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Updated November 2019
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Protein Info
Short Name:
PIK3C2A
Full Name:
Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing subunit alpha
Alias:
CPK-M; EC 2.7.1.154; P3C2A; Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing alpha; Phosphoinositide 3-kinase; Phosphoinositide 3-Kinase-C2-alpha; Phosphoinositide-3-kinase, class 2, alpha polypeptide; PI3K C2 alpha; PI3K-C2alpha; PtdIns-3-kinase C2 alpha
Type:
Kinase, lipid; EC 2.7.1.154; Carbohydrate Metabolism - inositol phosphate
Mass (Da):
190680
Number AA:
1686
UniProt ID:
O00443
International Prot ID:
IPI00002580
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005794
GO:0030136
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0016303
GO:0005524
GO:0035005
PhosphoSite+
KinaseNET
Biological Process:
GO:0006661
GO:0046854
GO:0048015
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S5
_
_
_
M
A
Q
I
S
S
N
S
G
F
K
E
Site 2
S6
_
_
M
A
Q
I
S
S
N
S
G
F
K
E
C
Site 3
S8
M
A
Q
I
S
S
N
S
G
F
K
E
C
P
S
Site 4
S15
S
G
F
K
E
C
P
S
S
H
P
E
P
T
R
Site 5
S16
G
F
K
E
C
P
S
S
H
P
E
P
T
R
A
Site 6
T49
L
Q
K
D
R
Q
V
T
D
N
Q
R
G
F
E
Site 7
S58
N
Q
R
G
F
E
L
S
S
S
T
R
K
K
A
Site 8
S59
Q
R
G
F
E
L
S
S
S
T
R
K
K
A
Q
Site 9
S60
R
G
F
E
L
S
S
S
T
R
K
K
A
Q
V
Site 10
Y73
Q
V
Y
N
K
Q
D
Y
D
L
M
V
F
P
E
Site 11
S81
D
L
M
V
F
P
E
S
D
S
Q
K
R
A
L
Site 12
S83
M
V
F
P
E
S
D
S
Q
K
R
A
L
D
I
Site 13
S108
E
K
L
L
L
D
D
S
F
E
T
K
K
T
P
Site 14
T114
D
S
F
E
T
K
K
T
P
V
L
P
V
T
P
Site 15
T120
K
T
P
V
L
P
V
T
P
I
L
S
P
S
F
Site 16
S124
L
P
V
T
P
I
L
S
P
S
F
S
A
Q
L
Site 17
Y132
P
S
F
S
A
Q
L
Y
F
R
P
T
I
Q
R
Site 18
S150
P
P
G
L
P
G
P
S
T
Y
A
L
P
S
I
Site 19
T151
P
G
L
P
G
P
S
T
Y
A
L
P
S
I
Y
Site 20
Y152
G
L
P
G
P
S
T
Y
A
L
P
S
I
Y
P
Site 21
S156
P
S
T
Y
A
L
P
S
I
Y
P
S
T
Y
S
Site 22
Y158
T
Y
A
L
P
S
I
Y
P
S
T
Y
S
K
Q
Site 23
S160
A
L
P
S
I
Y
P
S
T
Y
S
K
Q
A
A
Site 24
T161
L
P
S
I
Y
P
S
T
Y
S
K
Q
A
A
F
Site 25
S163
S
I
Y
P
S
T
Y
S
K
Q
A
A
F
Q
N
Site 26
T178
G
F
N
P
R
M
P
T
F
P
S
T
E
P
I
Site 27
S181
P
R
M
P
T
F
P
S
T
E
P
I
Y
L
S
Site 28
T182
R
M
P
T
F
P
S
T
E
P
I
Y
L
S
L
Site 29
Y186
F
P
S
T
E
P
I
Y
L
S
L
P
G
Q
S
Site 30
S188
S
T
E
P
I
Y
L
S
L
P
G
Q
S
P
Y
Site 31
S193
Y
L
S
L
P
G
Q
S
P
Y
F
S
Y
P
L
Site 32
Y195
S
L
P
G
Q
S
P
Y
F
S
Y
P
L
T
P
Site 33
S197
P
G
Q
S
P
Y
F
S
Y
P
L
T
P
A
T
Site 34
Y198
G
Q
S
P
Y
F
S
Y
P
L
T
P
A
T
P
Site 35
T201
P
Y
F
S
Y
P
L
T
P
A
T
P
F
H
P
Site 36
T204
S
Y
P
L
T
P
A
T
P
F
H
P
Q
G
S
Site 37
Y215
P
Q
G
S
L
P
I
Y
R
P
V
V
S
T
D
Site 38
S232
K
L
F
D
K
I
A
S
T
S
E
F
L
K
N
Site 39
S234
F
D
K
I
A
S
T
S
E
F
L
K
N
G
K
Site 40
T249
A
R
T
D
L
E
I
T
D
S
K
V
S
N
L
Site 41
S251
T
D
L
E
I
T
D
S
K
V
S
N
L
Q
V
Site 42
S254
E
I
T
D
S
K
V
S
N
L
Q
V
S
P
K
Site 43
S259
K
V
S
N
L
Q
V
S
P
K
S
E
D
I
S
Site 44
S262
N
L
Q
V
S
P
K
S
E
D
I
S
K
F
D
Site 45
S266
S
P
K
S
E
D
I
S
K
F
D
W
L
D
L
Site 46
S277
W
L
D
L
D
P
L
S
K
P
K
V
D
N
V
Site 47
S313
A
V
L
L
E
E
R
S
T
A
N
C
H
L
E
Site 48
T314
V
L
L
E
E
R
S
T
A
N
C
H
L
E
R
Site 49
S327
E
R
K
V
N
G
K
S
L
S
V
A
T
V
T
Site 50
S329
K
V
N
G
K
S
L
S
V
A
T
V
T
R
S
Site 51
T332
G
K
S
L
S
V
A
T
V
T
R
S
Q
S
L
Site 52
S336
S
V
A
T
V
T
R
S
Q
S
L
N
I
R
T
Site 53
S338
A
T
V
T
R
S
Q
S
L
N
I
R
T
T
Q
Site 54
T344
Q
S
L
N
I
R
T
T
Q
L
A
K
A
Q
G
Site 55
S354
A
K
A
Q
G
H
I
S
Q
K
D
P
N
G
T
Site 56
S362
Q
K
D
P
N
G
T
S
S
L
P
T
G
S
S
Site 57
S363
K
D
P
N
G
T
S
S
L
P
T
G
S
S
L
Site 58
T366
N
G
T
S
S
L
P
T
G
S
S
L
L
Q
E
Site 59
S369
S
S
L
P
T
G
S
S
L
L
Q
E
V
E
V
Site 60
T389
A
A
F
C
R
S
I
T
K
L
K
T
K
F
P
Site 61
T393
R
S
I
T
K
L
K
T
K
F
P
Y
T
N
H
Site 62
T398
L
K
T
K
F
P
Y
T
N
H
R
T
N
P
G
Site 63
Y406
N
H
R
T
N
P
G
Y
L
L
S
P
V
T
A
Site 64
S409
T
N
P
G
Y
L
L
S
P
V
T
A
Q
R
N
Site 65
S427
E
N
A
S
V
K
V
S
I
D
I
E
G
F
Q
Site 66
T526
R
T
A
E
D
D
E
T
P
V
D
L
N
K
H
Site 67
Y535
V
D
L
N
K
H
L
Y
Q
I
E
K
P
C
K
Site 68
S556
P
V
E
E
L
L
D
S
Y
H
N
Q
V
E
L
Site 69
Y557
V
E
E
L
L
D
S
Y
H
N
Q
V
E
L
A
Site 70
S599
E
T
L
A
I
T
E
S
V
K
K
L
K
R
A
Site 71
S612
R
A
V
N
L
P
R
S
K
T
A
D
V
T
S
Site 72
T614
V
N
L
P
R
S
K
T
A
D
V
T
S
L
F
Site 73
T618
R
S
K
T
A
D
V
T
S
L
F
G
G
E
D
Site 74
S619
S
K
T
A
D
V
T
S
L
F
G
G
E
D
T
Site 75
T626
S
L
F
G
G
E
D
T
S
R
S
S
T
R
G
Site 76
S627
L
F
G
G
E
D
T
S
R
S
S
T
R
G
S
Site 77
S629
G
G
E
D
T
S
R
S
S
T
R
G
S
L
N
Site 78
S630
G
E
D
T
S
R
S
S
T
R
G
S
L
N
P
Site 79
T631
E
D
T
S
R
S
S
T
R
G
S
L
N
P
E
Site 80
S634
S
R
S
S
T
R
G
S
L
N
P
E
N
P
V
Site 81
S662
L
L
R
L
H
A
N
S
G
R
S
P
T
D
C
Site 82
S665
L
H
A
N
S
G
R
S
P
T
D
C
A
Q
S
Site 83
T667
A
N
S
G
R
S
P
T
D
C
A
Q
S
S
K
Site 84
S672
S
P
T
D
C
A
Q
S
S
K
S
V
K
E
A
Site 85
S673
P
T
D
C
A
Q
S
S
K
S
V
K
E
A
W
Site 86
S675
D
C
A
Q
S
S
K
S
V
K
E
A
W
T
T
Site 87
T682
S
V
K
E
A
W
T
T
T
E
Q
L
Q
F
T
Site 88
Y704
S
S
N
W
V
S
N
Y
E
K
Y
Y
L
I
C
Site 89
Y707
W
V
S
N
Y
E
K
Y
Y
L
I
C
S
L
S
Site 90
Y708
V
S
N
Y
E
K
Y
Y
L
I
C
S
L
S
H
Site 91
S712
E
K
Y
Y
L
I
C
S
L
S
H
N
G
K
D
Site 92
Y737
G
T
Y
K
N
F
F
Y
L
I
K
W
D
E
L
Site 93
S771
L
F
G
I
L
N
Q
S
S
G
S
S
P
D
S
Site 94
S772
F
G
I
L
N
Q
S
S
G
S
S
P
D
S
N
Site 95
S774
I
L
N
Q
S
S
G
S
S
P
D
S
N
K
Q
Site 96
S775
L
N
Q
S
S
G
S
S
P
D
S
N
K
Q
R
Site 97
S778
S
S
G
S
S
P
D
S
N
K
Q
R
K
G
P
Site 98
Y810
T
C
G
T
K
L
L
Y
L
W
T
S
S
H
T
Site 99
T813
T
K
L
L
Y
L
W
T
S
S
H
T
N
S
V
Site 100
S814
K
L
L
Y
L
W
T
S
S
H
T
N
S
V
P
Site 101
S815
L
L
Y
L
W
T
S
S
H
T
N
S
V
P
G
Site 102
S819
W
T
S
S
H
T
N
S
V
P
G
T
V
T
K
Site 103
T823
H
T
N
S
V
P
G
T
V
T
K
K
G
Y
V
Site 104
Y849
S
P
A
F
D
I
I
Y
T
T
P
Q
V
D
R
Site 105
S883
L
D
I
L
H
K
D
S
S
L
G
L
S
K
E
Site 106
S884
D
I
L
H
K
D
S
S
L
G
L
S
K
E
D
Site 107
S888
K
D
S
S
L
G
L
S
K
E
D
K
A
F
L
Site 108
Y900
A
F
L
W
E
K
R
Y
Y
C
F
K
H
P
N
Site 109
S929
V
N
L
A
K
T
Y
S
L
L
H
Q
W
P
A
Site 110
Y984
Q
F
V
Q
A
L
K
Y
E
I
Y
L
N
S
S
Site 111
Y987
Q
A
L
K
Y
E
I
Y
L
N
S
S
L
V
Q
Site 112
S1024
A
L
H
D
V
Q
F
S
T
R
Y
E
H
V
L
Site 113
Y1027
D
V
Q
F
S
T
R
Y
E
H
V
L
G
A
L
Site 114
S1067
A
E
K
V
R
Q
A
S
G
S
A
R
Q
V
V
Site 115
S1069
K
V
R
Q
A
S
G
S
A
R
Q
V
V
L
Q
Site 116
S1078
R
Q
V
V
L
Q
R
S
M
E
R
V
Q
S
F
Site 117
S1084
R
S
M
E
R
V
Q
S
F
F
Q
K
N
K
C
Site 118
S1098
C
R
L
P
L
K
P
S
L
V
A
K
E
L
N
Site 119
S1108
A
K
E
L
N
I
K
S
C
S
F
F
S
S
N
Site 120
T1192
E
L
V
P
A
S
D
T
L
R
K
I
Q
V
E
Site 121
Y1200
L
R
K
I
Q
V
E
Y
G
V
T
G
S
F
K
Site 122
T1203
I
Q
V
E
Y
G
V
T
G
S
F
K
D
K
P
Site 123
S1205
V
E
Y
G
V
T
G
S
F
K
D
K
P
L
A
Site 124
Y1218
L
A
E
W
L
R
K
Y
N
P
S
E
E
E
Y
Site 125
S1221
W
L
R
K
Y
N
P
S
E
E
E
Y
E
K
A
Site 126
Y1225
Y
N
P
S
E
E
E
Y
E
K
A
S
E
N
F
Site 127
S1281
G
H
A
Q
M
F
G
S
F
K
R
D
R
A
P
Site 128
S1347
S
G
L
P
E
L
T
S
I
Q
D
L
K
Y
V
Site 129
Y1353
T
S
I
Q
D
L
K
Y
V
R
D
A
L
Q
P
Site 130
S1399
N
L
A
Q
L
R
F
S
G
L
P
S
N
D
E
Site 131
S1403
L
R
F
S
G
L
P
S
N
D
E
P
I
L
S
Site 132
S1410
S
N
D
E
P
I
L
S
F
S
P
K
T
Y
S
Site 133
S1412
D
E
P
I
L
S
F
S
P
K
T
Y
S
F
R
Site 134
T1415
I
L
S
F
S
P
K
T
Y
S
F
R
Q
D
G
Site 135
Y1416
L
S
F
S
P
K
T
Y
S
F
R
Q
D
G
R
Site 136
S1417
S
F
S
P
K
T
Y
S
F
R
Q
D
G
R
I
Site 137
S1428
D
G
R
I
K
E
V
S
V
F
T
Y
H
K
K
Site 138
Y1432
K
E
V
S
V
F
T
Y
H
K
K
Y
N
P
D
Site 139
Y1436
V
F
T
Y
H
K
K
Y
N
P
D
K
H
Y
I
Site 140
Y1442
K
Y
N
P
D
K
H
Y
I
Y
V
V
R
I
L
Site 141
Y1444
N
P
D
K
H
Y
I
Y
V
V
R
I
L
R
E
Site 142
S1457
R
E
G
Q
I
E
P
S
F
V
F
R
T
F
D
Site 143
T1462
E
P
S
F
V
F
R
T
F
D
E
F
Q
E
L
Site 144
S1509
K
R
K
I
E
L
N
S
Y
L
Q
S
L
M
N
Site 145
Y1510
R
K
I
E
L
N
S
Y
L
Q
S
L
M
N
A
Site 146
S1513
E
L
N
S
Y
L
Q
S
L
M
N
A
S
T
D
Site 147
S1546
K
A
E
G
I
A
R
S
A
D
A
G
S
F
S
Site 148
S1551
A
R
S
A
D
A
G
S
F
S
P
T
P
G
Q
Site 149
S1553
S
A
D
A
G
S
F
S
P
T
P
G
Q
I
G
Site 150
T1555
D
A
G
S
F
S
P
T
P
G
Q
I
G
G
A
Site 151
S1566
I
G
G
A
V
K
L
S
I
S
Y
R
N
G
T
Site 152
Y1595
D
G
A
D
P
N
P
Y
V
K
T
Y
L
L
P
Site 153
Y1599
P
N
P
Y
V
K
T
Y
L
L
P
D
N
H
K
Site 154
T1607
L
L
P
D
N
H
K
T
S
K
R
K
T
K
I
Site 155
S1608
L
P
D
N
H
K
T
S
K
R
K
T
K
I
S
Site 156
T1612
H
K
T
S
K
R
K
T
K
I
S
R
K
T
R
Site 157
S1615
S
K
R
K
T
K
I
S
R
K
T
R
N
P
T
Site 158
T1618
K
T
K
I
S
R
K
T
R
N
P
T
F
N
E
Site 159
T1622
S
R
K
T
R
N
P
T
F
N
E
M
L
V
Y
Site 160
Y1629
T
F
N
E
M
L
V
Y
S
G
Y
S
K
E
T
Site 161
S1645
R
Q
R
E
L
Q
L
S
V
L
S
A
E
S
L
Site 162
S1648
E
L
Q
L
S
V
L
S
A
E
S
L
R
E
N
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation