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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
TNFRSF11B
Full Name:
Tumor necrosis factor receptor superfamily member 11B
Alias:
Osteoclastogenesis inhibitory factor;Osteoprotegerin
Type:
Mass (Da):
46040
Number AA:
401
UniProt ID:
O00300
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T19
L
D
I
S
I
K
W
T
T
Q
E
T
F
P
P
Site 2
T20
D
I
S
I
K
W
T
T
Q
E
T
F
P
P
K
Site 3
T23
I
K
W
T
T
Q
E
T
F
P
P
K
Y
L
H
Site 4
Y28
Q
E
T
F
P
P
K
Y
L
H
Y
D
E
E
T
Site 5
Y31
F
P
P
K
Y
L
H
Y
D
E
E
T
S
H
Q
Site 6
Y82
H
T
S
D
E
C
L
Y
C
S
P
V
C
K
E
Site 7
S84
S
D
E
C
L
Y
C
S
P
V
C
K
E
L
Q
Site 8
Y92
P
V
C
K
E
L
Q
Y
V
K
Q
E
C
N
R
Site 9
Y112
C
E
C
K
E
G
R
Y
L
E
I
E
F
C
L
Site 10
T140
A
G
T
P
E
R
N
T
V
C
K
R
C
P
D
Site 11
S151
R
C
P
D
G
F
F
S
N
E
T
S
S
K
A
Site 12
T154
D
G
F
F
S
N
E
T
S
S
K
A
P
C
R
Site 13
S155
G
F
F
S
N
E
T
S
S
K
A
P
C
R
K
Site 14
T164
K
A
P
C
R
K
H
T
N
C
S
V
F
G
L
Site 15
S186
A
T
H
D
N
I
C
S
G
N
S
E
S
T
Q
Site 16
S191
I
C
S
G
N
S
E
S
T
Q
K
C
G
I
D
Site 17
T230
L
V
D
N
L
P
G
T
K
V
N
A
E
S
V
Site 18
S236
G
T
K
V
N
A
E
S
V
E
R
I
K
R
Q
Site 19
S245
E
R
I
K
R
Q
H
S
S
Q
E
Q
T
F
Q
Site 20
S246
R
I
K
R
Q
H
S
S
Q
E
Q
T
F
Q
L
Site 21
T250
Q
H
S
S
Q
E
Q
T
F
Q
L
L
K
L
W
Site 22
T291
H
I
G
H
A
N
L
T
F
E
Q
L
R
S
L
Site 23
S297
L
T
F
E
Q
L
R
S
L
M
E
S
L
P
G
Site 24
S301
Q
L
R
S
L
M
E
S
L
P
G
K
K
V
G
Site 25
S330
D
Q
I
L
K
L
L
S
L
W
R
I
K
N
G
Site 26
T341
I
K
N
G
D
Q
D
T
L
K
G
L
M
H
A
Site 27
T354
H
A
L
K
H
S
K
T
Y
H
F
P
K
T
V
Site 28
Y355
A
L
K
H
S
K
T
Y
H
F
P
K
T
V
T
Site 29
T360
K
T
Y
H
F
P
K
T
V
T
Q
S
L
K
K
Site 30
T362
Y
H
F
P
K
T
V
T
Q
S
L
K
K
T
I
Site 31
S364
F
P
K
T
V
T
Q
S
L
K
K
T
I
R
F
Site 32
T368
V
T
Q
S
L
K
K
T
I
R
F
L
H
S
F
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation