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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
FOXN3
Full Name:
Forkhead box protein N3
Alias:
C14orf116; Checkpoint suppressor 1; CHES1; Forkhead box N3
Type:
Transcription protein
Mass (Da):
53835
Number AA:
490
UniProt ID:
O00409
International Prot ID:
IPI00011681
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0008022
GO:0043565
GO:0003700
PhosphoSite+
KinaseNET
Biological Process:
GO:0000077
GO:0000085
GO:0045892
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S8
M
G
P
V
M
P
P
S
K
K
P
E
S
S
G
Site 2
S13
P
P
S
K
K
P
E
S
S
G
I
S
V
S
S
Site 3
S14
P
S
K
K
P
E
S
S
G
I
S
V
S
S
G
Site 4
S17
K
P
E
S
S
G
I
S
V
S
S
G
L
S
Q
Site 5
S19
E
S
S
G
I
S
V
S
S
G
L
S
Q
C
Y
Site 6
S20
S
S
G
I
S
V
S
S
G
L
S
Q
C
Y
G
Site 7
Y26
S
S
G
L
S
Q
C
Y
G
G
S
G
F
S
K
Site 8
S29
L
S
Q
C
Y
G
G
S
G
F
S
K
A
L
Q
Site 9
S44
E
D
D
D
L
D
F
S
L
P
D
I
R
L
E
Site 10
S75
E
S
K
N
L
L
K
S
F
G
E
S
V
L
R
Site 11
S83
F
G
E
S
V
L
R
S
V
S
P
V
Q
D
L
Site 12
S85
E
S
V
L
R
S
V
S
P
V
Q
D
L
D
D
Site 13
T94
V
Q
D
L
D
D
D
T
P
P
S
P
A
H
S
Site 14
S97
L
D
D
D
T
P
P
S
P
A
H
S
D
M
P
Site 15
S101
T
P
P
S
P
A
H
S
D
M
P
Y
D
A
R
Site 16
Y105
P
A
H
S
D
M
P
Y
D
A
R
Q
N
P
N
Site 17
Y117
N
P
N
C
K
P
P
Y
S
F
S
C
L
I
F
Site 18
T132
M
A
I
E
D
S
P
T
K
R
L
P
V
K
D
Site 19
Y141
R
L
P
V
K
D
I
Y
N
W
I
L
E
H
F
Site 20
S161
A
P
T
G
W
K
N
S
V
R
H
N
L
S
L
Site 21
S167
N
S
V
R
H
N
L
S
L
N
K
C
F
K
K
Site 22
S180
K
K
V
D
K
E
R
S
Q
S
I
G
K
G
S
Site 23
S182
V
D
K
E
R
S
Q
S
I
G
K
G
S
L
W
Site 24
S187
S
Q
S
I
G
K
G
S
L
W
C
I
D
P
E
Site 25
Y195
L
W
C
I
D
P
E
Y
R
Q
N
L
I
Q
A
Site 26
T206
L
I
Q
A
L
K
K
T
P
Y
H
P
H
P
H
Site 27
Y208
Q
A
L
K
K
T
P
Y
H
P
H
P
H
V
F
Site 28
T217
P
H
P
H
V
F
N
T
P
P
T
C
P
Q
A
Site 29
Y225
P
P
T
C
P
Q
A
Y
Q
S
T
S
G
P
P
Site 30
S227
T
C
P
Q
A
Y
Q
S
T
S
G
P
P
I
W
Site 31
S229
P
Q
A
Y
Q
S
T
S
G
P
P
I
W
P
G
Site 32
S237
G
P
P
I
W
P
G
S
T
F
F
K
R
N
G
Site 33
T238
P
P
I
W
P
G
S
T
F
F
K
R
N
G
A
Site 34
S284
Q
N
G
A
R
V
L
S
R
G
L
F
P
G
V
Site 35
T297
G
V
R
P
L
P
I
T
P
I
G
V
T
A
A
Site 36
S311
A
M
R
N
G
I
T
S
C
R
M
R
T
E
S
Site 37
T316
I
T
S
C
R
M
R
T
E
S
E
P
S
C
G
Site 38
S318
S
C
R
M
R
T
E
S
E
P
S
C
G
S
P
Site 39
S321
M
R
T
E
S
E
P
S
C
G
S
P
V
V
S
Site 40
S324
E
S
E
P
S
C
G
S
P
V
V
S
G
D
P
Site 41
S328
S
C
G
S
P
V
V
S
G
D
P
K
E
D
H
Site 42
Y337
D
P
K
E
D
H
N
Y
S
S
A
K
S
S
N
Site 43
S338
P
K
E
D
H
N
Y
S
S
A
K
S
S
N
A
Site 44
S339
K
E
D
H
N
Y
S
S
A
K
S
S
N
A
R
Site 45
S342
H
N
Y
S
S
A
K
S
S
N
A
R
S
T
S
Site 46
S343
N
Y
S
S
A
K
S
S
N
A
R
S
T
S
P
Site 47
S347
A
K
S
S
N
A
R
S
T
S
P
T
S
D
S
Site 48
T348
K
S
S
N
A
R
S
T
S
P
T
S
D
S
I
Site 49
S349
S
S
N
A
R
S
T
S
P
T
S
D
S
I
S
Site 50
T351
N
A
R
S
T
S
P
T
S
D
S
I
S
S
S
Site 51
S352
A
R
S
T
S
P
T
S
D
S
I
S
S
S
S
Site 52
S354
S
T
S
P
T
S
D
S
I
S
S
S
S
S
S
Site 53
S356
S
P
T
S
D
S
I
S
S
S
S
S
S
A
D
Site 54
S357
P
T
S
D
S
I
S
S
S
S
S
S
A
D
D
Site 55
S358
T
S
D
S
I
S
S
S
S
S
S
A
D
D
H
Site 56
S359
S
D
S
I
S
S
S
S
S
S
A
D
D
H
Y
Site 57
S360
D
S
I
S
S
S
S
S
S
A
D
D
H
Y
E
Site 58
S361
S
I
S
S
S
S
S
S
A
D
D
H
Y
E
F
Site 59
Y366
S
S
S
A
D
D
H
Y
E
F
A
T
K
G
S
Site 60
S373
Y
E
F
A
T
K
G
S
Q
E
G
S
E
G
S
Site 61
S377
T
K
G
S
Q
E
G
S
E
G
S
E
G
S
F
Site 62
S380
S
Q
E
G
S
E
G
S
E
G
S
F
R
S
H
Site 63
S383
G
S
E
G
S
E
G
S
F
R
S
H
E
S
P
Site 64
S386
G
S
E
G
S
F
R
S
H
E
S
P
S
D
T
Site 65
S389
G
S
F
R
S
H
E
S
P
S
D
T
E
E
D
Site 66
T393
S
H
E
S
P
S
D
T
E
E
D
D
R
K
H
Site 67
S401
E
E
D
D
R
K
H
S
Q
K
E
P
K
D
S
Site 68
S408
S
Q
K
E
P
K
D
S
L
G
D
S
G
Y
A
Site 69
S412
P
K
D
S
L
G
D
S
G
Y
A
S
Q
H
K
Site 70
Y414
D
S
L
G
D
S
G
Y
A
S
Q
H
K
K
R
Site 71
S416
L
G
D
S
G
Y
A
S
Q
H
K
K
R
Q
H
Site 72
S432
A
K
A
R
K
V
P
S
D
T
L
P
L
K
K
Site 73
T434
A
R
K
V
P
S
D
T
L
P
L
K
K
R
R
Site 74
T442
L
P
L
K
K
R
R
T
E
K
P
P
E
S
D
Site 75
S448
R
T
E
K
P
P
E
S
D
D
E
E
M
K
E
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation