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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
CACNB4
Full Name:
Voltage-dependent L-type calcium channel subunit beta-4
Alias:
CAB4; CACB4; CACNLB4; Calcium channel voltage-dependent subunit beta 4; Calcium channel, voltage-dependent, beta 4 subunit; EJM4; Voltage-dependent L-type calcium channel beta-4 subunit; VSCC, L type, beta 4
Type:
Channel protein, calcium
Mass (Da):
58169
Number AA:
520
UniProt ID:
O00305
International Prot ID:
IPI00011258
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
GO:0009898
GO:0005886
Uniprot
OncoNet
Molecular Function:
GO:0005509
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0006816
GO:0051925
Phosida
TranscriptoNet
STRING
Kinexus Products
Voltage-dependent L-type calcium channel subunit beta-4 pan-specific antibody AB-NN223-1#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-NN223-1
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S17
G
T
A
D
G
P
H
S
P
T
S
Q
V
A
R
Site 2
S20
D
G
P
H
S
P
T
S
Q
V
A
R
G
T
T
Site 3
T26
T
S
Q
V
A
R
G
T
T
T
R
R
S
R
L
Site 4
T27
S
Q
V
A
R
G
T
T
T
R
R
S
R
L
K
Site 5
T28
Q
V
A
R
G
T
T
T
R
R
S
R
L
K
R
Site 6
S31
R
G
T
T
T
R
R
S
R
L
K
R
S
D
G
Site 7
S36
R
R
S
R
L
K
R
S
D
G
S
T
T
S
T
Site 8
S39
R
L
K
R
S
D
G
S
T
T
S
T
S
F
I
Site 9
T40
L
K
R
S
D
G
S
T
T
S
T
S
F
I
L
Site 10
T41
K
R
S
D
G
S
T
T
S
T
S
F
I
L
R
Site 11
S42
R
S
D
G
S
T
T
S
T
S
F
I
L
R
Q
Site 12
T43
S
D
G
S
T
T
S
T
S
F
I
L
R
Q
G
Site 13
S44
D
G
S
T
T
S
T
S
F
I
L
R
Q
G
S
Site 14
S51
S
F
I
L
R
Q
G
S
A
D
S
Y
T
S
R
Site 15
S54
L
R
Q
G
S
A
D
S
Y
T
S
R
P
S
D
Site 16
Y55
R
Q
G
S
A
D
S
Y
T
S
R
P
S
D
S
Site 17
T56
Q
G
S
A
D
S
Y
T
S
R
P
S
D
S
D
Site 18
S57
G
S
A
D
S
Y
T
S
R
P
S
D
S
D
V
Site 19
S60
D
S
Y
T
S
R
P
S
D
S
D
V
S
L
E
Site 20
S62
Y
T
S
R
P
S
D
S
D
V
S
L
E
E
D
Site 21
S65
R
P
S
D
S
D
V
S
L
E
E
D
R
E
A
Site 22
T99
P
V
A
F
A
V
K
T
N
V
S
Y
C
G
A
Site 23
S102
F
A
V
K
T
N
V
S
Y
C
G
A
L
D
E
Site 24
Y103
A
V
K
T
N
V
S
Y
C
G
A
L
D
E
D
Site 25
S115
D
E
D
V
P
V
P
S
T
A
I
S
F
D
A
Site 26
T116
E
D
V
P
V
P
S
T
A
I
S
F
D
A
K
Site 27
S153
C
E
I
G
F
I
P
S
P
L
R
L
E
N
I
Site 28
S176
G
R
F
H
G
G
K
S
S
G
N
S
S
S
S
Site 29
S177
R
F
H
G
G
K
S
S
G
N
S
S
S
S
L
Site 30
S180
G
G
K
S
S
G
N
S
S
S
S
L
G
E
M
Site 31
S181
G
K
S
S
G
N
S
S
S
S
L
G
E
M
V
Site 32
S182
K
S
S
G
N
S
S
S
S
L
G
E
M
V
S
Site 33
S183
S
S
G
N
S
S
S
S
L
G
E
M
V
S
G
Site 34
S189
S
S
L
G
E
M
V
S
G
T
F
R
A
T
P
Site 35
T191
L
G
E
M
V
S
G
T
F
R
A
T
P
T
S
Site 36
T195
V
S
G
T
F
R
A
T
P
T
S
T
A
K
Q
Site 37
S198
T
F
R
A
T
P
T
S
T
A
K
Q
K
Q
K
Site 38
Y213
V
T
E
H
I
P
P
Y
D
V
V
P
S
M
R
Site 39
Y232
V
G
P
S
L
K
G
Y
E
V
T
D
M
M
Q
Site 40
S255
H
R
F
D
G
R
I
S
I
T
R
V
T
A
D
Site 41
S269
D
I
S
L
A
K
R
S
V
L
N
N
P
S
K
Site 42
S275
R
S
V
L
N
N
P
S
K
R
A
I
I
E
R
Site 43
S283
K
R
A
I
I
E
R
S
N
T
R
S
S
L
A
Site 44
T285
A
I
I
E
R
S
N
T
R
S
S
L
A
E
V
Site 45
S287
I
E
R
S
N
T
R
S
S
L
A
E
V
Q
S
Site 46
S288
E
R
S
N
T
R
S
S
L
A
E
V
Q
S
E
Site 47
S294
S
S
L
A
E
V
Q
S
E
I
E
R
I
F
E
Site 48
S338
I
V
H
V
K
V
S
S
P
K
V
L
Q
R
L
Site 49
S348
V
L
Q
R
L
I
K
S
R
G
K
S
Q
S
K
Site 50
S352
L
I
K
S
R
G
K
S
Q
S
K
H
L
N
V
Site 51
S354
K
S
R
G
K
S
Q
S
K
H
L
N
V
Q
L
Site 52
Y394
A
C
E
H
L
G
E
Y
L
E
A
Y
W
R
A
Site 53
Y398
L
G
E
Y
L
E
A
Y
W
R
A
T
H
T
T
Site 54
T402
L
E
A
Y
W
R
A
T
H
T
T
S
S
T
P
Site 55
T404
A
Y
W
R
A
T
H
T
T
S
S
T
P
M
T
Site 56
T405
Y
W
R
A
T
H
T
T
S
S
T
P
M
T
P
Site 57
S406
W
R
A
T
H
T
T
S
S
T
P
M
T
P
L
Site 58
S407
R
A
T
H
T
T
S
S
T
P
M
T
P
L
L
Site 59
T408
A
T
H
T
T
S
S
T
P
M
T
P
L
L
G
Site 60
T411
T
T
S
S
T
P
M
T
P
L
L
G
R
N
L
Site 61
S420
L
L
G
R
N
L
G
S
T
A
L
S
P
Y
P
Site 62
T421
L
G
R
N
L
G
S
T
A
L
S
P
Y
P
T
Site 63
S424
N
L
G
S
T
A
L
S
P
Y
P
T
A
I
S
Site 64
S431
S
P
Y
P
T
A
I
S
G
L
Q
S
Q
R
M
Site 65
S435
T
A
I
S
G
L
Q
S
Q
R
M
R
H
S
N
Site 66
S441
Q
S
Q
R
M
R
H
S
N
H
S
T
E
N
S
Site 67
S444
R
M
R
H
S
N
H
S
T
E
N
S
P
I
E
Site 68
T445
M
R
H
S
N
H
S
T
E
N
S
P
I
E
R
Site 69
S448
S
N
H
S
T
E
N
S
P
I
E
R
R
S
L
Site 70
S454
N
S
P
I
E
R
R
S
L
M
T
S
D
E
N
Site 71
T457
I
E
R
R
S
L
M
T
S
D
E
N
Y
H
N
Site 72
S458
E
R
R
S
L
M
T
S
D
E
N
Y
H
N
E
Site 73
Y462
L
M
T
S
D
E
N
Y
H
N
E
R
A
R
K
Site 74
S470
H
N
E
R
A
R
K
S
R
N
R
L
S
S
S
Site 75
S475
R
K
S
R
N
R
L
S
S
S
S
Q
H
S
R
Site 76
S476
K
S
R
N
R
L
S
S
S
S
Q
H
S
R
D
Site 77
S477
S
R
N
R
L
S
S
S
S
Q
H
S
R
D
H
Site 78
S478
R
N
R
L
S
S
S
S
Q
H
S
R
D
H
Y
Site 79
S481
L
S
S
S
S
Q
H
S
R
D
H
Y
P
L
V
Site 80
Y485
S
Q
H
S
R
D
H
Y
P
L
V
E
E
D
Y
Site 81
Y492
Y
P
L
V
E
E
D
Y
P
D
S
Y
Q
D
T
Site 82
S495
V
E
E
D
Y
P
D
S
Y
Q
D
T
Y
K
P
Site 83
Y496
E
E
D
Y
P
D
S
Y
Q
D
T
Y
K
P
H
Site 84
T499
Y
P
D
S
Y
Q
D
T
Y
K
P
H
R
N
R
Site 85
Y500
P
D
S
Y
Q
D
T
Y
K
P
H
R
N
R
G
Site 86
S508
K
P
H
R
N
R
G
S
P
G
G
Y
S
H
D
Site 87
Y512
N
R
G
S
P
G
G
Y
S
H
D
S
R
H
R
Site 88
S513
R
G
S
P
G
G
Y
S
H
D
S
R
H
R
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation