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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
USP9Y
Full Name:
Probable ubiquitin carboxyl-terminal hydrolase FAF-Y
Alias:
AZF; AZFA; Deubiquitinating enzyme FAF-Y; DFFRY; Fat facets protein-related, Y- linked; Fat facets protein-related, Y-linked; Fat facets-like; SP3; Ubiquitin carboxyl-terminal hydrolase FAF-Y; Ubiquitin specific peptidase 9, Y-linked; Ubiquitin thioesterase FAF-Y; Ubiquitin-specific protease 9; Ubiquitin-specific protease 9, Y chromosome; Ubiquitin-specific-processing protease FAF-Y; USP10
Type:
Ubiquitin conjugating system; EC 3.1.2.15; Protease
Mass (Da):
291077
Number AA:
2555
UniProt ID:
O00507
International Prot ID:
IPI00012094
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
Uniprot
OncoNet
Molecular Function:
GO:0070410
GO:0004221
GO:0004843
PhosphoSite+
KinaseNET
Biological Process:
GO:0030509
GO:0016579
GO:0007283
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S8
M
T
A
I
T
H
G
S
P
V
G
G
N
D
S
Site 2
S15
S
P
V
G
G
N
D
S
Q
G
Q
V
L
D
G
Site 3
S24
G
Q
V
L
D
G
Q
S
Q
H
L
F
Q
Q
N
Site 4
S34
L
F
Q
Q
N
Q
T
S
S
P
D
S
S
N
E
Site 5
S35
F
Q
Q
N
Q
T
S
S
P
D
S
S
N
E
N
Site 6
S38
N
Q
T
S
S
P
D
S
S
N
E
N
S
V
A
Site 7
S39
Q
T
S
S
P
D
S
S
N
E
N
S
V
A
T
Site 8
S43
P
D
S
S
N
E
N
S
V
A
T
P
P
P
E
Site 9
T46
S
N
E
N
S
V
A
T
P
P
P
E
E
Q
G
Site 10
S114
V
K
G
L
D
V
K
S
E
A
C
Q
R
F
F
Site 11
S199
R
P
C
E
L
I
S
S
N
A
Q
L
P
E
D
Site 12
S212
E
D
E
L
F
A
R
S
S
D
P
R
S
P
K
Site 13
S213
D
E
L
F
A
R
S
S
D
P
R
S
P
K
G
Site 14
S217
A
R
S
S
D
P
R
S
P
K
G
W
L
V
D
Site 15
Y264
I
K
P
F
G
Q
C
Y
E
F
L
S
Q
H
T
Site 16
S309
E
A
K
N
D
A
L
S
M
I
I
K
S
L
K
Site 17
S314
A
L
S
M
I
I
K
S
L
K
N
L
A
S
R
Site 18
S320
K
S
L
K
N
L
A
S
R
I
S
G
Q
D
E
Site 19
S323
K
N
L
A
S
R
I
S
G
Q
D
E
T
I
K
Site 20
T328
R
I
S
G
Q
D
E
T
I
K
N
L
E
I
F
Site 21
S348
L
R
L
L
Q
I
S
S
F
N
G
K
M
N
A
Site 22
S365
E
I
N
K
V
I
S
S
V
S
Y
Y
T
H
R
Site 23
S367
N
K
V
I
S
S
V
S
Y
Y
T
H
R
H
S
Site 24
Y368
K
V
I
S
S
V
S
Y
Y
T
H
R
H
S
N
Site 25
Y369
V
I
S
S
V
S
Y
Y
T
H
R
H
S
N
P
Site 26
T370
I
S
S
V
S
Y
Y
T
H
R
H
S
N
P
E
Site 27
S374
S
Y
Y
T
H
R
H
S
N
P
E
E
E
E
W
Site 28
T383
P
E
E
E
E
W
L
T
A
E
R
M
A
E
W
Site 29
Y410
D
S
L
H
Q
P
Q
Y
V
E
K
L
E
K
I
Site 30
T428
V
I
K
E
K
A
L
T
L
Q
D
L
D
N
I
Site 31
S462
A
K
L
A
W
D
F
S
P
G
Q
L
D
H
L
Site 32
Y539
A
H
I
K
I
L
D
Y
S
C
S
Q
D
R
D
Site 33
S542
K
I
L
D
Y
S
C
S
Q
D
R
D
A
Q
K
Site 34
T562
H
F
I
E
E
L
R
T
N
D
K
W
V
I
P
Site 35
S579
K
Q
I
R
E
I
C
S
L
F
G
E
A
S
Q
Site 36
S585
C
S
L
F
G
E
A
S
Q
N
L
S
Q
T
Q
Site 37
S589
G
E
A
S
Q
N
L
S
Q
T
Q
R
S
P
H
Site 38
T591
A
S
Q
N
L
S
Q
T
Q
R
S
P
H
I
F
Site 39
S594
N
L
S
Q
T
Q
R
S
P
H
I
F
Y
R
H
Site 40
S627
N
L
A
T
Y
M
N
S
I
R
L
Y
A
G
D
Site 41
Y631
Y
M
N
S
I
R
L
Y
A
G
D
H
E
D
Y
Site 42
Y638
Y
A
G
D
H
E
D
Y
D
P
Q
T
V
R
L
Site 43
T642
H
E
D
Y
D
P
Q
T
V
R
L
G
S
R
Y
Site 44
S647
P
Q
T
V
R
L
G
S
R
Y
S
H
V
Q
E
Site 45
Y649
T
V
R
L
G
S
R
Y
S
H
V
Q
E
V
Q
Site 46
S650
V
R
L
G
S
R
Y
S
H
V
Q
E
V
Q
E
Site 47
Y702
R
E
A
C
F
K
W
Y
S
K
L
M
G
D
E
Site 48
S703
E
A
C
F
K
W
Y
S
K
L
M
G
D
E
P
Site 49
S731
N
V
L
Q
L
D
P
S
L
L
T
E
N
G
M
Site 50
S761
K
L
I
A
K
R
R
S
Y
M
M
D
D
L
E
Site 51
Y762
L
I
A
K
R
R
S
Y
M
M
D
D
L
E
L
Site 52
S782
L
W
R
V
V
I
Q
S
S
D
E
I
A
N
R
Site 53
Y798
I
D
L
L
K
E
I
Y
T
N
L
G
P
R
L
Site 54
Y828
F
D
R
L
K
A
S
Y
D
T
L
C
V
F
D
Site 55
T830
R
L
K
A
S
Y
D
T
L
C
V
F
D
G
D
Site 56
Y869
I
N
E
C
D
S
D
Y
H
K
E
R
M
I
L
Site 57
S879
E
R
M
I
L
P
M
S
R
A
F
R
G
K
H
Site 58
S888
A
F
R
G
K
H
L
S
L
I
V
R
F
P
N
Site 59
S944
V
G
G
E
L
I
D
S
E
D
D
R
K
L
I
Site 60
S960
Q
L
N
L
K
D
K
S
L
I
T
A
K
L
T
Site 61
S975
Q
I
N
F
N
M
P
S
S
P
D
S
S
S
D
Site 62
S976
I
N
F
N
M
P
S
S
P
D
S
S
S
D
S
Site 63
S979
N
M
P
S
S
P
D
S
S
S
D
S
S
T
A
Site 64
S980
M
P
S
S
P
D
S
S
S
D
S
S
T
A
S
Site 65
S981
P
S
S
P
D
S
S
S
D
S
S
T
A
S
P
Site 66
S983
S
P
D
S
S
S
D
S
S
T
A
S
P
G
N
Site 67
S984
P
D
S
S
S
D
S
S
T
A
S
P
G
N
H
Site 68
T985
D
S
S
S
D
S
S
T
A
S
P
G
N
H
R
Site 69
S987
S
S
D
S
S
T
A
S
P
G
N
H
R
N
H
Site 70
Y995
P
G
N
H
R
N
H
Y
N
D
G
P
N
L
E
Site 71
S1020
S
V
H
P
R
Y
I
S
F
L
W
Q
V
A
D
Site 72
S1030
W
Q
V
A
D
L
G
S
N
L
N
M
P
P
L
Site 73
S1074
K
L
G
E
G
K
L
S
P
P
L
D
S
L
F
Site 74
T1108
M
P
A
G
V
P
L
T
D
G
S
S
D
F
Q
Site 75
S1111
G
V
P
L
T
D
G
S
S
D
F
Q
V
H
F
Site 76
T1140
R
N
N
F
L
P
N
T
D
M
E
T
R
R
G
Site 77
T1144
L
P
N
T
D
M
E
T
R
R
G
A
Y
L
N
Site 78
Y1149
M
E
T
R
R
G
A
Y
L
N
A
L
K
I
A
Site 79
T1182
C
Q
P
V
V
D
G
T
D
P
I
T
Q
I
N
Site 80
T1186
V
D
G
T
D
P
I
T
Q
I
N
Q
V
T
H
Site 81
S1205
V
L
Q
S
A
L
Q
S
I
P
N
P
S
S
E
Site 82
S1211
Q
S
I
P
N
P
S
S
E
C
V
L
R
N
E
Site 83
S1219
E
C
V
L
R
N
E
S
I
L
L
A
Q
E
I
Site 84
S1227
I
L
L
A
Q
E
I
S
N
E
A
S
R
Y
M
Site 85
S1231
Q
E
I
S
N
E
A
S
R
Y
M
P
D
I
C
Site 86
Y1233
I
S
N
E
A
S
R
Y
M
P
D
I
C
V
I
Site 87
S1309
P
T
A
L
D
A
L
S
K
E
K
A
W
Q
T
Site 88
T1329
L
L
H
C
P
S
K
T
V
R
Q
L
A
Q
E
Site 89
T1361
F
F
I
T
L
L
F
T
I
L
G
S
T
A
R
Site 90
T1366
L
F
T
I
L
G
S
T
A
R
E
K
G
K
Y
Site 91
Y1373
T
A
R
E
K
G
K
Y
S
G
D
Y
F
T
L
Site 92
S1374
A
R
E
K
G
K
Y
S
G
D
Y
F
T
L
L
Site 93
Y1377
K
G
K
Y
S
G
D
Y
F
T
L
L
R
H
L
Site 94
T1379
K
Y
S
G
D
Y
F
T
L
L
R
H
L
L
N
Site 95
Y1387
L
L
R
H
L
L
N
Y
A
Y
N
G
N
I
N
Site 96
Y1389
R
H
L
L
N
Y
A
Y
N
G
N
I
N
I
P
Site 97
T1444
K
E
L
L
A
F
Q
T
S
E
K
K
Y
H
F
Site 98
S1445
E
L
L
A
F
Q
T
S
E
K
K
Y
H
F
G
Site 99
Y1449
F
Q
T
S
E
K
K
Y
H
F
G
C
E
K
G
Site 100
Y1479
A
S
K
V
Y
L
Q
Y
L
R
S
G
E
L
P
Site 101
S1482
V
Y
L
Q
Y
L
R
S
G
E
L
P
A
E
Q
Site 102
Y1546
E
A
L
T
E
W
E
Y
L
P
P
V
G
P
R
Site 103
Y1569
K
N
A
G
A
T
C
Y
M
N
S
V
I
Q
Q
Site 104
Y1578
N
S
V
I
Q
Q
L
Y
M
I
P
S
I
R
N
Site 105
T1593
S
I
L
A
I
E
G
T
G
S
D
L
H
D
D
Site 106
S1595
L
A
I
E
G
T
G
S
D
L
H
D
D
M
F
Site 107
S1609
F
G
D
E
K
Q
D
S
E
S
N
V
D
P
R
Site 108
S1611
D
E
K
Q
D
S
E
S
N
V
D
P
R
D
D
Site 109
Y1622
P
R
D
D
V
F
G
Y
P
H
Q
F
E
D
K
Site 110
T1635
D
K
P
A
L
S
K
T
E
D
R
K
E
Y
N
Site 111
Y1641
K
T
E
D
R
K
E
Y
N
I
G
V
L
R
H
Site 112
Y1663
L
A
A
S
Q
L
Q
Y
Y
V
P
R
G
F
W
Site 113
Y1664
A
A
S
Q
L
Q
Y
Y
V
P
R
G
F
W
K
Site 114
S1694
D
A
L
E
F
F
N
S
L
V
D
S
L
D
E
Site 115
T1740
Y
E
C
E
E
S
F
T
T
L
N
V
D
I
R
Site 116
T1741
E
C
E
E
S
F
T
T
L
N
V
D
I
R
N
Site 117
S1755
N
H
Q
N
L
L
D
S
L
E
Q
Y
I
K
G
Site 118
Y1759
L
L
D
S
L
E
Q
Y
I
K
G
D
L
L
E
Site 119
T1782
K
C
D
K
K
V
D
T
V
K
R
L
L
I
K
Site 120
Y1804
I
Q
L
K
R
F
D
Y
D
W
E
R
E
C
A
Site 121
Y1817
C
A
I
K
F
N
D
Y
F
E
F
P
R
E
L
Site 122
Y1829
R
E
L
D
M
G
P
Y
T
V
A
G
V
A
N
Site 123
T1830
E
L
D
M
G
P
Y
T
V
A
G
V
A
N
L
Site 124
S1844
L
E
R
D
N
V
N
S
E
N
E
L
I
E
Q
Site 125
S1855
L
I
E
Q
K
E
Q
S
D
N
E
T
A
G
G
Site 126
T1859
K
E
Q
S
D
N
E
T
A
G
G
T
K
Y
R
Site 127
S1878
L
V
H
S
G
Q
A
S
G
G
H
Y
Y
S
Y
Site 128
Y1882
G
Q
A
S
G
G
H
Y
Y
S
Y
I
I
Q
R
Site 129
Y1885
S
G
G
H
Y
Y
S
Y
I
I
Q
R
N
G
K
Site 130
Y1900
D
D
Q
T
D
H
W
Y
K
F
D
D
G
D
V
Site 131
T1908
K
F
D
D
G
D
V
T
E
C
K
M
D
D
D
Site 132
Y1970
E
D
D
E
M
I
R
Y
I
S
E
L
T
I
A
Site 133
S1972
D
E
M
I
R
Y
I
S
E
L
T
I
A
R
P
Site 134
S1985
R
P
H
Q
I
I
M
S
P
A
I
E
R
S
V
Site 135
S1991
M
S
P
A
I
E
R
S
V
R
K
Q
N
V
K
Site 136
Y2006
F
M
H
N
R
L
Q
Y
S
L
E
Y
F
Q
F
Site 137
Y2010
R
L
Q
Y
S
L
E
Y
F
Q
F
V
K
K
L
Site 138
Y2033
N
P
A
P
G
Q
D
Y
L
L
P
E
A
E
E
Site 139
S2102
F
N
V
S
N
R
F
S
E
Y
L
L
E
C
P
Site 140
Y2104
V
S
N
R
F
S
E
Y
L
L
E
C
P
S
A
Site 141
S2133
H
F
S
L
Q
D
G
S
C
P
S
P
F
A
S
Site 142
S2136
L
Q
D
G
S
C
P
S
P
F
A
S
P
G
P
Site 143
S2140
S
C
P
S
P
F
A
S
P
G
P
S
S
Q
A
Site 144
S2144
P
F
A
S
P
G
P
S
S
Q
A
C
D
N
L
Site 145
S2145
F
A
S
P
G
P
S
S
Q
A
C
D
N
L
S
Site 146
S2152
S
Q
A
C
D
N
L
S
L
S
D
H
L
L
R
Site 147
S2154
A
C
D
N
L
S
L
S
D
H
L
L
R
A
T
Site 148
T2161
S
D
H
L
L
R
A
T
L
N
L
L
R
R
E
Site 149
S2170
N
L
L
R
R
E
V
S
E
H
G
H
H
L
Q
Site 150
Y2221
G
P
G
P
P
I
K
Y
Q
Y
A
E
L
G
K
Site 151
Y2223
G
P
P
I
K
Y
Q
Y
A
E
L
G
K
L
Y
Site 152
T2245
R
C
C
N
V
S
S
T
M
Q
S
S
I
N
G
Site 153
S2248
N
V
S
S
T
M
Q
S
S
I
N
G
N
P
P
Site 154
S2249
V
S
S
T
M
Q
S
S
I
N
G
N
P
P
L
Site 155
S2266
P
F
G
D
L
N
L
S
Q
P
I
M
P
I
Q
Site 156
S2295
K
K
I
I
E
D
C
S
N
S
E
D
T
I
K
Site 157
S2297
I
I
E
D
C
S
N
S
E
D
T
I
K
L
L
Site 158
S2308
I
K
L
L
R
F
C
S
W
E
N
P
Q
F
S
Site 159
S2315
S
W
E
N
P
Q
F
S
S
T
V
L
S
E
L
Site 160
S2316
W
E
N
P
Q
F
S
S
T
V
L
S
E
L
L
Site 161
T2317
E
N
P
Q
F
S
S
T
V
L
S
E
L
L
W
Site 162
T2373
D
R
D
G
L
F
D
T
I
Q
R
S
K
N
H
Site 163
Y2381
I
Q
R
S
K
N
H
Y
Q
K
R
A
Y
Q
C
Site 164
Y2432
D
E
L
E
R
R
P
Y
T
G
N
P
Q
Y
S
Site 165
T2433
E
L
E
R
R
P
Y
T
G
N
P
Q
Y
S
Y
Site 166
Y2438
P
Y
T
G
N
P
Q
Y
S
Y
N
N
W
S
P
Site 167
Y2440
T
G
N
P
Q
Y
S
Y
N
N
W
S
P
P
V
Site 168
S2444
Q
Y
S
Y
N
N
W
S
P
P
V
Q
S
N
E
Site 169
Y2456
S
N
E
T
A
N
G
Y
F
L
E
R
S
H
S
Site 170
S2461
N
G
Y
F
L
E
R
S
H
S
A
R
M
T
L
Site 171
S2463
Y
F
L
E
R
S
H
S
A
R
M
T
L
A
K
Site 172
T2467
R
S
H
S
A
R
M
T
L
A
K
A
C
E
L
Site 173
S2492
A
P
D
E
H
E
P
S
P
S
E
D
A
P
L
Site 174
S2494
D
E
H
E
P
S
P
S
E
D
A
P
L
Y
P
Site 175
Y2500
P
S
E
D
A
P
L
Y
P
H
S
P
A
S
Q
Site 176
S2503
D
A
P
L
Y
P
H
S
P
A
S
Q
Y
Q
Q
Site 177
Y2519
N
H
V
H
G
Q
P
Y
T
G
P
A
A
H
H
Site 178
T2520
H
V
H
G
Q
P
Y
T
G
P
A
A
H
H
L
Site 179
Y2541
G
Q
R
T
Q
E
N
Y
E
G
N
E
E
V
S
Site 180
S2549
E
G
N
E
E
V
S
S
P
Q
M
K
D
Q
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation