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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
eIF3-epsilon
Full Name:
Eukaryotic translation initiation factor 3 subunit F
Alias:
EIF-3 epsilon; EIF3 p47 subunit; EIF3f; EIF3-p47; EIF3S5; Eukaryotic translation initiation factor 3, subunit F; IF35
Type:
Protein synthesis protein, Translation
Mass (Da):
37564
Number AA:
357
UniProt ID:
O00303
International Prot ID:
IPI00654777
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
GO:0005852
Uniprot
OncoNet
Molecular Function:
GO:0005515
GO:0003743
PhosphoSite+
KinaseNET
Biological Process:
GO:0006413
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S46
P
A
A
A
P
A
S
S
S
D
P
A
A
A
A
Site 2
T62
A
T
A
A
P
G
Q
T
P
A
S
A
Q
A
P
Site 3
S65
A
P
G
Q
T
P
A
S
A
Q
A
P
A
Q
T
Site 4
T72
S
A
Q
A
P
A
Q
T
P
A
P
A
L
P
G
Site 5
S105
I
L
A
S
I
V
D
S
Y
E
R
R
N
E
G
Site 6
Y106
L
A
S
I
V
D
S
Y
E
R
R
N
E
G
A
Site 7
T119
G
A
A
R
V
I
G
T
L
L
G
T
V
D
K
Site 8
T132
D
K
H
S
V
E
V
T
N
C
F
S
V
P
H
Site 9
S164
Y
E
L
H
K
K
V
S
P
N
E
L
I
L
G
Site 10
T180
Y
A
T
G
H
D
I
T
E
H
S
V
L
I
H
Site 11
Y189
H
S
V
L
I
H
E
Y
Y
S
R
E
A
P
N
Site 12
Y190
S
V
L
I
H
E
Y
Y
S
R
E
A
P
N
P
Site 13
T201
A
P
N
P
I
H
L
T
V
D
T
S
L
Q
N
Site 14
S205
I
H
L
T
V
D
T
S
L
Q
N
G
R
M
S
Site 15
S212
S
L
Q
N
G
R
M
S
I
K
A
Y
V
S
T
Site 16
Y216
G
R
M
S
I
K
A
Y
V
S
T
L
M
G
V
Site 17
Y241
P
L
T
V
K
Y
A
Y
Y
D
T
E
R
I
G
Site 18
Y242
L
T
V
K
Y
A
Y
Y
D
T
E
R
I
G
V
Site 19
T244
V
K
Y
A
Y
Y
D
T
E
R
I
G
V
D
L
Site 20
T255
G
V
D
L
I
M
K
T
C
F
S
P
N
R
V
Site 21
S258
L
I
M
K
T
C
F
S
P
N
R
V
I
G
L
Site 22
S266
P
N
R
V
I
G
L
S
S
D
L
Q
Q
V
G
Site 23
S267
N
R
V
I
G
L
S
S
D
L
Q
Q
V
G
G
Site 24
S284
A
R
I
Q
D
A
L
S
T
V
L
Q
Y
A
E
Site 25
S295
Q
Y
A
E
D
V
L
S
G
K
V
S
A
D
N
Site 26
S299
D
V
L
S
G
K
V
S
A
D
N
T
V
G
R
Site 27
T303
G
K
V
S
A
D
N
T
V
G
R
F
L
M
S
Site 28
T325
I
V
P
D
D
F
E
T
M
L
N
S
N
I
N
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation