
V
R
Y
N
D
T
P
I
V
R
A
S
G
Site 49
S617
D
T
P
I
V
R
A
S
G
R
E
L
S
Y
V
Site 50
S683
I
F
E
Q
G
K
K
S
V
T
A
P
K
F
I
Site 51
T685
E
Q
G
K
K
S
V
T
A
P
K
F
I
S
P
Site 52
S691
V
T
A
P
K
F
I
S
P
A
S
Q
L
V
I
Site 53
Y725
P
P
H
I
I
I
D
Y
G
E
Q
R
T
L
D
Site 54
T730
I
D
Y
G
E
Q
R
T
L
D
P
E
K
A
R
Site 55
T776
K
T
R
G
V
P
E
T
F
N
E
A
K
P
I
Site 56
S855
N
V
Q
K
R
K
R
S
F
K
A
V
V
T
A
Site 57
T864
K
A
V
V
T
A
A
T
M
Q
S
K
L
I
Q
Site 58
S867
V
T
A
A
T
M
Q
S
K
L
I
Q
K
G
N
Site 59
S883
R
P
N
G
E
V
K
S
E
L
C
E
S
L
E
Site 60
S888
V
K
S
E
L
C
E
S
L
E
T
N
T
S
S
Site 61
T891
E
L
C
E
S
L
E
T
N
T
S
S
T
K
T
Site 62
S894
E
S
L
E
T
N
T
S
S
T
K
T
T
Y
I
Site 63
S895
S
L
E
T
N
T
S
S
T
K
T
T
Y
I
S
Site 64
T898
T
N
T
S
S
T
K
T
T
Y
I
S
Y
S
N
Site 65
T899
N
T
S
S
T
K
T
T
Y
I
S
Y
S
N
H
Site 66
Y900
T
S
S
T
K
T
T
Y
I
S
Y
S
N
H
S
Site 67
S902
S
T
K
T
T
Y
I
S
Y
S
N
H
S
I
_
Site 68
Y903
T
K
T
T
Y
I
S
Y
S
N
H
S
I
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation