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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
KRIT1
Full Name:
Krev interaction trapped protein 1
Alias:
ankyrin repeat-containing protein Krit1; CAM; CCM1; cerebral cavernous malformations 1; cerebral cavernous malformations 1 protein; Krev interaction trapped 1; KRIT1, ankyrin repeat containing
Type:
G protein regulator, misc.
Mass (Da):
84350
Number AA:
UniProt ID:
O00522
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005856
GO:0019898
Uniprot
OncoNet
Molecular Function:
GO:0005515
GO:0005083
PhosphoSite+
KinaseNET
Biological Process:
GO:0007264
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y11
P
E
N
I
E
D
A
Y
V
A
V
I
R
P
K
Site 2
S22
I
R
P
K
N
T
A
S
L
N
S
R
E
Y
R
Site 3
Y28
A
S
L
N
S
R
E
Y
R
A
K
S
Y
E
I
Site 4
S32
S
R
E
Y
R
A
K
S
Y
E
I
L
L
H
E
Site 5
S62
E
T
K
L
Q
G
N
S
E
I
T
Q
G
I
L
Site 6
T76
L
D
Y
V
V
E
T
T
K
P
I
S
P
A
N
Site 7
S80
V
E
T
T
K
P
I
S
P
A
N
Q
G
I
R
Site 8
T121
P
S
V
V
K
D
N
T
K
Y
T
Y
T
P
G
Site 9
Y123
V
V
K
D
N
T
K
Y
T
Y
T
P
G
C
P
Site 10
T124
V
K
D
N
T
K
Y
T
Y
T
P
G
C
P
I
Site 11
Y125
K
D
N
T
K
Y
T
Y
T
P
G
C
P
I
F
Site 12
T126
D
N
T
K
Y
T
Y
T
P
G
C
P
I
F
Y
Site 13
S143
Q
D
I
M
R
V
C
S
E
S
S
T
H
F
A
Site 14
T147
R
V
C
S
E
S
S
T
H
F
A
T
L
T
A
Site 15
T151
E
S
S
T
H
F
A
T
L
T
A
R
M
L
I
Site 16
S181
I
P
A
L
F
R
P
S
P
L
E
R
I
K
T
Site 17
T188
S
P
L
E
R
I
K
T
N
V
I
N
P
A
Y
Site 18
Y195
T
N
V
I
N
P
A
Y
A
T
E
S
G
Q
T
Site 19
T202
Y
A
T
E
S
G
Q
T
E
N
S
L
H
M
G
Site 20
S205
E
S
G
Q
T
E
N
S
L
H
M
G
Y
S
A
Site 21
Y230
E
K
A
D
T
C
I
Y
N
P
L
F
G
S
D
Site 22
Y240
L
F
G
S
D
L
Q
Y
T
N
R
V
D
K
V
Site 23
T241
F
G
S
D
L
Q
Y
T
N
R
V
D
K
V
V
Site 24
Y252
D
K
V
V
I
N
P
Y
F
G
L
G
A
P
D
Site 25
Y260
F
G
L
G
A
P
D
Y
S
K
I
Q
I
P
K
Site 26
S274
K
Q
E
K
W
Q
R
S
M
S
S
V
T
E
D
Site 27
S276
E
K
W
Q
R
S
M
S
S
V
T
E
D
K
E
Site 28
S301
R
S
A
C
E
G
D
S
E
L
L
S
R
L
L
Site 29
S305
E
G
D
S
E
L
L
S
R
L
L
S
E
R
F
Site 30
S309
E
L
L
S
R
L
L
S
E
R
F
S
V
N
Q
Site 31
S313
R
L
L
S
E
R
F
S
V
N
Q
L
D
S
D
Site 32
T380
I
L
L
N
H
P
E
T
D
R
H
I
T
D
Q
Site 33
T385
P
E
T
D
R
H
I
T
D
Q
Q
G
R
S
P
Site 34
S391
I
T
D
Q
Q
G
R
S
P
L
N
I
C
E
E
Site 35
Y419
K
E
A
I
N
K
P
Y
E
K
V
R
I
Y
R
Site 36
Y425
P
Y
E
K
V
R
I
Y
R
M
D
G
S
Y
R
Site 37
S430
R
I
Y
R
M
D
G
S
Y
R
S
V
E
L
K
Site 38
Y431
I
Y
R
M
D
G
S
Y
R
S
V
E
L
K
H
Site 39
S433
R
M
D
G
S
Y
R
S
V
E
L
K
H
G
N
Site 40
T443
L
K
H
G
N
N
T
T
V
Q
Q
I
M
E
G
Site 41
Y460
L
S
Q
E
T
Q
Q
Y
F
T
I
W
I
C
S
Site 42
Y477
L
S
L
Q
L
K
P
Y
H
K
P
L
Q
H
V
Site 43
T503
N
L
D
P
Q
R
E
T
P
Q
L
F
L
R
R
Site 44
Y544
Y
N
L
L
K
G
F
Y
T
A
P
D
A
K
L
Site 45
Y563
S
L
L
L
Q
I
V
Y
G
N
Y
E
S
K
K
Site 46
Y566
L
Q
I
V
Y
G
N
Y
E
S
K
K
H
K
Q
Site 47
S583
L
N
E
E
N
L
K
S
I
V
P
V
T
K
L
Site 48
T588
L
K
S
I
V
P
V
T
K
L
K
S
K
A
P
Site 49
S592
V
P
V
T
K
L
K
S
K
A
P
H
W
T
N
Site 50
Y605
T
N
R
I
L
H
E
Y
K
N
L
S
T
S
E
Site 51
S609
L
H
E
Y
K
N
L
S
T
S
E
G
V
S
K
Site 52
S611
E
Y
K
N
L
S
T
S
E
G
V
S
K
E
M
Site 53
S615
L
S
T
S
E
G
V
S
K
E
M
H
H
L
Q
Site 54
S649
G
Q
I
F
T
K
A
S
P
S
N
H
K
V
I
Site 55
S651
I
F
T
K
A
S
P
S
N
H
K
V
I
P
V
Site 56
Y659
N
H
K
V
I
P
V
Y
V
G
V
N
I
K
G
Site 57
T732
L
N
G
Q
L
M
P
T
E
R
N
S
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation