PhosphoNET

           
Protein Info 
   
Short Name:  PLK4
Full Name:  Serine/threonine-protein kinase PLK4
Alias:  EC 2.7.11.21; PLK-4; Polo-like kinase 4; Sak; Serine,threonine-protein kinase 18; Serine/threonine protein kinase Sak; Serine/threonine-protein kinase 18; STK18
Type:  EC 2.7.11.21; Protein kinase, Ser/Thr (non-receptor); Other group; PLK family
Mass (Da):  108972
Number AA:  970
UniProt ID:  O00444
International Prot ID:  IPI00410344
Sequence:  Retrieve full protein sequence
   
GO Terms  External Links Internal Links  
   
Cellular Component:  GO:0005814  GO:0005829  GO:0005730 Uniprot OncoNet
Molecular Function:  GO:0005524  GO:0005515  GO:0004674 PhosphoSite+ KinaseNET
Biological Process:  GO:0046601  GO:0006468  GO:0060707 Phosida TranscriptoNet
    STRING Kinexus Products
   
Info Box  A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites 
-7-6-5-4-3-2-101234567Expt. conf.EffectKinasePPaseKinexus ProductsRef.Evol.Kinase Pred.P-site Match
Site 1S22GNLLGKGSFAGVYRA
Site 2Y27KGSFAGVYRAESIHT
Site 3Y76HPSILELYNYFEDSN
Site 4Y78SILELYNYFEDSNYV
Site 5Y84NYFEDSNYVYLVLEM
Site 6Y100HNGEMNRYLKNRVKP
Site 7S109KNRVKPFSENEARHF
Site 8S140LHRDLTLSNLLLTRN
Site 9T159IADFGLATQLKMPHE
Site 10Y169KMPHEKHYTLCGTPN
Site 11T170MPHEKHYTLCGTPNY
Site 12T174KHYTLCGTPNYISPE
Site 13Y177TLCGTPNYISPEIAT
Site 14S179CGTPNYISPEIATRS
Site 15S186SPEIATRSAHGLESD
Site 16S192RSAHGLESDVWSLGC
Site 17T213IGRPPFDTDTVKNTL
Site 18T215RPPFDTDTVKNTLNK
Site 19S232LADYEMPSFLSIEAK
Site 20S255RNPADRLSLSSVLDH
Site 21S257PADRLSLSSVLDHPF
Site 22S258ADRLSLSSVLDHPFM
Site 23S266VLDHPFMSRNSSTKS
Site 24S269HPFMSRNSSTKSKDL
Site 25S270PFMSRNSSTKSKDLG
Site 26S273SRNSSTKSKDLGTVE
Site 27T278TKSKDLGTVEDSIDS
Site 28S282DLGTVEDSIDSGHAT
Site 29S285TVEDSIDSGHATIST
Site 30T289SIDSGHATISTAITA
Site 31S291DSGHATISTAITASS
Site 32T292SGHATISTAITASSS
Site 33T295ATISTAITASSSTSI
Site 34S297ISTAITASSSTSISG
Site 35S298STAITASSSTSISGS
Site 36T300AITASSSTSISGSLF
Site 37S301ITASSSTSISGSLFD
Site 38S303ASSSTSISGSLFDKR
Site 39S305SSTSISGSLFDKRRL
Site 40T323QPLPNKMTVFPKNKS
Site 41S330TVFPKNKSSTDFSSS
Site 42S331VFPKNKSSTDFSSSG
Site 43T332FPKNKSSTDFSSSGD
Site 44S335NKSSTDFSSSGDGNS
Site 45S336KSSTDFSSSGDGNSF
Site 46S337SSTDFSSSGDGNSFY
Site 47S342SSSGDGNSFYTQWGN
Site 48Y344SGDGNSFYTQWGNQE
Site 49T345GDGNSFYTQWGNQET
Site 50S353QWGNQETSNSGRGRV
Site 51S355GNQETSNSGRGRVIQ
Site 52S370DAEERPHSRYLRRAY
Site 53Y372EERPHSRYLRRAYSS
Site 54Y377SRYLRRAYSSDRSGT
Site 55S378RYLRRAYSSDRSGTS
Site 56S379YLRRAYSSDRSGTSN
Site 57S382RAYSSDRSGTSNSQS
Site 58T384YSSDRSGTSNSQSQA
Site 59S385SSDRSGTSNSQSQAK
Site 60S387DRSGTSNSQSQAKTY
Site 61S389SGTSNSQSQAKTYTM
Site 62T393NSQSQAKTYTMERCH
Site 63Y394SQSQAKTYTMERCHS
Site 64S401YTMERCHSAEMLSVS
Site 65S406CHSAEMLSVSKRSGG
Site 66S408SAEMLSVSKRSGGGE
Site 67Y420GGENEERYSPTDNNA
Site 68S421GENEERYSPTDNNAN
Site 69T437FNFFKEKTSSSSGSF
Site 70S438NFFKEKTSSSSGSFE
Site 71S439FFKEKTSSSSGSFER
Site 72S440FKEKTSSSSGSFERP
Site 73S443KTSSSSGSFERPDNN
Site 74S454PDNNQALSNHLCPGK
Site 75T462NHLCPGKTPFPFADP
Site 76T470PFPFADPTPQTETVQ
Site 77T473FADPTPQTETVQQWF
Site 78T492INAHLRKTTEYDSIS
Site 79T493NAHLRKTTEYDSISP
Site 80Y495HLRKTTEYDSISPNR
Site 81S497RKTTEYDSISPNRDF
Site 82S499TTEYDSISPNRDFQG
Site 83S515PDLQKDTSKNAWTDT
Site 84T522SKNAWTDTKVKKNSD
Site 85S531VKKNSDASDNAHSVK
Site 86Y545KQQNTMKYMTALHSK
Site 87T547QNTMKYMTALHSKPE
Site 88S551KYMTALHSKPEIIQQ
Site 89S564QQECVFGSDPLSEQS
Site 90S568VFGSDPLSEQSKTRG
Site 91S571SDPLSEQSKTRGMEP
Site 92T573PLSEQSKTRGMEPPW
Site 93Y582GMEPPWGYQNRTLRS
Site 94T586PWGYQNRTLRSITSP
Site 95S589YQNRTLRSITSPLVA
Site 96T591NRTLRSITSPLVAHR
Site 97S592RTLRSITSPLVAHRL
Site 98T606LKPIRQKTKKAVVSI
Site 99S612KTKKAVVSILDSEEV
Site 100S629ELVKEYASQEYVKEV
Site 101Y632KEYASQEYVKEVLQI
Site 102T645QISSDGNTITIYYPN
Site 103T647SSDGNTITIYYPNGG
Site 104Y649DGNTITIYYPNGGRG
Site 105Y650GNTITIYYPNGGRGF
Site 106S665PLADRPPSPTDNISR
Site 107T667ADRPPSPTDNISRYS
Site 108S671PSPTDNISRYSFDNL
Site 109Y673PTDNISRYSFDNLPE
Site 110S674TDNISRYSFDNLPEK
Site 111Y682FDNLPEKYWRKYQYA
Site 112Y686PEKYWRKYQYASRFV
Site 113Y688KYWRKYQYASRFVQL
Site 114S698RFVQLVRSKSPKITY
Site 115S700VQLVRSKSPKITYFT
Site 116T704RSKSPKITYFTRYAK
Site 117Y705SKSPKITYFTRYAKC
Site 118S718KCILMENSPGADFEV
Site 119Y728ADFEVWFYDGVKIHK
Site 120T736DGVKIHKTEDFIQVI
Site 121S749VIEKTGKSYTLKSES
Site 122T751EKTGKSYTLKSESEV
Site 123S754GKSYTLKSESEVNSL
Site 124S756SYTLKSESEVNSLKE
Site 125S760KSESEVNSLKEEIKM
Site 126Y768LKEEIKMYMDHANEG
Site 127S784RICLALESIISEEER
Site 128S787LALESIISEEERKTR
Site 129T793ISEEERKTRSAPFFP
Site 130S795EEERKTRSAPFFPII
Site 131S809IIGRKPGSTSSPKAL
Site 132T810IGRKPGSTSSPKALS
Site 133S811GRKPGSTSSPKALSP
Site 134S812RKPGSTSSPKALSPP
Site 135S817TSSPKALSPPPSVDS
Site 136S821KALSPPPSVDSNYPT
Site 137S824SPPPSVDSNYPTRER
Site 138Y826PPSVDSNYPTRERAS
Site 139T828SVDSNYPTRERASFN
Site 140S841FNRMVMHSAASPTQA
Site 141T846MHSAASPTQAPILNP
Site 142T864TNEGLGLTTTASGTD
Site 143T866EGLGLTTTASGTDIS
Site 144S868LGLTTTASGTDISSN
Site 145T870LTTTASGTDISSNSL
Site 146S874ASGTDISSNSLKDCL
Site 147S876GTDISSNSLKDCLPK
Site 148S884LKDCLPKSAQLLKSV
Site 149S915WVQFNDGSQLVVQAG
Site 150S927QAGVSSISYTSPNGQ
Site 151Y928AGVSSISYTSPNGQT
Site 152T929GVSSISYTSPNGQTT
Site 153S930VSSISYTSPNGQTTR
Site 154Y938PNGQTTRYGENEKLP
Site 155Y947ENEKLPDYIKQKLQC
 
Legend 
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available  
Products available
 


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