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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
HIP1
Full Name:
Huntingtin-interacting protein 1
Alias:
Huntingtin-interacting protein I
Type:
Mass (Da):
116203
Number AA:
1037
UniProt ID:
O00291
International Prot ID:
IPI00782965
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0000267
GO:0005624
GO:0005626
Uniprot
OncoNet
Molecular Function:
GO:0003779
GO:0005198
GO:0005200
PhosphoSite+
KinaseNET
Biological Process:
GO:0006461
GO:0006810
GO:0006897
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S20
N
P
L
P
K
V
L
S
R
R
G
V
G
A
G
Site 2
S35
L
E
A
A
E
R
E
S
F
E
R
T
Q
T
V
Site 3
T39
E
R
E
S
F
E
R
T
Q
T
V
S
I
N
K
Site 4
T41
E
S
F
E
R
T
Q
T
V
S
I
N
K
A
I
Site 5
S43
F
E
R
T
Q
T
V
S
I
N
K
A
I
N
T
Site 6
S78
K
G
A
Q
T
F
W
S
V
V
N
R
L
P
L
Site 7
S114
H
P
N
V
L
K
D
S
L
R
Y
R
N
E
L
Site 8
S122
L
R
Y
R
N
E
L
S
D
M
S
R
M
W
G
Site 9
Y135
W
G
H
L
S
E
G
Y
G
Q
L
C
S
I
Y
Site 10
Y152
L
L
R
T
K
M
E
Y
H
T
K
N
P
R
F
Site 11
T154
R
T
K
M
E
Y
H
T
K
N
P
R
F
P
G
Site 12
S166
F
P
G
N
L
Q
M
S
D
R
Q
L
D
E
A
Site 13
S176
Q
L
D
E
A
G
E
S
D
V
N
N
F
F
Q
Site 14
S211
N
S
L
D
M
S
R
S
V
S
V
T
A
A
G
Site 15
Y238
D
C
S
H
L
Y
D
Y
T
V
K
L
L
F
K
Site 16
Y274
T
K
L
K
D
L
F
Y
R
S
S
N
L
Q
Y
Site 17
S277
K
D
L
F
Y
R
S
S
N
L
Q
Y
F
K
R
Site 18
Y281
Y
R
S
S
N
L
Q
Y
F
K
R
L
I
Q
I
Site 19
S302
P
P
N
F
L
R
A
S
A
L
S
E
H
I
S
Site 20
S320
V
I
P
A
E
A
S
S
P
D
S
E
P
V
L
Site 21
S323
A
E
A
S
S
P
D
S
E
P
V
L
E
K
D
Site 22
S353
K
F
D
D
I
F
G
S
S
F
S
S
D
P
F
Site 23
S354
F
D
D
I
F
G
S
S
F
S
S
D
P
F
N
Site 24
S356
D
I
F
G
S
S
F
S
S
D
P
F
N
F
N
Site 25
S357
I
F
G
S
S
F
S
S
D
P
F
N
F
N
S
Site 26
S364
S
D
P
F
N
F
N
S
Q
N
G
V
N
K
D
Site 27
Y381
D
H
L
I
E
R
L
Y
R
E
I
S
G
L
K
Site 28
S385
E
R
L
Y
R
E
I
S
G
L
K
A
Q
L
E
Site 29
T396
A
Q
L
E
N
M
K
T
E
S
Q
R
V
V
L
Site 30
S398
L
E
N
M
K
T
E
S
Q
R
V
V
L
Q
L
Site 31
T447
L
R
R
Q
R
E
D
T
E
K
A
Q
R
S
L
Site 32
S453
D
T
E
K
A
Q
R
S
L
S
E
I
E
R
K
Site 33
S455
E
K
A
Q
R
S
L
S
E
I
E
R
K
A
Q
Site 34
S469
Q
A
N
E
Q
R
Y
S
K
L
K
E
K
Y
S
Site 35
S476
S
K
L
K
E
K
Y
S
E
L
V
Q
N
H
A
Site 36
S516
E
K
K
E
L
E
D
S
L
E
R
I
S
D
Q
Site 37
S521
E
D
S
L
E
R
I
S
D
Q
G
Q
R
K
T
Site 38
T528
S
D
Q
G
Q
R
K
T
Q
E
Q
L
E
V
L
Site 39
S537
E
Q
L
E
V
L
E
S
L
K
Q
E
L
A
T
Site 40
S545
L
K
Q
E
L
A
T
S
Q
R
E
L
Q
V
L
Site 41
S555
E
L
Q
V
L
Q
G
S
L
E
T
S
A
Q
S
Site 42
S559
L
Q
G
S
L
E
T
S
A
Q
S
E
A
N
W
Site 43
S579
E
L
E
K
E
R
D
S
L
V
S
G
A
A
H
Site 44
S582
K
E
R
D
S
L
V
S
G
A
A
H
R
E
E
Site 45
S592
A
H
R
E
E
E
L
S
A
L
R
K
E
L
Q
Site 46
T601
L
R
K
E
L
Q
D
T
Q
L
K
L
A
S
T
Site 47
S607
D
T
Q
L
K
L
A
S
T
E
E
S
M
C
Q
Site 48
S611
K
L
A
S
T
E
E
S
M
C
Q
L
A
K
D
Site 49
S649
L
E
E
P
P
L
I
S
C
A
G
S
A
D
H
Site 50
S676
E
Q
L
E
K
S
W
S
Q
Y
L
A
C
P
E
Site 51
Y678
L
E
K
S
W
S
Q
Y
L
A
C
P
E
D
I
Site 52
S720
A
P
P
E
P
A
D
S
L
T
E
A
C
K
Q
Site 53
T722
P
E
P
A
D
S
L
T
E
A
C
K
Q
Y
G
Site 54
Y728
L
T
E
A
C
K
Q
Y
G
R
E
T
L
A
Y
Site 55
T732
C
K
Q
Y
G
R
E
T
L
A
Y
L
A
S
L
Site 56
Y735
Y
G
R
E
T
L
A
Y
L
A
S
L
E
E
E
Site 57
S738
E
T
L
A
Y
L
A
S
L
E
E
E
G
S
L
Site 58
S744
A
S
L
E
E
E
G
S
L
E
N
A
D
S
T
Site 59
S750
G
S
L
E
N
A
D
S
T
A
M
R
N
C
L
Site 60
T751
S
L
E
N
A
D
S
T
A
M
R
N
C
L
S
Site 61
S806
A
R
I
E
E
M
L
S
K
S
R
A
G
D
T
Site 62
S808
I
E
E
M
L
S
K
S
R
A
G
D
T
G
V
Site 63
S851
L
Q
R
E
I
V
E
S
G
R
G
T
A
S
P
Site 64
T855
I
V
E
S
G
R
G
T
A
S
P
K
E
F
Y
Site 65
S857
E
S
G
R
G
T
A
S
P
K
E
F
Y
A
K
Site 66
T869
Y
A
K
N
S
R
W
T
E
G
L
I
S
A
S
Site 67
S874
R
W
T
E
G
L
I
S
A
S
K
A
V
G
W
Site 68
S929
K
V
K
A
D
K
D
S
P
N
L
A
Q
L
Q
Site 69
S958
A
S
T
I
S
G
K
S
Q
I
E
E
T
D
N
Site 70
S970
T
D
N
M
D
F
S
S
M
T
L
T
Q
I
K
Site 71
T974
D
F
S
S
M
T
L
T
Q
I
K
R
Q
E
M
Site 72
S983
I
K
R
Q
E
M
D
S
Q
V
R
V
L
E
L
Site 73
Y1009
G
E
L
R
K
K
H
Y
E
L
A
G
V
A
E
Site 74
S1025
W
E
E
G
T
E
A
S
P
P
T
L
Q
E
V
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation