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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
NR5A2
Full Name:
Nuclear receptor subfamily 5 group A member 2
Alias:
Alpha-1-fetoprotein transcription factor;B1-binding factor;CYP7A promoter-binding factor;Hepatocytic transcription factor;Liver receptor homolog 1
Type:
Mass (Da):
61331
Number AA:
541
UniProt ID:
O00482
International Prot ID:
IPI00217284
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0003705
GO:0008289
GO:0010843
PhosphoSite+
KinaseNET
Biological Process:
GO:0009790
GO:0043193
GO:0006350
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T7
_
M
S
S
N
S
D
T
G
D
L
Q
E
S
L
Site 2
S13
D
T
G
D
L
Q
E
S
L
K
H
G
L
T
P
Site 3
T19
E
S
L
K
H
G
L
T
P
I
G
A
G
L
P
Site 4
S31
G
L
P
D
R
H
G
S
P
I
P
A
R
G
R
Site 5
S55
E
A
L
G
L
A
R
S
H
G
E
Q
G
Q
M
Site 6
S77
Q
F
K
M
V
N
Y
S
Y
D
E
D
L
E
E
Site 7
Y78
F
K
M
V
N
Y
S
Y
D
E
D
L
E
E
L
Site 8
Y96
C
G
D
K
V
S
G
Y
H
Y
G
L
L
T
C
Site 9
Y98
D
K
V
S
G
Y
H
Y
G
L
L
T
C
E
S
Site 10
T102
G
Y
H
Y
G
L
L
T
C
E
S
C
K
G
F
Site 11
Y140
T
Q
R
K
R
C
P
Y
C
R
F
Q
K
C
L
Site 12
Y172
R
N
K
F
G
P
M
Y
K
R
D
R
A
L
K
Site 13
T208
Q
A
M
P
S
D
L
T
I
S
S
A
I
Q
N
Site 14
S211
P
S
D
L
T
I
S
S
A
I
Q
N
I
H
S
Site 15
S218
S
A
I
Q
N
I
H
S
A
S
K
G
L
P
L
Site 16
T233
N
H
A
A
L
P
P
T
D
Y
D
R
S
P
F
Site 17
Y235
A
A
L
P
P
T
D
Y
D
R
S
P
F
V
T
Site 18
S238
P
P
T
D
Y
D
R
S
P
F
V
T
S
P
I
Site 19
T242
Y
D
R
S
P
F
V
T
S
P
I
S
M
T
M
Site 20
S243
D
R
S
P
F
V
T
S
P
I
S
M
T
M
P
Site 21
Y258
P
H
G
S
L
Q
G
Y
Q
T
Y
G
H
F
P
Site 22
T260
G
S
L
Q
G
Y
Q
T
Y
G
H
F
P
S
R
Site 23
S266
Q
T
Y
G
H
F
P
S
R
A
I
K
S
E
Y
Site 24
S271
F
P
S
R
A
I
K
S
E
Y
P
D
P
Y
T
Site 25
Y273
S
R
A
I
K
S
E
Y
P
D
P
Y
T
S
S
Site 26
Y277
K
S
E
Y
P
D
P
Y
T
S
S
P
E
S
I
Site 27
T278
S
E
Y
P
D
P
Y
T
S
S
P
E
S
I
M
Site 28
S279
E
Y
P
D
P
Y
T
S
S
P
E
S
I
M
G
Site 29
S280
Y
P
D
P
Y
T
S
S
P
E
S
I
M
G
Y
Site 30
S283
P
Y
T
S
S
P
E
S
I
M
G
Y
S
Y
M
Site 31
Y287
S
P
E
S
I
M
G
Y
S
Y
M
D
S
Y
Q
Site 32
Y289
E
S
I
M
G
Y
S
Y
M
D
S
Y
Q
T
S
Site 33
S292
M
G
Y
S
Y
M
D
S
Y
Q
T
S
S
P
A
Site 34
Y293
G
Y
S
Y
M
D
S
Y
Q
T
S
S
P
A
S
Site 35
T295
S
Y
M
D
S
Y
Q
T
S
S
P
A
S
I
P
Site 36
S296
Y
M
D
S
Y
Q
T
S
S
P
A
S
I
P
H
Site 37
S297
M
D
S
Y
Q
T
S
S
P
A
S
I
P
H
L
Site 38
S300
Y
Q
T
S
S
P
A
S
I
P
H
L
I
L
E
Site 39
S340
R
S
K
H
E
K
L
S
T
F
G
L
M
C
K
Site 40
T341
S
K
H
E
K
L
S
T
F
G
L
M
C
K
M
Site 41
S363
I
V
E
W
A
R
S
S
I
F
F
R
E
L
K
Site 42
S383
K
L
L
Q
N
C
W
S
E
L
L
I
L
D
H
Site 43
S414
T
G
Q
Q
V
D
Y
S
I
I
A
S
Q
A
G
Site 44
Y489
L
D
Y
T
M
C
N
Y
P
Q
Q
T
E
K
F
Site 45
S510
L
P
E
I
R
A
I
S
M
Q
A
E
E
Y
L
Site 46
Y516
I
S
M
Q
A
E
E
Y
L
Y
Y
K
H
L
N
Site 47
Y518
M
Q
A
E
E
Y
L
Y
Y
K
H
L
N
G
D
Site 48
Y519
Q
A
E
E
Y
L
Y
Y
K
H
L
N
G
D
V
Site 49
Y528
H
L
N
G
D
V
P
Y
N
N
L
L
I
E
M
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation