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Updated November 2019
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Protein Info
Short Name:
AGRN
Full Name:
Agrin
Alias:
Type:
Mass (Da):
214846
Number AA:
2045
UniProt ID:
O00468
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S84
K
D
L
V
A
R
E
S
L
L
D
G
G
N
K
Site 2
T112
N
Q
V
S
T
G
D
T
R
I
F
F
V
N
P
Site 3
Y123
F
V
N
P
A
P
P
Y
L
W
P
A
H
K
N
Site 4
S137
N
E
L
M
L
N
S
S
L
M
R
I
T
L
R
Site 5
T142
N
S
S
L
M
R
I
T
L
R
N
L
E
E
V
Site 6
T162
D
K
P
G
T
H
F
T
P
V
P
P
T
P
P
Site 7
T167
H
F
T
P
V
P
P
T
P
P
D
A
C
R
G
Site 8
S194
A
E
G
P
G
R
A
S
C
V
C
K
K
S
P
Site 9
S200
A
S
C
V
C
K
K
S
P
C
P
S
V
V
A
Site 10
S204
C
K
K
S
P
C
P
S
V
V
A
P
V
C
G
Site 11
S215
P
V
C
G
S
D
A
S
T
Y
S
N
E
C
E
Site 12
T216
V
C
G
S
D
A
S
T
Y
S
N
E
C
E
L
Site 13
Y217
C
G
S
D
A
S
T
Y
S
N
E
C
E
L
Q
Site 14
S218
G
S
D
A
S
T
Y
S
N
E
C
E
L
Q
R
Site 15
S229
E
L
Q
R
A
Q
C
S
Q
Q
R
R
I
R
L
Site 16
S238
Q
R
R
I
R
L
L
S
R
G
P
C
G
S
R
Site 17
S244
L
S
R
G
P
C
G
S
R
D
P
C
S
N
V
Site 18
T252
R
D
P
C
S
N
V
T
C
S
F
G
S
T
C
Site 19
S254
P
C
S
N
V
T
C
S
F
G
S
T
C
A
R
Site 20
S257
N
V
T
C
S
F
G
S
T
C
A
R
S
A
D
Site 21
T258
V
T
C
S
F
G
S
T
C
A
R
S
A
D
G
Site 22
S262
F
G
S
T
C
A
R
S
A
D
G
L
T
A
S
Site 23
T283
C
R
G
A
P
E
G
T
V
C
G
S
D
G
A
Site 24
S287
P
E
G
T
V
C
G
S
D
G
A
D
Y
P
G
Site 25
Y292
C
G
S
D
G
A
D
Y
P
G
E
C
Q
L
L
Site 26
S328
Q
G
A
L
P
D
P
S
R
S
C
R
V
N
P
Site 27
S330
A
L
P
D
P
S
R
S
C
R
V
N
P
R
T
Site 28
T337
S
C
R
V
N
P
R
T
R
R
P
E
M
L
L
Site 29
S348
E
M
L
L
R
P
E
S
C
P
A
R
Q
A
P
Site 30
Y364
C
G
D
D
G
V
T
Y
E
N
D
C
V
M
G
Site 31
S386
L
L
L
Q
K
V
R
S
G
Q
C
Q
G
R
D
Site 32
S407
R
F
N
A
V
C
L
S
R
R
G
R
P
R
C
Site 33
S415
R
R
G
R
P
R
C
S
C
D
R
V
T
C
D
Site 34
T420
R
C
S
C
D
R
V
T
C
D
G
A
Y
R
P
Site 35
Y425
R
V
T
C
D
G
A
Y
R
P
V
C
A
Q
D
Site 36
Y436
C
A
Q
D
G
R
T
Y
D
S
D
C
W
R
Q
Site 37
S466
G
P
C
D
Q
A
P
S
P
C
L
G
V
Q
C
Site 38
Y498
L
Q
A
C
S
S
L
Y
D
P
V
C
G
S
D
Site 39
S504
L
Y
D
P
V
C
G
S
D
G
V
T
Y
G
S
Site 40
Y509
C
G
S
D
G
V
T
Y
G
S
A
C
E
L
E
Site 41
S511
S
D
G
V
T
Y
G
S
A
C
E
L
E
A
T
Site 42
T518
S
A
C
E
L
E
A
T
A
C
T
L
G
R
E
Site 43
T573
V
C
G
S
D
G
H
T
Y
P
S
E
C
M
L
Site 44
Y574
C
G
S
D
G
H
T
Y
P
S
E
C
M
L
H
Site 45
S634
P
P
G
P
V
C
G
S
D
G
V
T
Y
G
S
Site 46
Y639
C
G
S
D
G
V
T
Y
G
S
A
C
E
L
R
Site 47
S641
S
D
G
V
T
Y
G
S
A
C
E
L
R
E
A
Site 48
S676
C
G
S
G
G
S
G
S
G
E
D
G
D
C
E
Site 49
S715
S
C
Q
S
V
P
G
S
P
V
C
G
S
D
G
Site 50
S720
P
G
S
P
V
C
G
S
D
G
V
T
Y
S
T
Site 51
T724
V
C
G
S
D
G
V
T
Y
S
T
E
C
E
L
Site 52
Y725
C
G
S
D
G
V
T
Y
S
T
E
C
E
L
K
Site 53
S726
G
S
D
G
V
T
Y
S
T
E
C
E
L
K
K
Site 54
S738
L
K
K
A
R
C
E
S
Q
R
G
L
Y
V
A
Site 55
Y743
C
E
S
Q
R
G
L
Y
V
A
A
Q
G
A
C
Site 56
T804
P
H
G
S
Y
G
G
T
C
D
P
A
T
G
Q
Site 57
T809
G
G
T
C
D
P
A
T
G
Q
C
S
C
R
P
Site 58
S813
D
P
A
T
G
Q
C
S
C
R
P
G
V
G
G
Site 59
T845
T
D
G
R
S
G
C
T
P
C
S
C
D
P
Q
Site 60
S848
R
S
G
C
T
P
C
S
C
D
P
Q
G
A
V
Site 61
T900
A
D
A
S
A
P
A
T
C
A
E
M
R
C
E
Site 62
T934
T
C
P
E
A
N
A
T
K
V
C
G
S
D
G
Site 63
S939
N
A
T
K
V
C
G
S
D
G
V
T
Y
G
N
Site 64
T943
V
C
G
S
D
G
V
T
Y
G
N
E
C
Q
L
Site 65
Y944
C
G
S
D
G
V
T
Y
G
N
E
C
Q
L
K
Site 66
T952
G
N
E
C
Q
L
K
T
I
A
C
R
Q
G
L
Site 67
T977
Q
E
A
V
A
P
S
T
H
P
T
S
A
S
V
Site 68
S981
A
P
S
T
H
P
T
S
A
S
V
T
V
T
T
Site 69
S983
S
T
H
P
T
S
A
S
V
T
V
T
T
P
G
Site 70
S1009
G
A
L
P
L
A
P
S
S
T
A
H
S
Q
T
Site 71
S1010
A
L
P
L
A
P
S
S
T
A
H
S
Q
T
T
Site 72
S1014
A
P
S
S
T
A
H
S
Q
T
T
P
P
P
S
Site 73
T1016
S
S
T
A
H
S
Q
T
T
P
P
P
S
S
R
Site 74
T1017
S
T
A
H
S
Q
T
T
P
P
P
S
S
R
P
Site 75
S1021
S
Q
T
T
P
P
P
S
S
R
P
R
T
T
A
Site 76
S1022
Q
T
T
P
P
P
S
S
R
P
R
T
T
A
S
Site 77
T1026
P
P
S
S
R
P
R
T
T
A
S
V
P
R
T
Site 78
T1027
P
S
S
R
P
R
T
T
A
S
V
P
R
T
T
Site 79
S1029
S
R
P
R
T
T
A
S
V
P
R
T
T
V
W
Site 80
S1062
S
A
F
G
E
S
G
S
T
D
G
S
S
D
E
Site 81
T1063
A
F
G
E
S
G
S
T
D
G
S
S
D
E
E
Site 82
S1066
E
S
G
S
T
D
G
S
S
D
E
E
L
S
G
Site 83
S1067
S
G
S
T
D
G
S
S
D
E
E
L
S
G
D
Site 84
S1072
G
S
S
D
E
E
L
S
G
D
Q
E
A
S
G
Site 85
S1078
L
S
G
D
Q
E
A
S
G
G
G
S
G
G
L
Site 86
S1082
Q
E
A
S
G
G
G
S
G
G
L
E
P
L
E
Site 87
S1091
G
L
E
P
L
E
G
S
S
V
A
T
P
G
P
Site 88
T1095
L
E
G
S
S
V
A
T
P
G
P
P
V
E
R
Site 89
S1104
G
P
P
V
E
R
A
S
C
Y
N
S
A
L
G
Site 90
S1108
E
R
A
S
C
Y
N
S
A
L
G
C
C
S
D
Site 91
S1114
N
S
A
L
G
C
C
S
D
G
K
T
P
S
L
Site 92
T1118
G
C
C
S
D
G
K
T
P
S
L
D
A
E
G
Site 93
S1120
C
S
D
G
K
T
P
S
L
D
A
E
G
S
N
Site 94
S1126
P
S
L
D
A
E
G
S
N
C
P
A
T
K
V
Site 95
T1131
E
G
S
N
C
P
A
T
K
V
F
Q
G
V
L
Site 96
T1151
E
G
Q
E
L
F
Y
T
P
E
M
A
D
P
K
Site 97
S1159
P
E
M
A
D
P
K
S
E
L
F
G
E
T
A
Site 98
S1168
L
F
G
E
T
A
R
S
I
E
S
T
L
D
D
Site 99
T1172
T
A
R
S
I
E
S
T
L
D
D
L
F
R
N
Site 100
S1180
L
D
D
L
F
R
N
S
D
V
K
K
D
F
R
Site 101
S1188
D
V
K
K
D
F
R
S
V
R
L
R
D
L
G
Site 102
S1199
R
D
L
G
P
G
K
S
V
R
A
I
V
D
V
Site 103
T1211
V
D
V
H
F
D
P
T
T
A
F
R
A
P
D
Site 104
T1212
D
V
H
F
D
P
T
T
A
F
R
A
P
D
V
Site 105
S1230
L
L
R
Q
I
Q
V
S
R
R
R
S
L
G
V
Site 106
S1234
I
Q
V
S
R
R
R
S
L
G
V
R
R
P
L
Site 107
T1274
A
G
A
T
A
R
A
T
T
A
S
R
L
P
S
Site 108
T1275
G
A
T
A
R
A
T
T
A
S
R
L
P
S
S
Site 109
S1277
T
A
R
A
T
T
A
S
R
L
P
S
S
A
V
Site 110
S1281
T
T
A
S
R
L
P
S
S
A
V
T
P
R
A
Site 111
S1282
T
A
S
R
L
P
S
S
A
V
T
P
R
A
P
Site 112
T1285
R
L
P
S
S
A
V
T
P
R
A
P
H
P
S
Site 113
S1292
T
P
R
A
P
H
P
S
H
T
S
Q
P
V
A
Site 114
S1295
A
P
H
P
S
H
T
S
Q
P
V
A
K
T
T
Site 115
T1302
S
Q
P
V
A
K
T
T
A
A
P
T
T
R
R
Site 116
T1306
A
K
T
T
A
A
P
T
T
R
R
P
P
T
T
Site 117
T1307
K
T
T
A
A
P
T
T
R
R
P
P
T
T
A
Site 118
T1312
P
T
T
R
R
P
P
T
T
A
P
S
R
V
P
Site 119
T1313
T
T
R
R
P
P
T
T
A
P
S
R
V
P
G
Site 120
S1316
R
P
P
T
T
A
P
S
R
V
P
G
R
R
P
Site 121
S1335
Q
P
P
K
P
C
D
S
Q
P
C
F
H
G
G
Site 122
Y1411
E
P
Q
G
L
L
L
Y
N
G
N
A
R
G
K
Site 123
T1436
R
V
Q
L
R
F
D
T
G
S
G
P
A
V
L
Site 124
S1438
Q
L
R
F
D
T
G
S
G
P
A
V
L
T
S
Site 125
T1467
S
R
H
W
R
R
G
T
L
S
V
D
G
E
T
Site 126
S1469
H
W
R
R
G
T
L
S
V
D
G
E
T
P
V
Site 127
T1474
T
L
S
V
D
G
E
T
P
V
L
G
E
S
P
Site 128
S1480
E
T
P
V
L
G
E
S
P
S
G
T
D
G
L
Site 129
S1482
P
V
L
G
E
S
P
S
G
T
D
G
L
N
L
Site 130
T1484
L
G
E
S
P
S
G
T
D
G
L
N
L
D
T
Site 131
T1540
G
I
G
P
G
A
A
T
R
G
S
G
V
G
E
Site 132
S1543
P
G
A
A
T
R
G
S
G
V
G
E
C
G
D
Site 133
S1590
P
T
C
A
D
E
K
S
P
C
Q
P
N
P
C
Site 134
T1622
C
P
L
G
R
E
G
T
F
C
Q
T
A
S
G
Site 135
S1628
G
T
F
C
Q
T
A
S
G
Q
D
G
S
G
P
Site 136
S1633
T
A
S
G
Q
D
G
S
G
P
F
L
A
D
F
Site 137
T1653
L
E
L
R
G
L
H
T
F
A
R
D
L
G
E
Site 138
Y1679
G
P
S
G
L
L
L
Y
N
G
Q
K
T
D
G
Site 139
S1692
D
G
K
G
D
F
V
S
L
A
L
R
D
R
R
Site 140
Y1704
D
R
R
L
E
F
R
Y
D
L
G
K
G
A
A
Site 141
S1715
K
G
A
A
V
I
R
S
R
E
P
V
T
L
G
Site 142
T1725
P
V
T
L
G
A
W
T
R
V
S
L
E
R
N
Site 143
S1728
L
G
A
W
T
R
V
S
L
E
R
N
G
R
K
Site 144
T1755
G
E
S
P
V
P
H
T
V
L
N
L
K
E
P
Site 145
Y1764
L
N
L
K
E
P
L
Y
V
G
G
A
P
D
F
Site 146
T1800
L
G
G
R
Q
L
L
T
P
E
H
V
L
R
Q
Site 147
S1812
L
R
Q
V
D
V
T
S
F
A
G
H
P
C
T
Site 148
T1819
S
F
A
G
H
P
C
T
R
A
S
G
H
P
C
Site 149
S1860
E
K
G
L
V
E
K
S
A
G
D
V
D
T
L
Site 150
T1866
K
S
A
G
D
V
D
T
L
A
F
D
G
R
T
Site 151
Y1877
D
G
R
T
F
V
E
Y
L
N
A
V
T
E
S
Site 152
S1890
E
S
E
K
A
L
Q
S
N
H
F
E
L
S
L
Site 153
S1896
Q
S
N
H
F
E
L
S
L
R
T
E
A
T
Q
Site 154
T1913
V
L
W
S
G
K
A
T
E
R
A
D
Y
V
A
Site 155
S1931
V
D
G
H
L
Q
L
S
Y
N
L
G
S
Q
P
Site 156
Y1932
D
G
H
L
Q
L
S
Y
N
L
G
S
Q
P
V
Site 157
S1936
Q
L
S
Y
N
L
G
S
Q
P
V
V
L
R
S
Site 158
S1943
S
Q
P
V
V
L
R
S
T
V
P
V
N
T
N
Site 159
T1944
Q
P
V
V
L
R
S
T
V
P
V
N
T
N
R
Site 160
S1965
H
R
E
Q
R
E
G
S
L
Q
V
G
N
E
A
Site 161
T1975
V
G
N
E
A
P
V
T
G
S
S
P
L
G
A
Site 162
S1978
E
A
P
V
T
G
S
S
P
L
G
A
T
Q
L
Site 163
T2035
H
L
L
E
D
A
V
T
K
P
E
L
R
P
C
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation