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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PSMD12
Full Name:
26S proteasome non-ATPase regulatory subunit 12
Alias:
26S proteasome non-ATPase regulatory 12; 26S proteasome regulatory p55; p55; proteasome (prosome, macropain) 26S subunit, non-ATPase, 12; proteasome (prosome, macropain) 26S, non-ATPase, 12; proteasome 26S non-ATPase 12; proteasome 26S non-ATPase 12 isoform 1 variant; PSD12; Rpn5
Type:
Protease; Proteasome complex
Mass (Da):
52904
Number AA:
455
UniProt ID:
O00232
International Prot ID:
IPI00185374
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005838
Uniprot
OncoNet
Molecular Function:
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0031145
GO:0051436
GO:0051437
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S6
_
_
M
A
D
G
G
S
E
R
A
D
G
R
I
Site 2
Y20
I
V
K
M
E
V
D
Y
S
A
T
V
D
Q
R
Site 3
S21
V
K
M
E
V
D
Y
S
A
T
V
D
Q
R
L
Site 4
T46
R
L
Q
E
V
I
E
T
L
L
S
L
E
K
Q
Site 5
S49
E
V
I
E
T
L
L
S
L
E
K
Q
T
R
T
Site 6
S58
E
K
Q
T
R
T
A
S
D
M
V
S
T
S
R
Site 7
S91
N
E
N
I
M
L
L
S
K
R
R
S
Q
L
K
Site 8
S95
M
L
L
S
K
R
R
S
Q
L
K
Q
A
V
A
Site 9
Y111
M
V
Q
Q
C
C
T
Y
V
E
E
I
T
D
L
Site 10
Y137
M
V
T
E
G
K
I
Y
V
E
I
E
R
A
R
Site 11
T146
E
I
E
R
A
R
L
T
K
T
L
A
T
I
K
Site 12
T148
E
R
A
R
L
T
K
T
L
A
T
I
K
E
Q
Site 13
S176
L
Q
V
E
T
Y
G
S
M
E
K
K
E
R
V
Site 14
T219
K
F
F
Q
E
E
N
T
E
K
L
K
L
K
Y
Site 15
Y226
T
E
K
L
K
L
K
Y
Y
N
L
M
I
Q
L
Site 16
Y227
E
K
L
K
L
K
Y
Y
N
L
M
I
Q
L
D
Site 17
Y240
L
D
Q
H
E
G
S
Y
L
S
I
C
K
H
Y
Site 18
Y251
C
K
H
Y
R
A
I
Y
D
T
P
C
I
Q
A
Site 19
T253
H
Y
R
A
I
Y
D
T
P
C
I
Q
A
E
S
Site 20
S284
A
P
F
D
N
E
Q
S
D
L
V
H
R
I
S
Site 21
S291
S
D
L
V
H
R
I
S
G
D
K
K
L
E
E
Site 22
Y302
K
L
E
E
I
P
K
Y
K
D
L
L
K
L
F
Site 23
T319
M
E
L
M
R
W
S
T
L
V
E
D
Y
G
M
Site 24
Y324
W
S
T
L
V
E
D
Y
G
M
E
L
R
K
G
Site 25
S332
G
M
E
L
R
K
G
S
L
E
S
P
A
T
D
Site 26
S335
L
R
K
G
S
L
E
S
P
A
T
D
V
F
G
Site 27
T338
G
S
L
E
S
P
A
T
D
V
F
G
S
T
E
Site 28
Y369
N
I
R
I
M
A
K
Y
Y
T
R
I
T
M
K
Site 29
Y370
I
R
I
M
A
K
Y
Y
T
R
I
T
M
K
R
Site 30
T374
A
K
Y
Y
T
R
I
T
M
K
R
M
A
Q
L
Site 31
S394
D
E
S
E
A
F
L
S
N
L
V
V
N
K
T
Site 32
T401
S
N
L
V
V
N
K
T
I
F
A
K
V
D
R
Site 33
S434
D
W
S
Q
K
L
N
S
L
M
S
L
V
N
K
Site 34
S437
Q
K
L
N
S
L
M
S
L
V
N
K
T
T
H
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation