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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PIK3CD
Full Name:
Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta isoform
Alias:
EC 2.7.1.153; P110D; P110delta; P11D; Phosphatidylinositol 3-kinase, catalytic, delta polypeptide; Phosphoinositide-3-kinase C; Phosphoinositide-3-kinase, catalytic, delta polypeptide; PI3K; PI3K P110-delta; PI3-kinase p110 delta; PK3CD; PtdIns- 3-kinase p110; PtdIns-3-kinase p110
Type:
Kinase, lipid; Carbohydrate Metabolism - inositol phosphate; EC 2.7.1.153
Mass (Da):
119479
Number AA:
1044
UniProt ID:
O00329
International Prot ID:
IPI00298410
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005942
Uniprot
OncoNet
Molecular Function:
GO:0016303
GO:0005524
GO:0046934
PhosphoSite+
KinaseNET
Biological Process:
GO:0046854
GO:0048015
GO:0006468
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S19
W
T
K
E
E
N
Q
S
V
V
V
D
F
L
L
Site 2
S37
V
Y
L
N
F
P
V
S
R
N
A
N
L
S
T
Site 3
S43
V
S
R
N
A
N
L
S
T
I
K
Q
L
L
W
Site 4
T44
S
R
N
A
N
L
S
T
I
K
Q
L
L
W
H
Site 5
Y55
L
L
W
H
R
A
Q
Y
E
P
L
F
H
M
L
Site 6
S130
K
G
L
H
E
F
D
S
L
C
D
P
E
V
N
Site 7
Y165
G
W
E
A
W
L
Q
Y
S
F
P
L
Q
L
E
Site 8
S174
F
P
L
Q
L
E
P
S
A
Q
T
W
G
P
G
Site 9
T182
A
Q
T
W
G
P
G
T
L
R
L
P
N
R
A
Site 10
S202
K
F
E
G
S
E
E
S
F
T
F
Q
V
S
T
Site 11
T204
E
G
S
E
E
S
F
T
F
Q
V
S
T
K
D
Site 12
Y239
L
V
E
Q
P
E
D
Y
T
L
Q
V
N
G
R
Site 13
T240
V
E
Q
P
E
D
Y
T
L
Q
V
N
G
R
H
Site 14
Y249
Q
V
N
G
R
H
E
Y
L
Y
G
S
Y
P
L
Site 15
Y251
N
G
R
H
E
Y
L
Y
G
S
Y
P
L
C
Q
Site 16
Y254
H
E
Y
L
Y
G
S
Y
P
L
C
Q
F
Q
Y
Site 17
S312
P
I
P
A
K
K
P
S
S
V
S
L
W
S
L
Site 18
S313
I
P
A
K
K
P
S
S
V
S
L
W
S
L
E
Site 19
S315
A
K
K
P
S
S
V
S
L
W
S
L
E
Q
P
Site 20
S318
P
S
S
V
S
L
W
S
L
E
Q
P
F
R
I
Site 21
T357
G
N
E
M
L
C
K
T
V
S
S
S
E
V
S
Site 22
S367
S
S
E
V
S
V
C
S
E
P
V
W
K
Q
R
Site 23
S406
E
K
A
K
K
A
R
S
T
K
K
K
S
K
K
Site 24
T407
K
A
K
K
A
R
S
T
K
K
K
S
K
K
A
Site 25
S411
A
R
S
T
K
K
K
S
K
K
A
D
C
P
I
Site 26
Y428
A
N
L
M
L
F
D
Y
K
D
Q
L
K
T
G
Site 27
T434
D
Y
K
D
Q
L
K
T
G
E
R
C
L
Y
M
Site 28
Y440
K
T
G
E
R
C
L
Y
M
W
P
S
V
P
D
Site 29
S444
R
C
L
Y
M
W
P
S
V
P
D
E
K
G
E
Site 30
T456
K
G
E
L
L
N
P
T
G
T
V
R
S
N
P
Site 31
T458
E
L
L
N
P
T
G
T
V
R
S
N
P
N
T
Site 32
S461
N
P
T
G
T
V
R
S
N
P
N
T
D
S
A
Site 33
T465
T
V
R
S
N
P
N
T
D
S
A
A
A
L
L
Site 34
S467
R
S
N
P
N
T
D
S
A
A
A
L
L
I
C
Site 35
Y484
E
V
A
P
H
P
V
Y
Y
P
A
L
E
K
I
Site 36
Y485
V
A
P
H
P
V
Y
Y
P
A
L
E
K
I
L
Site 37
S498
I
L
E
L
G
R
H
S
E
C
V
H
V
T
E
Site 38
S520
E
I
L
E
R
R
G
S
G
E
L
Y
E
H
E
Site 39
Y524
R
R
G
S
G
E
L
Y
E
H
E
K
D
L
V
Site 40
T553
L
A
R
L
L
L
V
T
K
W
N
K
H
E
D
Site 41
S599
V
G
S
F
A
I
K
S
L
R
K
L
T
D
D
Site 42
T604
I
K
S
L
R
K
L
T
D
D
E
L
F
Q
Y
Site 43
Y621
Q
L
V
Q
V
L
K
Y
E
S
Y
L
D
C
E
Site 44
Y624
Q
V
L
K
Y
E
S
Y
L
D
C
E
L
T
K
Site 45
T630
S
Y
L
D
C
E
L
T
K
F
L
L
D
R
A
Site 46
Y671
F
G
L
I
L
E
A
Y
C
R
G
S
T
H
H
Site 47
S690
M
K
Q
G
E
A
L
S
K
L
K
A
L
N
D
Site 48
T706
V
K
L
S
S
Q
K
T
P
K
P
Q
T
K
E
Site 49
S729
E
A
Y
L
E
A
L
S
H
L
Q
S
P
L
D
Site 50
S733
E
A
L
S
H
L
Q
S
P
L
D
P
S
T
L
Site 51
S764
K
P
L
W
I
M
Y
S
N
E
E
A
G
S
G
Site 52
S770
Y
S
N
E
E
A
G
S
G
G
S
V
G
I
I
Site 53
S773
E
E
A
G
S
G
G
S
V
G
I
I
F
K
N
Site 54
T811
E
G
L
D
L
R
M
T
P
Y
G
C
L
P
T
Site 55
Y813
L
D
L
R
M
T
P
Y
G
C
L
P
T
G
D
Site 56
S842
A
N
I
Q
L
N
K
S
N
M
A
A
T
A
A
Site 57
S861
A
L
L
N
W
L
K
S
K
N
P
G
E
A
L
Site 58
S896
L
G
I
G
D
R
H
S
D
N
I
M
I
R
E
Site 59
T935
E
R
V
P
F
I
L
T
Y
D
F
V
H
V
I
Site 60
Y936
R
V
P
F
I
L
T
Y
D
F
V
H
V
I
Q
Site 61
Y959
K
F
E
R
F
R
G
Y
C
E
R
A
Y
T
I
Site 62
Y964
R
G
Y
C
E
R
A
Y
T
I
L
R
R
H
G
Site 63
T965
G
Y
C
E
R
A
Y
T
I
L
R
R
H
G
L
Site 64
S990
A
A
G
L
P
E
L
S
C
S
K
D
I
Q
Y
Site 65
S992
G
L
P
E
L
S
C
S
K
D
I
Q
Y
L
K
Site 66
Y997
S
C
S
K
D
I
Q
Y
L
K
D
S
L
A
L
Site 67
S1001
D
I
Q
Y
L
K
D
S
L
A
L
G
K
T
E
Site 68
T1007
D
S
L
A
L
G
K
T
E
E
E
A
L
K
H
Site 69
S1039
N
W
L
A
H
N
V
S
K
D
N
R
Q
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation