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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PDE2A
Full Name:
cGMP-dependent 3',5'-cyclic phosphodiesterase
Alias:
CGMP-dependent 3',5'-cyclic phosphodiesterase; CGS-PDE; Cyclic GMP-stimulated phosphodiesterase; EC 3.1.4.17; PDE2A1; PED2A4; Phosphodiesterase 2A, cGMP-stimulated
Type:
Phosphodiesterase; EC 3.1.4.17; Nucleotide Metabolism - purine
Mass (Da):
105717
Number AA:
941
UniProt ID:
O00408
International Prot ID:
IPI00451132
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0019898
Uniprot
OncoNet
Molecular Function:
GO:0004118
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0007165
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S13
G
H
S
I
L
C
R
S
Q
Q
Y
P
A
A
R
Site 2
Y16
I
L
C
R
S
Q
Q
Y
P
A
A
R
P
A
E
Site 3
S46
P
P
Q
P
C
A
D
S
L
Q
D
A
L
L
S
Site 4
Y82
L
P
R
V
E
T
V
Y
T
Y
L
L
D
G
E
Site 5
T83
P
R
V
E
T
V
Y
T
Y
L
L
D
G
E
S
Site 6
Y84
R
V
E
T
V
Y
T
Y
L
L
D
G
E
S
Q
Site 7
S90
T
Y
L
L
D
G
E
S
Q
L
V
C
E
D
P
Site 8
S113
K
V
R
E
A
I
I
S
Q
K
R
L
G
C
N
Site 9
S125
G
C
N
G
L
G
F
S
D
L
P
G
K
P
L
Site 10
S170
L
V
H
C
G
Q
L
S
D
N
E
E
W
S
L
Site 11
S176
L
S
D
N
E
E
W
S
L
Q
A
V
E
K
H
Site 12
T224
Q
K
G
G
A
A
Y
T
D
R
D
R
K
I
L
Site 13
Y252
L
Q
L
K
V
L
Q
Y
L
Q
Q
E
T
R
A
Site 14
S275
S
E
D
N
L
Q
L
S
C
K
V
I
G
D
K
Site 15
S305
Q
V
V
E
D
K
K
S
I
Q
L
K
D
L
T
Site 16
T312
S
I
Q
L
K
D
L
T
S
E
D
V
Q
Q
L
Site 17
S313
I
Q
L
K
D
L
T
S
E
D
V
Q
Q
L
Q
Site 18
T359
K
L
E
G
D
L
F
T
D
E
D
E
H
V
I
Site 19
T378
H
Y
T
S
T
V
L
T
S
T
L
A
F
Q
K
Site 20
S454
G
G
V
V
D
D
E
S
Y
E
I
R
I
P
A
Site 21
Y455
G
V
V
D
D
E
S
Y
E
I
R
I
P
A
D
Site 22
S494
F
Y
R
G
V
D
D
S
T
G
F
R
T
R
N
Site 23
T495
Y
R
G
V
D
D
S
T
G
F
R
T
R
N
I
Site 24
S530
K
I
N
G
P
W
F
S
K
F
D
E
D
L
A
Site 25
Y554
S
I
A
H
S
L
L
Y
K
K
V
N
E
A
Q
Site 26
Y573
L
A
N
E
M
M
M
Y
H
M
K
V
S
D
D
Site 27
Y582
M
K
V
S
D
D
E
Y
T
K
L
L
H
D
G
Site 28
S602
A
I
D
S
N
F
A
S
F
T
Y
T
P
R
S
Site 29
T604
D
S
N
F
A
S
F
T
Y
T
P
R
S
L
P
Site 30
Y605
S
N
F
A
S
F
T
Y
T
P
R
S
L
P
E
Site 31
T606
N
F
A
S
F
T
Y
T
P
R
S
L
P
E
D
Site 32
S609
S
F
T
Y
T
P
R
S
L
P
E
D
D
T
S
Site 33
T615
R
S
L
P
E
D
D
T
S
M
A
I
L
S
M
Site 34
Y632
D
M
N
F
I
N
N
Y
K
I
D
C
P
T
L
Site 35
Y650
C
L
M
V
K
K
G
Y
R
D
P
P
Y
H
N
Site 36
Y672
S
H
F
C
Y
L
L
Y
K
N
L
E
L
T
N
Site 37
Y680
K
N
L
E
L
T
N
Y
L
E
D
I
E
I
F
Site 38
T703
H
D
L
D
H
R
G
T
N
N
S
F
Q
V
A
Site 39
S706
D
H
R
G
T
N
N
S
F
Q
V
A
S
K
S
Site 40
S724
A
L
Y
S
S
E
G
S
V
M
E
R
H
H
F
Site 41
Y754
D
H
F
S
R
K
D
Y
Q
R
M
L
D
L
M
Site 42
Y788
Q
K
M
A
E
V
G
Y
D
R
N
N
K
Q
H
Site 43
S810
L
M
T
S
C
D
L
S
D
Q
T
K
G
W
K
Site 44
T818
D
Q
T
K
G
W
K
T
T
R
K
I
A
E
L
Site 45
Y827
R
K
I
A
E
L
I
Y
K
E
F
F
S
Q
G
Site 46
S832
L
I
Y
K
E
F
F
S
Q
G
D
L
E
K
A
Site 47
Y854
M
M
D
R
E
K
A
Y
I
P
E
L
Q
I
S
Site 48
Y871
E
H
I
A
M
P
I
Y
K
L
L
Q
D
L
F
Site 49
Y885
F
P
K
A
A
E
L
Y
E
R
V
A
S
N
R
Site 50
S890
E
L
Y
E
R
V
A
S
N
R
E
H
W
T
K
Site 51
T903
T
K
V
S
H
K
F
T
I
R
G
L
P
S
N
Site 52
S909
F
T
I
R
G
L
P
S
N
N
S
L
D
F
L
Site 53
S912
R
G
L
P
S
N
N
S
L
D
F
L
D
E
E
Site 54
Y920
L
D
F
L
D
E
E
Y
E
V
P
D
L
D
G
Site 55
T928
E
V
P
D
L
D
G
T
R
A
P
I
N
G
C
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation