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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
DFFA
Full Name:
DNA fragmentation factor subunit alpha
Alias:
DFF1; DFF45; DFF-45; DNA fragmentation factor 45 kDa subunit; DNA fragmentation factor, 45 kD, alpha subunit; DNA fragmentation factor, 45kDa, alpha polypeptide; DNAation factor 45 kDa subunit; H13; ICAD; Inhibitor of CAD
Type:
Hydrolase
Mass (Da):
36522
Number AA:
331
UniProt ID:
O00273
International Prot ID:
IPI00010882
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
GO:0005654
Uniprot
OncoNet
Molecular Function:
GO:0004537
GO:0042802
PhosphoSite+
KinaseNET
Biological Process:
GO:0006309
GO:0007242
GO:0043066
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S12
G
D
A
G
V
P
E
S
G
E
I
R
T
L
K
Site 2
T17
P
E
S
G
E
I
R
T
L
K
P
C
L
L
R
Site 3
Y27
P
C
L
L
R
R
N
Y
S
R
E
Q
H
G
V
Site 4
S28
C
L
L
R
R
N
Y
S
R
E
Q
H
G
V
A
Site 5
S37
E
Q
H
G
V
A
A
S
C
L
E
D
L
R
S
Site 6
T68
L
V
L
A
E
D
G
T
I
V
D
D
D
D
Y
Site 7
Y75
T
I
V
D
D
D
D
Y
F
L
C
L
P
S
N
Site 8
Y96
A
S
N
E
K
W
A
Y
N
N
S
D
G
G
T
Site 9
T103
Y
N
N
S
D
G
G
T
A
W
I
S
Q
E
S
Site 10
S107
D
G
G
T
A
W
I
S
Q
E
S
F
D
V
D
Site 11
S110
T
A
W
I
S
Q
E
S
F
D
V
D
E
T
D
Site 12
T116
E
S
F
D
V
D
E
T
D
S
G
A
G
L
K
Site 13
S118
F
D
V
D
E
T
D
S
G
A
G
L
K
W
K
Site 14
S136
R
Q
L
K
E
D
L
S
S
I
I
L
L
S
E
Site 15
S137
Q
L
K
E
D
L
S
S
I
I
L
L
S
E
E
Site 16
S164
L
A
Q
E
L
R
Q
S
C
A
T
V
Q
R
L
Site 17
T167
E
L
R
Q
S
C
A
T
V
Q
R
L
Q
H
T
Site 18
S188
Q
R
E
E
V
R
Q
S
K
Q
L
L
Q
L
Y
Site 19
Y195
S
K
Q
L
L
Q
L
Y
L
Q
A
L
E
K
E
Site 20
S204
Q
A
L
E
K
E
G
S
L
L
S
K
Q
E
E
Site 21
S207
E
K
E
G
S
L
L
S
K
Q
E
E
S
K
A
Site 22
S228
D
A
V
D
T
G
I
S
R
E
T
S
S
D
V
Site 23
T231
D
T
G
I
S
R
E
T
S
S
D
V
A
L
A
Site 24
S232
T
G
I
S
R
E
T
S
S
D
V
A
L
A
S
Site 25
S233
G
I
S
R
E
T
S
S
D
V
A
L
A
S
H
Site 26
S254
E
K
Q
A
P
E
L
S
L
S
S
Q
D
L
E
Site 27
S256
Q
A
P
E
L
S
L
S
S
Q
D
L
E
L
V
Site 28
S257
A
P
E
L
S
L
S
S
Q
D
L
E
L
V
T
Site 29
T300
L
A
L
R
L
Q
Q
T
Q
S
L
H
S
L
R
Site 30
S302
L
R
L
Q
Q
T
Q
S
L
H
S
L
R
S
I
Site 31
S305
Q
Q
T
Q
S
L
H
S
L
R
S
I
S
A
S
Site 32
S308
Q
S
L
H
S
L
R
S
I
S
A
S
K
A
S
Site 33
S310
L
H
S
L
R
S
I
S
A
S
K
A
S
P
P
Site 34
S312
S
L
R
S
I
S
A
S
K
A
S
P
P
G
D
Site 35
S315
S
I
S
A
S
K
A
S
P
P
G
D
L
Q
N
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation