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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PES1
Full Name:
Pescadillo homolog
Alias:
PES; PESC; Pescadillo 1, containing BRCT domain; Pescadillo homolog 1
Type:
Translation
Mass (Da):
68003
Number AA:
588
UniProt ID:
O00541
International Prot ID:
IPI00003768
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0070545
GO:0005654
GO:0030687
Uniprot
OncoNet
Molecular Function:
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0008283
GO:0000466
GO:0000463
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y9
G
G
L
E
K
K
K
Y
E
R
G
S
A
T
N
Site 2
S13
K
K
K
Y
E
R
G
S
A
T
N
Y
I
T
R
Site 3
Y17
E
R
G
S
A
T
N
Y
I
T
R
N
K
A
R
Site 4
S30
A
R
K
K
L
Q
L
S
L
A
D
F
R
R
L
Site 5
Y44
L
C
I
L
K
G
I
Y
P
H
E
P
K
H
K
Site 6
T63
K
G
S
T
A
A
R
T
F
Y
L
I
K
D
I
Site 7
Y65
S
T
A
A
R
T
F
Y
L
I
K
D
I
R
F
Site 8
Y85
I
V
N
K
F
R
E
Y
K
V
F
V
R
K
L
Site 9
Y96
V
R
K
L
R
K
A
Y
G
K
S
E
W
N
T
Site 10
S99
L
R
K
A
Y
G
K
S
E
W
N
T
V
E
R
Site 11
T103
Y
G
K
S
E
W
N
T
V
E
R
L
K
D
N
Site 12
Y114
L
K
D
N
K
P
N
Y
K
L
D
H
I
I
K
Site 13
Y124
D
H
I
I
K
E
R
Y
P
T
F
I
D
A
L
Site 14
T126
I
I
K
E
R
Y
P
T
F
I
D
A
L
R
D
Site 15
Y171
L
T
V
E
F
M
H
Y
I
I
A
A
R
A
L
Site 16
Y217
D
H
P
T
D
V
D
Y
R
V
M
A
T
F
T
Site 17
Y246
Y
Q
L
L
N
L
H
Y
P
P
K
L
E
G
Q
Site 18
Y265
A
K
A
G
E
G
T
Y
A
L
D
S
E
S
C
Site 19
S269
E
G
T
Y
A
L
D
S
E
S
C
M
E
K
L
Site 20
S271
T
Y
A
L
D
S
E
S
C
M
E
K
L
A
A
Site 21
S355
R
S
F
G
G
E
V
S
W
D
K
S
L
C
I
Site 22
S359
G
E
V
S
W
D
K
S
L
C
I
G
A
T
Y
Site 23
T365
K
S
L
C
I
G
A
T
Y
D
V
T
D
S
R
Site 24
T369
I
G
A
T
Y
D
V
T
D
S
R
I
T
H
Q
Site 25
T374
D
V
T
D
S
R
I
T
H
Q
I
V
D
R
P
Site 26
T385
V
D
R
P
G
Q
Q
T
S
V
I
G
R
C
Y
Site 27
S386
D
R
P
G
Q
Q
T
S
V
I
G
R
C
Y
V
Site 28
S424
V
Q
L
P
P
H
L
S
P
F
V
T
E
K
E
Site 29
T428
P
H
L
S
P
F
V
T
E
K
E
G
D
Y
V
Site 30
Y434
V
T
E
K
E
G
D
Y
V
P
P
E
K
L
K
Site 31
S457
D
P
G
N
L
N
E
S
E
E
E
E
E
E
D
Site 32
S488
E
E
D
A
E
A
G
S
E
K
E
E
E
A
R
Site 33
T515
K
P
R
V
M
A
G
T
L
K
L
E
D
K
Q
Site 34
S530
R
L
A
Q
E
E
E
S
E
A
K
R
L
A
I
Site 35
Y546
M
M
K
K
R
E
K
Y
L
Y
Q
K
I
M
F
Site 36
Y548
K
K
R
E
K
Y
L
Y
Q
K
I
M
F
G
K
Site 37
S578
A
H
D
E
A
V
R
S
E
K
K
A
K
K
A
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation