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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PDHX
Full Name:
Pyruvate dehydrogenase protein X component, mitochondrial
Alias:
Dihydrolipoamide dehydrogenase-binding protein; Dihydrolipoamide dehydrogenase-binding protein of pyruvate dehydrogenase complex; Dihyrolipoamide acetyl transferase; Dldbp; E3-binding protein; E3bp; Lipoyl-containing component x; Lipoyl-containing pyruvate dehydrogenase complex component x; Odpx; Opdx; Pdhx; Pdx1; Protein x; Prox; Pyruvate dehydrogenase complex protein x; Pyruvate dehydrogenase protein x component, mitochondrial
Type:
Uncharacterized protein
Mass (Da):
54122
Number AA:
501
UniProt ID:
O00330
International Prot ID:
IPI00298423
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005759
Uniprot
OncoNet
Molecular Function:
GO:0008415
GO:0031405
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0006090
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y16
C
D
P
R
L
L
R
Y
L
V
G
F
P
G
R
Site 2
S25
V
G
F
P
G
R
R
S
V
G
L
V
K
G
A
Site 3
S36
V
K
G
A
L
G
W
S
V
S
R
G
A
N
W
Site 4
S65
K
I
L
M
P
S
L
S
P
T
M
E
E
G
N
Site 5
T101
E
T
D
K
A
V
V
T
L
D
A
S
D
D
G
Site 6
S119
K
I
V
V
E
E
G
S
K
N
I
R
L
G
S
Site 7
S154
V
G
P
P
P
P
V
S
K
P
S
E
P
R
P
Site 8
S157
P
P
P
V
S
K
P
S
E
P
R
P
S
P
E
Site 9
S162
K
P
S
E
P
R
P
S
P
E
P
Q
I
S
I
Site 10
S168
P
S
P
E
P
Q
I
S
I
P
V
K
K
E
H
Site 11
T179
K
K
E
H
I
P
G
T
L
R
F
R
L
S
P
Site 12
S196
R
N
I
L
E
K
H
S
L
D
A
S
Q
G
T
Site 13
S200
E
K
H
S
L
D
A
S
Q
G
T
A
T
G
P
Site 14
T234
K
I
T
E
S
R
P
T
P
A
P
T
A
T
P
Site 15
T238
S
R
P
T
P
A
P
T
A
T
P
T
A
P
S
Site 16
T240
P
T
P
A
P
T
A
T
P
T
A
P
S
P
L
Site 17
S245
T
A
T
P
T
A
P
S
P
L
Q
A
T
A
G
Site 18
T250
A
P
S
P
L
Q
A
T
A
G
P
S
Y
P
R
Site 19
S254
L
Q
A
T
A
G
P
S
Y
P
R
P
V
I
P
Site 20
Y255
Q
A
T
A
G
P
S
Y
P
R
P
V
I
P
P
Site 21
S264
R
P
V
I
P
P
V
S
T
P
G
Q
P
N
A
Site 22
T274
G
Q
P
N
A
V
G
T
F
T
E
I
P
A
S
Site 23
T292
R
V
I
A
K
R
L
T
E
S
K
S
T
V
P
Site 24
S294
I
A
K
R
L
T
E
S
K
S
T
V
P
H
A
Site 25
S296
K
R
L
T
E
S
K
S
T
V
P
H
A
Y
A
Site 26
T297
R
L
T
E
S
K
S
T
V
P
H
A
Y
A
T
Site 27
S392
G
I
Q
E
I
A
D
S
V
K
A
L
S
K
K
Site 28
Y410
G
K
L
L
P
E
E
Y
Q
G
G
S
F
S
I
Site 29
S414
P
E
E
Y
Q
G
G
S
F
S
I
S
N
L
G
Site 30
S416
E
Y
Q
G
G
S
F
S
I
S
N
L
G
M
F
Site 31
T468
L
Q
Q
R
Q
L
I
T
V
T
M
S
S
D
S
Site 32
T470
Q
R
Q
L
I
T
V
T
M
S
S
D
S
R
V
Site 33
S489
L
A
T
R
F
L
K
S
F
K
A
N
L
E
N
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation