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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
POLRMT
Full Name:
DNA-directed RNA polymerase, mitochondrial
Alias:
APOLMT; DNA-directed RNA polymerase, mitochondrial; EC 2.7.7.6; H-mtRPOL; Mitochondrial; MTRNAP; MTRPOL; Polymerase (RNA) mitochondrial (DNA directed); RPOM
Type:
EC 2.7.7.6; Transcription initiation complex; Transferase; Mitochondrial
Mass (Da):
138620
Number AA:
1230
UniProt ID:
O00411
International Prot ID:
IPI00298738
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0042645
Uniprot
OncoNet
Molecular Function:
GO:0003677
GO:0003899
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0006390
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S41
G
V
C
G
P
R
R
S
S
S
A
S
P
Q
E
Site 2
S42
V
C
G
P
R
R
S
S
S
A
S
P
Q
E
Q
Site 3
S43
C
G
P
R
R
S
S
S
A
S
P
Q
E
Q
D
Site 4
S45
P
R
R
S
S
S
A
S
P
Q
E
Q
D
Q
D
Site 5
S77
V
R
Q
L
Q
A
E
S
V
S
E
V
V
V
N
Site 6
S96
A
R
L
P
E
C
G
S
G
D
G
S
L
Q
P
Site 7
S100
E
C
G
S
G
D
G
S
L
Q
P
P
R
K
V
Site 8
T115
Q
M
G
A
K
D
A
T
P
V
P
C
G
R
W
Site 9
T157
S
G
E
F
K
A
L
T
R
R
L
Q
V
E
P
Site 10
S168
Q
V
E
P
R
L
L
S
K
Q
M
A
G
C
L
Site 11
T179
A
G
C
L
E
D
C
T
R
Q
A
P
E
S
P
Site 12
S185
C
T
R
Q
A
P
E
S
P
W
E
E
Q
L
A
Site 13
S203
Q
E
A
P
G
K
L
S
L
D
V
E
Q
A
P
Site 14
S211
L
D
V
E
Q
A
P
S
G
Q
H
S
Q
A
Q
Site 15
S215
Q
A
P
S
G
Q
H
S
Q
A
Q
L
S
G
Q
Site 16
T260
R
Q
K
R
K
L
L
T
L
D
M
Y
N
A
V
Site 17
Y299
L
T
P
D
L
L
S
Y
A
A
A
L
Q
C
M
Site 18
T315
R
Q
D
Q
D
A
G
T
I
E
R
C
L
E
Q
Site 19
S324
E
R
C
L
E
Q
M
S
Q
E
G
L
K
L
Q
Site 20
T346
L
S
E
E
D
R
A
T
V
L
K
A
V
H
K
Site 21
T357
A
V
H
K
V
K
P
T
F
S
L
P
P
Q
L
Site 22
S359
H
K
V
K
P
T
F
S
L
P
P
Q
L
P
P
Site 23
Y378
S
K
L
L
R
D
V
Y
A
K
D
G
R
V
S
Site 24
S385
Y
A
K
D
G
R
V
S
Y
P
K
L
H
L
P
Site 25
Y386
A
K
D
G
R
V
S
Y
P
K
L
H
L
P
L
Site 26
T433
E
V
K
H
A
R
K
T
L
K
T
L
R
D
Q
Site 27
T436
H
A
R
K
T
L
K
T
L
R
D
Q
W
E
K
Site 28
T452
L
C
R
A
L
R
E
T
K
N
R
L
E
R
E
Site 29
Y461
N
R
L
E
R
E
V
Y
E
G
R
F
S
L
Y
Site 30
S496
A
L
P
A
Q
G
E
S
F
T
T
L
A
R
E
Site 31
T499
A
Q
G
E
S
F
T
T
L
A
R
E
L
S
A
Site 32
S505
T
T
L
A
R
E
L
S
A
R
T
F
S
R
H
Site 33
T508
A
R
E
L
S
A
R
T
F
S
R
H
V
V
Q
Site 34
S510
E
L
S
A
R
T
F
S
R
H
V
V
Q
R
Q
Site 35
S520
V
V
Q
R
Q
R
V
S
G
Q
V
Q
A
L
Q
Site 36
Y533
L
Q
N
H
Y
R
K
Y
L
C
L
L
A
S
D
Site 37
Y552
E
P
C
L
P
R
Q
Y
W
E
E
L
G
A
P
Site 38
S592
Q
A
T
Q
M
P
C
S
L
D
K
P
H
R
S
Site 39
S599
S
L
D
K
P
H
R
S
S
R
L
V
P
V
L
Site 40
S600
L
D
K
P
H
R
S
S
R
L
V
P
V
L
Y
Site 41
Y607
S
R
L
V
P
V
L
Y
H
V
Y
S
F
R
N
Site 42
T656
L
C
P
P
L
P
W
T
S
P
H
S
G
A
F
Site 43
S657
C
P
P
L
P
W
T
S
P
H
S
G
A
F
L
Site 44
S666
H
S
G
A
F
L
L
S
P
T
K
L
M
R
T
Site 45
T673
S
P
T
K
L
M
R
T
V
E
G
A
T
Q
H
Site 46
T686
Q
H
Q
E
L
L
E
T
C
P
P
T
A
L
H
Site 47
S736
L
G
V
P
A
P
P
S
E
A
P
Q
P
P
E
Site 48
S749
P
E
A
H
L
P
H
S
A
A
P
A
R
K
A
Site 49
S774
K
V
A
R
E
M
H
S
L
R
A
E
A
L
Y
Site 50
Y781
S
L
R
A
E
A
L
Y
R
L
S
L
A
Q
H
Site 51
S784
A
E
A
L
Y
R
L
S
L
A
Q
H
L
R
D
Site 52
Y807
M
D
F
R
G
R
T
Y
P
C
P
P
H
F
N
Site 53
S874
V
M
D
D
I
L
D
S
A
D
Q
P
L
T
G
Site 54
T880
D
S
A
D
Q
P
L
T
G
R
K
W
W
M
G
Site 55
Y913
R
A
S
D
P
A
A
Y
V
S
H
L
P
V
H
Site 56
S915
S
D
P
A
A
Y
V
S
H
L
P
V
H
Q
D
Site 57
Y931
S
C
N
G
L
Q
H
Y
A
A
L
G
R
D
S
Site 58
S943
R
D
S
V
G
A
A
S
V
N
L
E
P
S
D
Site 59
S949
A
S
V
N
L
E
P
S
D
V
P
Q
D
V
Y
Site 60
Y956
S
D
V
P
Q
D
V
Y
S
G
V
A
A
Q
V
Site 61
T986
Q
V
L
E
G
F
I
T
R
K
V
V
K
Q
T
Site 62
T993
T
R
K
V
V
K
Q
T
V
M
T
V
V
Y
G
Site 63
Y1004
V
V
Y
G
V
T
R
Y
G
G
R
L
Q
I
E
Site 64
S1018
E
K
R
L
R
E
L
S
D
F
P
Q
E
F
V
Site 65
S1045
K
S
L
Q
E
M
F
S
G
T
R
A
I
Q
H
Site 66
T1055
R
A
I
Q
H
W
L
T
E
S
A
R
L
I
S
Site 67
S1062
T
E
S
A
R
L
I
S
H
M
G
S
V
V
E
Site 68
Y1082
G
V
P
V
I
Q
P
Y
R
L
D
S
K
V
K
Site 69
S1086
I
Q
P
Y
R
L
D
S
K
V
K
Q
I
G
G
Site 70
T1099
G
G
G
I
Q
S
I
T
Y
T
H
N
G
D
I
Site 71
Y1100
G
G
I
Q
S
I
T
Y
T
H
N
G
D
I
S
Site 72
T1101
G
I
Q
S
I
T
Y
T
H
N
G
D
I
S
R
Site 73
S1107
Y
T
H
N
G
D
I
S
R
K
P
N
T
R
K
Site 74
S1176
E
Q
F
V
R
L
H
S
E
P
I
L
Q
D
L
Site 75
S1184
E
P
I
L
Q
D
L
S
R
F
L
V
K
R
F
Site 76
S1193
F
L
V
K
R
F
C
S
E
P
Q
K
I
L
E
Site 77
S1202
P
Q
K
I
L
E
A
S
Q
L
K
E
T
L
Q
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation