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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
TRAF5
Full Name:
TNF receptor-associated factor 5
Alias:
RING finger protein 84
Type:
Mass (Da):
64406
Number AA:
557
UniProt ID:
O00463
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S19
C
G
F
I
R
Q
N
S
G
N
S
I
S
L
D
Site 2
S24
Q
N
S
G
N
S
I
S
L
D
F
E
P
S
I
Site 3
S30
I
S
L
D
F
E
P
S
I
E
Y
Q
F
V
E
Site 4
Y43
V
E
R
L
E
E
R
Y
K
C
A
F
C
H
S
Site 5
S90
V
D
K
E
V
I
K
S
Q
E
V
F
K
D
N
Site 6
Y107
K
R
E
V
L
N
L
Y
V
Y
C
S
N
A
P
Site 7
S158
K
D
L
K
E
H
L
S
A
S
C
Q
F
R
K
Site 8
S160
L
K
E
H
L
S
A
S
C
Q
F
R
K
E
K
Site 9
Y170
F
R
K
E
K
C
L
Y
C
K
K
D
V
V
V
Site 10
Y191
E
E
N
L
C
P
E
Y
P
V
F
C
P
N
N
Site 11
S244
N
L
Q
Q
H
E
H
S
A
L
R
E
H
M
R
Site 12
S265
V
Q
L
E
E
Q
I
S
D
L
H
K
S
L
E
Site 13
S270
Q
I
S
D
L
H
K
S
L
E
Q
K
E
S
K
Site 14
S276
K
S
L
E
Q
K
E
S
K
I
Q
Q
L
A
E
Site 15
S304
Q
L
F
G
K
N
G
S
F
L
P
N
I
Q
V
Site 16
S388
N
I
H
K
A
Q
L
S
K
N
E
E
R
F
K
Site 17
Y402
K
L
L
E
G
T
C
Y
N
G
K
L
I
W
K
Site 18
Y413
L
I
W
K
V
T
D
Y
K
M
K
K
R
E
A
Site 19
T425
R
E
A
V
D
G
H
T
V
S
I
F
S
Q
S
Site 20
S430
G
H
T
V
S
I
F
S
Q
S
F
Y
T
S
R
Site 21
S432
T
V
S
I
F
S
Q
S
F
Y
T
S
R
C
G
Site 22
Y434
S
I
F
S
Q
S
F
Y
T
S
R
C
G
Y
R
Site 23
Y440
F
Y
T
S
R
C
G
Y
R
L
C
A
R
A
Y
Site 24
Y447
Y
R
L
C
A
R
A
Y
L
N
G
D
G
S
G
Site 25
S453
A
Y
L
N
G
D
G
S
G
R
G
S
H
L
S
Site 26
S457
G
D
G
S
G
R
G
S
H
L
S
L
Y
F
V
Site 27
Y462
R
G
S
H
L
S
L
Y
F
V
V
M
R
G
E
Site 28
S472
V
M
R
G
E
F
D
S
L
L
Q
W
P
F
R
Site 29
T483
W
P
F
R
Q
R
V
T
L
M
L
L
D
Q
S
Site 30
T498
G
K
K
N
I
M
E
T
F
K
P
D
P
N
S
Site 31
S505
T
F
K
P
D
P
N
S
S
S
F
K
R
P
D
Site 32
S506
F
K
P
D
P
N
S
S
S
F
K
R
P
D
G
Site 33
S507
K
P
D
P
N
S
S
S
F
K
R
P
D
G
E
Site 34
S519
D
G
E
M
N
I
A
S
G
C
P
R
F
V
A
Site 35
S528
C
P
R
F
V
A
H
S
V
L
E
N
A
K
N
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation