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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
BIN1
Full Name:
Myc box-dependent-interacting protein 1
Alias:
AMPH2; Amphiphysin II; Amphiphysin-like protein; AMPHL; Box-dependent myc- interacting protein-1; Box-dependent myc-interacting protein 1; Bridging integrator 1; Myc box dependent interacting protein 1; SH3P9
Type:
Adaptor/scaffold
Mass (Da):
64699
Number AA:
593
UniProt ID:
O00499
International Prot ID:
IPI00186966
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0015629
GO:0005737
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0005488
GO:0005515
GO:0005488
PhosphoSite+
KinaseNET
Biological Process:
GO:0008283
GO:0044419
GO:0007275
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T10
E
M
G
S
K
G
V
T
A
G
K
I
A
S
N
Site 2
S16
V
T
A
G
K
I
A
S
N
V
Q
K
K
L
T
Site 3
T56
Q
N
F
N
K
Q
L
T
E
G
T
R
L
Q
K
Site 4
T67
R
L
Q
K
D
L
R
T
Y
L
A
S
V
K
A
Site 5
Y68
L
Q
K
D
L
R
T
Y
L
A
S
V
K
A
M
Site 6
S71
D
L
R
T
Y
L
A
S
V
K
A
M
H
E
A
Site 7
S79
V
K
A
M
H
E
A
S
K
K
L
N
E
C
L
Site 8
Y90
N
E
C
L
Q
E
V
Y
E
P
D
W
P
G
R
Site 9
Y114
N
D
L
L
W
M
D
Y
H
Q
K
L
V
D
Q
Site 10
T128
Q
A
L
L
T
M
D
T
Y
L
G
Q
F
P
D
Site 11
S138
G
Q
F
P
D
I
K
S
R
I
A
K
R
G
R
Site 12
Y150
R
G
R
K
L
V
D
Y
D
S
A
R
H
H
Y
Site 13
S152
R
K
L
V
D
Y
D
S
A
R
H
H
Y
E
S
Site 14
Y157
Y
D
S
A
R
H
H
Y
E
S
L
Q
T
A
K
Site 15
S159
S
A
R
H
H
Y
E
S
L
Q
T
A
K
K
K
Site 16
S229
D
L
Q
E
E
L
P
S
L
W
N
S
R
V
G
Site 17
S233
E
L
P
S
L
W
N
S
R
V
G
F
Y
V
N
Site 18
Y238
W
N
S
R
V
G
F
Y
V
N
T
F
Q
S
I
Site 19
T278
E
K
Q
H
G
S
N
T
F
T
V
K
A
Q
P
Site 20
T280
Q
H
G
S
N
T
F
T
V
K
A
Q
P
S
D
Site 21
S286
F
T
V
K
A
Q
P
S
D
N
A
P
A
K
G
Site 22
S296
A
P
A
K
G
N
K
S
P
S
P
P
D
G
S
Site 23
S298
A
K
G
N
K
S
P
S
P
P
D
G
S
P
A
Site 24
S303
S
P
S
P
P
D
G
S
P
A
A
T
P
E
I
Site 25
T307
P
D
G
S
P
A
A
T
P
E
I
R
V
N
H
Site 26
T323
P
E
P
A
G
G
A
T
P
G
A
T
L
P
K
Site 27
T327
G
G
A
T
P
G
A
T
L
P
K
S
P
S
Q
Site 28
S331
P
G
A
T
L
P
K
S
P
S
Q
L
R
K
G
Site 29
S333
A
T
L
P
K
S
P
S
Q
L
R
K
G
P
P
Site 30
T348
V
P
P
P
P
K
H
T
P
S
K
E
V
K
Q
Site 31
S350
P
P
P
K
H
T
P
S
K
E
V
K
Q
E
Q
Site 32
S371
D
T
F
V
P
E
I
S
V
T
T
P
S
Q
F
Site 33
T374
V
P
E
I
S
V
T
T
P
S
Q
F
E
A
P
Site 34
S376
E
I
S
V
T
T
P
S
Q
F
E
A
P
G
P
Site 35
S385
F
E
A
P
G
P
F
S
E
Q
A
S
L
L
D
Site 36
S389
G
P
F
S
E
Q
A
S
L
L
D
L
D
F
D
Site 37
S403
D
P
L
P
P
V
T
S
P
V
K
A
P
T
P
Site 38
T409
T
S
P
V
K
A
P
T
P
S
G
Q
S
I
P
Site 39
S411
P
V
K
A
P
T
P
S
G
Q
S
I
P
W
D
Site 40
T423
P
W
D
L
W
E
P
T
E
S
P
A
G
S
L
Site 41
S425
D
L
W
E
P
T
E
S
P
A
G
S
L
P
S
Site 42
S429
P
T
E
S
P
A
G
S
L
P
S
G
E
P
S
Site 43
S432
S
P
A
G
S
L
P
S
G
E
P
S
A
A
E
Site 44
S436
S
L
P
S
G
E
P
S
A
A
E
G
T
F
A
Site 45
T441
E
P
S
A
A
E
G
T
F
A
V
S
W
P
S
Site 46
S448
T
F
A
V
S
W
P
S
Q
T
A
E
P
G
P
Site 47
T450
A
V
S
W
P
S
Q
T
A
E
P
G
P
A
Q
Site 48
S462
P
A
Q
P
A
E
A
S
E
V
A
G
G
T
Q
Site 49
T480
G
A
Q
E
P
G
E
T
A
A
S
E
A
A
S
Site 50
S483
E
P
G
E
T
A
A
S
E
A
A
S
S
S
L
Site 51
S510
N
G
T
V
E
G
G
S
G
A
G
R
L
D
L
Site 52
Y531
K
V
Q
A
Q
H
D
Y
T
A
T
D
T
D
E
Site 53
T532
V
Q
A
Q
H
D
Y
T
A
T
D
T
D
E
L
Site 54
T536
H
D
Y
T
A
T
D
T
D
E
L
Q
L
K
A
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation