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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
IGF2BP3
Full Name:
Insulin-like growth factor 2 mRNA-binding protein 3
Alias:
Cancer/testis antigen 98; CT98; IF2B3; IGF II mRNA binding protein 3; IMP-3; Insulin-like growth factor 2 mRNA binding protein 3; Koc1; Putative RNA binding protein KOC
Type:
RNA binding protein
Mass (Da):
63705
Number AA:
579
UniProt ID:
O00425
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005634
GO:0043226
Uniprot
OncoNet
Molecular Function:
GO:0048027
GO:0000166
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0009653
GO:0017148
GO:0042035
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S10
K
L
Y
I
G
N
L
S
E
N
A
A
P
S
D
Site 2
S16
L
S
E
N
A
A
P
S
D
L
E
S
I
F
K
Site 3
S20
A
A
P
S
D
L
E
S
I
F
K
D
A
K
I
Site 4
S30
K
D
A
K
I
P
V
S
G
P
F
L
V
K
T
Site 5
Y39
P
F
L
V
K
T
G
Y
A
F
V
D
C
P
D
Site 6
S73
K
P
I
E
V
E
H
S
V
P
K
R
Q
R
I
Site 7
T115
E
S
C
E
Q
V
N
T
D
S
E
T
A
V
V
Site 8
S117
C
E
Q
V
N
T
D
S
E
T
A
V
V
N
V
Site 9
S179
R
G
L
G
Q
R
G
S
S
R
Q
G
S
P
G
Site 10
S180
G
L
G
Q
R
G
S
S
R
Q
G
S
P
G
S
Site 11
S184
R
G
S
S
R
Q
G
S
P
G
S
V
S
K
Q
Site 12
S187
S
R
Q
G
S
P
G
S
V
S
K
Q
K
P
C
Site 13
S189
Q
G
S
P
G
S
V
S
K
Q
K
P
C
D
L
Site 14
T222
G
A
T
I
R
N
I
T
K
Q
T
Q
S
K
I
Site 15
S243
N
A
G
A
A
E
K
S
I
T
I
L
S
T
P
Site 16
T245
G
A
A
E
K
S
I
T
I
L
S
T
P
E
G
Site 17
S248
E
K
S
I
T
I
L
S
T
P
E
G
T
S
A
Site 18
T249
K
S
I
T
I
L
S
T
P
E
G
T
S
A
A
Site 19
T306
L
K
K
I
E
Q
D
T
D
T
K
I
T
I
S
Site 20
T308
K
I
E
Q
D
T
D
T
K
I
T
I
S
P
L
Site 21
S313
T
D
T
K
I
T
I
S
P
L
Q
E
L
T
L
Site 22
Y321
P
L
Q
E
L
T
L
Y
N
P
E
R
T
I
T
Site 23
T328
Y
N
P
E
R
T
I
T
V
K
G
N
V
E
T
Site 24
S350
I
M
K
K
I
R
E
S
Y
E
N
D
I
A
S
Site 25
Y351
M
K
K
I
R
E
S
Y
E
N
D
I
A
S
M
Site 26
S357
S
Y
E
N
D
I
A
S
M
N
L
Q
A
H
L
Site 27
S380
L
G
L
F
P
P
T
S
G
M
P
P
P
T
S
Site 28
T386
T
S
G
M
P
P
P
T
S
G
P
P
S
A
M
Site 29
S387
S
G
M
P
P
P
T
S
G
P
P
S
A
M
T
Site 30
S391
P
P
T
S
G
P
P
S
A
M
T
P
P
Y
P
Site 31
T394
S
G
P
P
S
A
M
T
P
P
Y
P
Q
F
E
Site 32
Y397
P
S
A
M
T
P
P
Y
P
Q
F
E
Q
S
E
Site 33
S403
P
Y
P
Q
F
E
Q
S
E
T
E
T
V
H
L
Site 34
T405
P
Q
F
E
Q
S
E
T
E
T
V
H
L
F
I
Site 35
T407
F
E
Q
S
E
T
E
T
V
H
L
F
I
P
A
Site 36
S432
G
Q
H
I
K
Q
L
S
R
F
A
G
A
S
I
Site 37
Y471
F
K
A
Q
G
R
I
Y
G
K
I
K
E
E
N
Site 38
S481
I
K
E
E
N
F
V
S
P
K
E
E
V
K
L
Site 39
S496
E
A
H
I
R
V
P
S
F
A
A
G
R
V
I
Site 40
T509
V
I
G
K
G
G
K
T
V
N
E
L
Q
N
L
Site 41
S518
N
E
L
Q
N
L
S
S
A
E
V
V
V
P
R
Site 42
T528
V
V
V
P
R
D
Q
T
P
D
E
N
D
Q
V
Site 43
T558
R
K
I
Q
E
I
L
T
Q
V
K
Q
H
Q
Q
Site 44
S571
Q
Q
Q
K
A
L
Q
S
G
P
P
Q
S
R
R
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation