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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
LEFTY2
Full Name:
Left-right determination factor 2
Alias:
EBAF, LEFTA, LEFTYA, TGFB4
Type:
Secreted protein
Mass (Da):
40920
Number AA:
366
UniProt ID:
O00292
International Prot ID:
IPI00010893
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005615
GO:0031093
Uniprot
OncoNet
Molecular Function:
GO:0005125
GO:0008083
GO:0005160
PhosphoSite+
KinaseNET
Biological Process:
GO:0016049
GO:0007309
GO:0007179
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S30
T
E
E
Q
L
L
G
S
L
L
R
Q
L
Q
L
Site 2
Y61
P
A
H
V
R
A
Q
Y
V
V
L
L
R
R
S
Site 3
S68
Y
V
V
L
L
R
R
S
H
G
D
R
S
R
G
Site 4
S73
R
R
S
H
G
D
R
S
R
G
K
R
F
S
Q
Site 5
S79
R
S
R
G
K
R
F
S
Q
S
F
R
E
V
A
Site 6
S81
R
G
K
R
F
S
Q
S
F
R
E
V
A
G
R
Site 7
S111
E
Q
R
L
P
P
N
S
E
L
V
Q
A
V
L
Site 8
S137
L
H
R
H
G
R
L
S
P
R
S
A
Q
A
R
Site 9
S140
H
G
R
L
S
P
R
S
A
Q
A
R
V
T
V
Site 10
T146
R
S
A
Q
A
R
V
T
V
E
W
L
R
V
R
Site 11
S157
L
R
V
R
D
D
G
S
N
R
T
S
L
I
D
Site 12
S161
D
D
G
S
N
R
T
S
L
I
D
S
R
L
V
Site 13
S165
N
R
T
S
L
I
D
S
R
L
V
S
V
H
E
Site 14
S169
L
I
D
S
R
L
V
S
V
H
E
S
G
W
K
Site 15
S173
R
L
V
S
V
H
E
S
G
W
K
A
F
D
V
Site 16
S191
V
N
F
W
Q
Q
L
S
R
P
R
Q
P
L
L
Site 17
S202
Q
P
L
L
L
Q
V
S
V
Q
R
E
H
L
G
Site 18
S213
E
H
L
G
P
L
A
S
G
A
H
K
L
V
R
Site 19
Y245
H
T
L
D
L
R
D
Y
G
A
Q
G
D
C
D
Site 20
Y269
R
C
C
R
Q
E
M
Y
I
D
L
Q
G
M
K
Site 21
T296
L
A
Y
E
C
V
G
T
C
Q
Q
P
P
E
A
Site 22
S319
G
P
R
Q
C
I
A
S
E
T
A
S
L
P
M
Site 23
T336
S
I
K
E
G
G
R
T
R
P
Q
V
V
S
L
Site 24
S342
R
T
R
P
Q
V
V
S
L
P
N
M
R
V
Q
Site 25
S352
N
M
R
V
Q
K
C
S
C
A
S
D
G
A
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation