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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
KPNB3
Full Name:
Importin-5
Alias:
IMB3; importin 5; importin beta-3; Karyopherin beta-3; MGC2068; Ran-binding protein 5; RanBP5
Type:
Karyopherin
Mass (Da):
123630
Number AA:
1097
UniProt ID:
O00410
International Prot ID:
IPI00783829
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005643
GO:0005730
Uniprot
OncoNet
Molecular Function:
GO:0005095
GO:0008536
GO:0008565
PhosphoSite+
KinaseNET
Biological Process:
GO:0006607
GO:0044419
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S20
L
L
L
G
N
L
L
S
P
D
N
V
V
R
K
Site 2
Y33
R
K
Q
A
E
E
T
Y
E
N
I
P
G
Q
S
Site 3
T52
L
L
Q
A
I
R
N
T
T
A
A
E
E
A
R
Site 4
T53
L
Q
A
I
R
N
T
T
A
A
E
E
A
R
Q
Site 5
Y78
S
S
A
F
D
E
V
Y
P
A
L
P
S
D
V
Site 6
S141
K
F
L
F
D
S
V
S
S
Q
N
V
G
L
R
Site 7
S142
F
L
F
D
S
V
S
S
Q
N
V
G
L
R
E
Site 8
Y169
F
G
N
Q
Q
Q
H
Y
L
D
V
I
K
R
M
Site 9
S188
M
Q
D
Q
E
H
P
S
I
R
T
L
S
A
R
Site 10
S193
H
P
S
I
R
T
L
S
A
R
A
T
A
A
F
Site 11
Y230
Q
A
V
N
D
S
C
Y
Q
N
D
D
S
V
L
Site 12
S235
S
C
Y
Q
N
D
D
S
V
L
K
S
L
V
E
Site 13
S239
N
D
D
S
V
L
K
S
L
V
E
I
A
D
T
Site 14
T246
S
L
V
E
I
A
D
T
V
P
K
Y
L
R
P
Site 15
Y250
I
A
D
T
V
P
K
Y
L
R
P
H
L
E
A
Site 16
S270
L
K
L
C
G
D
T
S
L
N
N
M
Q
R
Q
Site 17
T304
H
T
N
I
V
A
Q
T
I
P
Q
M
L
A
M
Site 18
S334
L
E
D
D
D
F
D
S
N
A
V
A
G
E
S
Site 19
Y374
L
Q
N
P
D
W
K
Y
R
H
A
G
L
M
A
Site 20
Y417
D
P
H
P
R
V
R
Y
A
A
C
N
A
V
G
Site 21
S476
F
T
E
D
C
P
K
S
L
L
I
P
Y
L
D
Site 22
Y481
P
K
S
L
L
I
P
Y
L
D
N
L
V
K
H
Site 23
S491
N
L
V
K
H
L
H
S
I
M
V
L
K
L
Q
Site 24
Y530
A
E
E
K
F
V
P
Y
Y
D
L
F
M
P
S
Site 25
Y531
E
E
K
F
V
P
Y
Y
D
L
F
M
P
S
L
Site 26
S578
E
K
F
M
Q
D
A
S
D
V
M
Q
L
L
L
Site 27
T587
V
M
Q
L
L
L
K
T
Q
T
D
F
N
D
M
Site 28
T633
V
M
G
P
L
M
K
T
A
S
I
K
P
E
V
Site 29
T645
P
E
V
A
L
L
D
T
Q
D
M
E
N
M
S
Site 30
S652
T
Q
D
M
E
N
M
S
D
D
D
G
W
E
F
Site 31
S667
V
N
L
G
D
Q
Q
S
F
G
I
K
T
A
G
Site 32
Y741
A
R
V
R
G
P
E
Y
L
T
Q
M
W
H
F
Site 33
S767
E
P
D
S
D
V
L
S
E
I
M
H
S
F
A
Site 34
Y820
V
K
R
Q
D
E
D
Y
D
E
Q
V
E
E
S
Site 35
S827
Y
D
E
Q
V
E
E
S
L
Q
D
E
D
D
N
Site 36
Y837
D
E
D
D
N
D
V
Y
I
L
T
K
V
S
D
Site 37
S848
K
V
S
D
I
L
H
S
I
F
S
S
Y
K
E
Site 38
S851
D
I
L
H
S
I
F
S
S
Y
K
E
K
V
L
Site 39
Y853
L
H
S
I
F
S
S
Y
K
E
K
V
L
P
W
Site 40
S896
D
D
V
I
E
H
C
S
P
A
S
F
K
Y
A
Site 41
Y902
C
S
P
A
S
F
K
Y
A
E
Y
F
L
R
P
Site 42
Y905
A
S
F
K
Y
A
E
Y
F
L
R
P
M
L
Q
Site 43
Y913
F
L
R
P
M
L
Q
Y
V
C
D
N
S
P
E
Site 44
S918
L
Q
Y
V
C
D
N
S
P
E
V
R
Q
A
A
Site 45
Y940
A
Q
Y
G
G
D
N
Y
R
P
F
C
T
E
A
Site 46
S998
E
V
L
P
H
W
L
S
W
L
P
L
H
E
D
Site 47
T1012
D
K
E
E
A
V
Q
T
F
N
Y
L
C
D
L
Site 48
S1040
T
N
L
P
K
I
F
S
I
I
A
E
G
E
M
Site 49
S1071
V
V
R
Q
V
Q
T
S
G
G
L
W
T
E
C
Site 50
S1083
T
E
C
I
A
Q
L
S
P
E
Q
Q
A
A
I
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation