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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
CBX4
Full Name:
E3 SUMO-protein ligase CBX4
Alias:
Chromobox 4; Chromobox protein homolog 4; Chromobox protein homologue 4; HPC2; NBP16; NS5ATP1-binding protein 16; Pc2; Polycomb 2
Type:
Transcription, coactivator/corepressor; SUMO conjugating system
Mass (Da):
61368
Number AA:
560
UniProt ID:
O00257
International Prot ID:
IPI00010872
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0000785
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0019899
GO:0003714
PhosphoSite+
KinaseNET
Biological Process:
GO:0006916
GO:0006333
GO:0016568
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y28
I
R
K
G
R
V
E
Y
L
V
K
W
R
G
W
Site 2
T41
G
W
S
P
K
Y
N
T
W
E
P
E
E
N
I
Site 3
Y69
R
Q
E
Q
L
M
G
Y
R
K
R
G
P
K
P
Site 4
S90
V
P
T
F
A
R
R
S
N
V
L
T
G
L
Q
Site 5
T94
A
R
R
S
N
V
L
T
G
L
Q
D
S
S
T
Site 6
S99
V
L
T
G
L
Q
D
S
S
T
D
N
R
A
K
Site 7
T101
T
G
L
Q
D
S
S
T
D
N
R
A
K
L
D
Site 8
Y120
G
K
G
Q
G
H
Q
Y
E
L
N
S
K
K
H
Site 9
Y130
N
S
K
K
H
H
Q
Y
Q
P
H
S
K
E
R
Site 10
S134
H
H
Q
Y
Q
P
H
S
K
E
R
A
G
K
P
Site 11
Y150
P
P
G
K
S
G
K
Y
Y
Y
Q
L
N
S
K
Site 12
Y151
P
G
K
S
G
K
Y
Y
Y
Q
L
N
S
K
K
Site 13
Y152
G
K
S
G
K
Y
Y
Y
Q
L
N
S
K
K
H
Site 14
Y169
Y
Q
P
D
P
K
M
Y
D
L
Q
Y
Q
G
G
Site 15
Y173
P
K
M
Y
D
L
Q
Y
Q
G
G
H
K
E
A
Site 16
S182
G
G
H
K
E
A
P
S
P
T
C
P
D
L
G
Site 17
S192
C
P
D
L
G
A
K
S
H
P
P
D
K
W
A
Site 18
Y207
Q
G
A
G
A
K
G
Y
L
G
A
V
K
P
L
Site 19
S225
A
G
A
P
G
K
G
S
E
K
G
P
P
N
G
Site 20
S267
G
R
I
V
I
V
M
S
K
Y
M
E
N
G
M
Site 21
S291
V
A
E
G
E
A
R
S
P
S
H
K
K
R
A
Site 22
S293
E
G
E
A
R
S
P
S
H
K
K
R
A
A
D
Site 23
T309
R
H
P
P
A
D
R
T
F
K
K
A
A
G
A
Site 24
S333
K
R
R
E
E
E
V
S
G
V
S
D
P
Q
P
Site 25
S336
E
E
E
V
S
G
V
S
D
P
Q
P
Q
D
A
Site 26
S345
P
Q
P
Q
D
A
G
S
R
K
L
S
P
T
K
Site 27
S349
D
A
G
S
R
K
L
S
P
T
K
E
A
F
G
Site 28
T351
G
S
R
K
L
S
P
T
K
E
A
F
G
E
Q
Site 29
T363
G
E
Q
P
L
Q
L
T
T
K
P
D
L
L
A
Site 30
T377
A
W
D
P
A
R
N
T
H
P
P
S
H
H
P
Site 31
S381
A
R
N
T
H
P
P
S
H
H
P
H
P
H
P
Site 32
S407
H
A
V
G
L
N
L
S
H
V
R
K
R
C
L
Site 33
S415
H
V
R
K
R
C
L
S
E
T
H
G
E
R
E
Site 34
T417
R
K
R
C
L
S
E
T
H
G
E
R
E
P
C
Site 35
T429
E
P
C
K
K
R
L
T
A
R
S
I
S
T
P
Site 36
S432
K
K
R
L
T
A
R
S
I
S
T
P
T
C
L
Site 37
S434
R
L
T
A
R
S
I
S
T
P
T
C
L
G
G
Site 38
T435
A
R
S
I
S
T
P
T
C
L
G
G
S
P
A
Site 39
T437
A
R
S
I
S
T
P
T
C
L
G
G
S
P
A
Site 40
S442
T
P
T
C
L
G
G
S
P
A
A
E
R
P
A
Site 41
S467
P
E
V
I
L
L
D
S
D
L
D
E
P
I
D
Site 42
T480
I
D
L
R
C
V
K
T
R
S
E
A
G
E
P
Site 43
S482
L
R
C
V
K
T
R
S
E
A
G
E
P
P
S
Site 44
S490
E
A
G
E
P
P
S
S
L
Q
V
K
P
E
T
Site 45
T497
S
L
Q
V
K
P
E
T
P
A
S
A
A
V
A
Site 46
S529
A
Q
D
E
P
A
E
S
L
S
E
F
K
P
F
Site 47
S531
D
E
P
A
E
S
L
S
E
F
K
P
F
F
G
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation