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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
CACNA1A
Full Name:
Voltage-dependent P/Q-type calcium channel subunit alpha-1A
Alias:
APCA; BI; Brain calcium channel I; CAC1A; CACH4; CACN3; CACNL1A4; Calcium channel, L type, alpha-1 polypeptide isoform 4; Calcium channel, voltage-dependent, P/Q type, alpha 1A subunit; CAV2.1; EA2; FHM; HPCA; MHP; MHP1; SCA6; Voltage-dependent P/Q-type calcium channel alpha-1A; Voltage-gated calcium channel alpha subunit Cav2.1; Voltage-gated calcium channel subunit alpha Cav2.1
Type:
Ion channel for calcium
Mass (Da):
282365
Number AA:
2505
UniProt ID:
O00555
International Prot ID:
IPI00291347
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0005509
GO:0019905
GO:0005245
PhosphoSite+
KinaseNET
Biological Process:
GO:0006816
GO:0008219
GO:0007204
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y12
G
D
E
M
P
A
R
Y
G
G
G
G
S
G
A
Site 2
S36
G
G
R
G
A
G
G
S
R
Q
G
G
Q
P
G
Site 3
Y48
Q
P
G
A
Q
R
M
Y
K
Q
S
M
A
Q
R
Site 4
S51
A
Q
R
M
Y
K
Q
S
M
A
Q
R
A
R
T
Site 5
T58
S
M
A
Q
R
A
R
T
M
A
L
Y
N
P
I
Site 6
Y62
R
A
R
T
M
A
L
Y
N
P
I
P
V
R
Q
Site 7
S82
N
R
S
L
F
L
F
S
E
D
N
V
V
R
K
Site 8
Y90
E
D
N
V
V
R
K
Y
A
K
K
I
T
E
W
Site 9
T95
R
K
Y
A
K
K
I
T
E
W
P
P
F
E
Y
Site 10
T127
H
L
P
D
D
D
K
T
P
M
S
E
R
L
D
Site 11
S130
D
D
D
K
T
P
M
S
E
R
L
D
D
T
E
Site 12
T136
M
S
E
R
L
D
D
T
E
P
Y
F
I
G
I
Site 13
Y164
F
A
F
H
K
G
S
Y
L
R
N
G
W
N
V
Site 14
S268
T
D
D
I
Q
G
E
S
P
A
P
C
G
T
E
Site 15
T274
E
S
P
A
P
C
G
T
E
E
P
A
R
T
C
Site 16
T280
G
T
E
E
P
A
R
T
C
P
N
G
T
K
C
Site 17
Y290
N
G
T
K
C
Q
P
Y
W
E
G
P
N
N
G
Site 18
T299
E
G
P
N
N
G
I
T
Q
F
D
N
I
L
F
Site 19
Y325
E
G
W
T
D
L
L
Y
N
S
N
D
A
S
G
Site 20
S327
W
T
D
L
L
Y
N
S
N
D
A
S
G
N
T
Site 21
Y392
I
E
R
E
L
N
G
Y
M
E
W
I
S
K
A
Site 22
T409
V
I
L
A
E
D
E
T
D
G
E
Q
R
H
P
Site 23
T424
F
D
G
A
L
R
R
T
T
I
K
K
S
K
T
Site 24
T425
D
G
A
L
R
R
T
T
I
K
K
S
K
T
D
Site 25
S429
R
R
T
T
I
K
K
S
K
T
D
L
L
N
P
Site 26
T431
T
T
I
K
K
S
K
T
D
L
L
N
P
E
E
Site 27
S448
D
Q
L
A
D
I
A
S
V
G
S
P
F
A
R
Site 28
S457
G
S
P
F
A
R
A
S
I
K
S
A
K
L
E
Site 29
S460
F
A
R
A
S
I
K
S
A
K
L
E
N
S
T
Site 30
T467
S
A
K
L
E
N
S
T
F
F
H
K
K
E
R
Site 31
Y479
K
E
R
R
M
R
F
Y
I
R
R
M
V
K
T
Site 32
Y539
S
E
M
F
I
K
M
Y
G
L
G
T
R
P
Y
Site 33
Y546
Y
G
L
G
T
R
P
Y
F
H
S
S
F
N
C
Site 34
Y596
R
I
F
K
V
T
K
Y
W
A
S
L
R
N
L
Site 35
S599
K
V
T
K
Y
W
A
S
L
R
N
L
V
V
S
Site 36
T646
Q
F
N
F
D
E
G
T
P
P
T
N
F
D
T
Site 37
Y675
E
D
W
N
E
V
M
Y
D
G
I
K
S
Q
G
Site 38
S680
V
M
Y
D
G
I
K
S
Q
G
G
V
Q
G
G
Site 39
S750
A
K
E
V
A
E
V
S
P
L
S
A
A
N
M
Site 40
S753
V
A
E
V
S
P
L
S
A
A
N
M
S
I
A
Site 41
S773
K
N
Q
K
P
A
K
S
V
W
E
Q
R
T
S
Site 42
S780
S
V
W
E
Q
R
T
S
E
M
R
K
Q
N
L
Site 43
S790
R
K
Q
N
L
L
A
S
R
E
A
L
Y
N
E
Site 44
Y795
L
A
S
R
E
A
L
Y
N
E
M
D
P
D
E
Site 45
Y808
D
E
R
W
K
A
A
Y
T
R
H
L
R
P
D
Site 46
T818
H
L
R
P
D
M
K
T
H
L
D
R
P
L
V
Site 47
S839
R
N
N
N
T
N
K
S
R
A
A
E
P
T
V
Site 48
T845
K
S
R
A
A
E
P
T
V
D
Q
R
L
G
Q
Site 49
Y865
F
L
R
K
Q
A
R
Y
H
D
R
A
R
D
P
Site 50
S873
H
D
R
A
R
D
P
S
G
S
A
G
L
D
A
Site 51
S875
R
A
R
D
P
S
G
S
A
G
L
D
A
R
R
Site 52
S887
A
R
R
P
W
A
G
S
Q
E
A
E
L
S
R
Site 53
S893
G
S
Q
E
A
E
L
S
R
E
G
P
Y
G
R
Site 54
Y898
E
L
S
R
E
G
P
Y
G
R
E
S
D
H
H
Site 55
S902
E
G
P
Y
G
R
E
S
D
H
H
A
R
E
G
Site 56
S910
D
H
H
A
R
E
G
S
L
E
Q
P
G
F
W
Site 57
S940
H
V
H
R
Q
G
G
S
R
E
S
R
S
G
S
Site 58
S943
R
Q
G
G
S
R
E
S
R
S
G
S
P
R
T
Site 59
S945
G
G
S
R
E
S
R
S
G
S
P
R
T
G
A
Site 60
S947
S
R
E
S
R
S
G
S
P
R
T
G
A
D
G
Site 61
T950
S
R
S
G
S
P
R
T
G
A
D
G
E
H
R
Site 62
S984
R
A
R
H
R
E
G
S
R
P
A
R
G
G
E
Site 63
Y1014
R
H
G
A
P
A
T
Y
E
G
D
A
R
R
E
Site 64
S1036
R
R
K
E
N
Q
G
S
G
V
P
V
S
G
P
Site 65
S1041
Q
G
S
G
V
P
V
S
G
P
N
L
S
T
T
Site 66
S1046
P
V
S
G
P
N
L
S
T
T
R
P
I
Q
Q
Site 67
T1047
V
S
G
P
N
L
S
T
T
R
P
I
Q
Q
D
Site 68
T1048
S
G
P
N
L
S
T
T
R
P
I
Q
Q
D
L
Site 69
S1079
N
K
L
A
T
A
E
S
A
A
P
H
G
S
L
Site 70
S1085
E
S
A
A
P
H
G
S
L
G
H
A
G
L
P
Site 71
S1094
G
H
A
G
L
P
Q
S
P
A
K
M
G
N
S
Site 72
S1101
S
P
A
K
M
G
N
S
T
D
P
G
P
M
L
Site 73
S1122
T
N
P
Q
N
A
A
S
R
R
T
P
N
N
P
Site 74
T1125
Q
N
A
A
S
R
R
T
P
N
N
P
G
N
P
Site 75
S1133
P
N
N
P
G
N
P
S
N
P
G
P
P
K
T
Site 76
T1140
S
N
P
G
P
P
K
T
P
E
N
S
L
I
V
Site 77
S1144
P
P
K
T
P
E
N
S
L
I
V
T
N
P
S
Site 78
T1148
P
E
N
S
L
I
V
T
N
P
S
G
T
Q
T
Site 79
S1151
S
L
I
V
T
N
P
S
G
T
Q
T
N
S
A
Site 80
T1155
T
N
P
S
G
T
Q
T
N
S
A
K
T
A
R
Site 81
T1160
T
Q
T
N
S
A
K
T
A
R
K
P
D
H
T
Site 82
T1167
T
A
R
K
P
D
H
T
T
V
D
I
P
P
A
Site 83
T1168
A
R
K
P
D
H
T
T
V
D
I
P
P
A
C
Site 84
T1182
C
P
P
P
L
N
H
T
V
V
Q
V
N
K
N
Site 85
Y1221
G
P
K
P
M
P
P
Y
S
S
M
F
I
L
S
Site 86
S1222
P
K
P
M
P
P
Y
S
S
M
F
I
L
S
T
Site 87
S1223
K
P
M
P
P
Y
S
S
M
F
I
L
S
T
T
Site 88
S1228
Y
S
S
M
F
I
L
S
T
T
N
P
L
R
R
Site 89
T1229
S
S
M
F
I
L
S
T
T
N
P
L
R
R
L
Site 90
Y1279
P
R
N
N
V
L
R
Y
F
D
Y
V
F
T
G
Site 91
T1341
S
K
G
K
D
I
N
T
I
K
S
L
R
V
L
Site 92
T1356
R
V
L
R
P
L
K
T
I
K
R
L
P
K
L
Site 93
T1407
K
G
K
F
F
H
C
T
D
E
S
K
E
F
E
Site 94
Y1421
E
K
D
C
R
G
K
Y
L
L
Y
E
K
N
E
Site 95
Y1424
C
R
G
K
Y
L
L
Y
E
K
N
E
V
K
A
Site 96
Y1439
R
D
R
E
W
K
K
Y
E
F
H
Y
D
N
V
Site 97
Y1443
W
K
K
Y
E
F
H
Y
D
N
V
L
W
A
L
Site 98
T1473
L
K
H
S
V
D
A
T
F
E
N
Q
G
P
S
Site 99
S1480
T
F
E
N
Q
G
P
S
P
G
Y
R
M
E
M
Site 100
Y1483
N
Q
G
P
S
P
G
Y
R
M
E
M
S
I
F
Site 101
S1526
D
K
M
M
E
E
Y
S
L
E
K
N
E
R
A
Site 102
T1545
A
I
S
A
K
P
L
T
R
H
M
P
Q
N
K
Site 103
S1726
I
D
V
E
D
E
D
S
D
E
D
E
F
Q
I
Site 104
T1741
T
E
H
N
N
F
R
T
F
F
Q
A
L
M
L
Site 105
S1775
G
K
P
C
D
K
N
S
G
I
L
T
R
E
C
Site 106
T1779
D
K
N
S
G
I
L
T
R
E
C
G
N
E
F
Site 107
Y1816
V
I
M
D
N
F
E
Y
L
T
R
D
S
S
I
Site 108
T1818
M
D
N
F
E
Y
L
T
R
D
S
S
I
L
G
Site 109
S1821
F
E
Y
L
T
R
D
S
S
I
L
G
P
H
H
Site 110
S1822
E
Y
L
T
R
D
S
S
I
L
G
P
H
H
L
Site 111
Y1832
G
P
H
H
L
D
E
Y
V
R
V
W
A
E
Y
Site 112
Y1839
Y
V
R
V
W
A
E
Y
D
P
A
A
W
G
R
Site 113
Y1849
A
A
W
G
R
M
P
Y
L
D
M
Y
Q
M
L
Site 114
Y1853
R
M
P
Y
L
D
M
Y
Q
M
L
R
H
M
S
Site 115
S1860
Y
Q
M
L
R
H
M
S
P
P
L
G
L
G
K
Site 116
Y1875
K
C
P
A
R
V
A
Y
K
R
L
L
R
M
D
Site 117
T1890
L
P
V
A
D
D
N
T
V
H
F
N
S
T
L
Site 118
T1944
K
T
L
D
L
L
V
T
P
H
K
S
T
D
L
Site 119
S1948
L
L
V
T
P
H
K
S
T
D
L
T
V
G
K
Site 120
T1952
P
H
K
S
T
D
L
T
V
G
K
I
Y
A
A
Site 121
Y1965
A
A
M
M
I
M
E
Y
Y
R
Q
S
K
A
K
Site 122
S1969
I
M
E
Y
Y
R
Q
S
K
A
K
K
L
Q
A
Site 123
T1984
M
R
E
E
Q
D
R
T
P
L
M
F
Q
R
M
Site 124
S1995
F
Q
R
M
E
P
P
S
P
T
Q
E
G
G
P
Site 125
T1997
R
M
E
P
P
S
P
T
Q
E
G
G
P
G
Q
Site 126
S2009
P
G
Q
N
A
L
P
S
T
Q
L
D
P
G
G
Site 127
S2023
G
A
L
M
A
H
E
S
G
L
K
E
S
P
S
Site 128
S2028
H
E
S
G
L
K
E
S
P
S
W
V
T
Q
R
Site 129
S2030
S
G
L
K
E
S
P
S
W
V
T
Q
R
A
Q
Site 130
T2043
A
Q
E
M
F
Q
K
T
G
T
W
S
P
E
Q
Site 131
T2045
E
M
F
Q
K
T
G
T
W
S
P
E
Q
G
P
Site 132
S2047
F
Q
K
T
G
T
W
S
P
E
Q
G
P
P
T
Site 133
T2054
S
P
E
Q
G
P
P
T
D
M
P
N
S
Q
P
Site 134
S2059
P
P
T
D
M
P
N
S
Q
P
N
S
Q
S
V
Site 135
S2063
M
P
N
S
Q
P
N
S
Q
S
V
E
M
R
E
Site 136
S2065
N
S
Q
P
N
S
Q
S
V
E
M
R
E
M
G
Site 137
Y2076
R
E
M
G
R
D
G
Y
S
D
S
E
H
Y
L
Site 138
S2077
E
M
G
R
D
G
Y
S
D
S
E
H
Y
L
P
Site 139
S2079
G
R
D
G
Y
S
D
S
E
H
Y
L
P
M
E
Site 140
Y2082
G
Y
S
D
S
E
H
Y
L
P
M
E
G
Q
G
Site 141
S2093
E
G
Q
G
R
A
A
S
M
P
R
L
P
A
E
Site 142
S2114
R
P
R
G
N
N
L
S
T
I
S
D
T
S
P
Site 143
T2115
P
R
G
N
N
L
S
T
I
S
D
T
S
P
M
Site 144
S2117
G
N
N
L
S
T
I
S
D
T
S
P
M
K
R
Site 145
S2120
L
S
T
I
S
D
T
S
P
M
K
R
S
A
S
Site 146
S2125
D
T
S
P
M
K
R
S
A
S
V
L
G
P
K
Site 147
S2127
S
P
M
K
R
S
A
S
V
L
G
P
K
A
R
Site 148
Y2139
K
A
R
R
L
D
D
Y
S
L
E
R
V
P
P
Site 149
S2140
A
R
R
L
D
D
Y
S
L
E
R
V
P
P
E
Site 150
S2160
H
Q
R
R
R
D
R
S
H
R
A
S
E
R
S
Site 151
S2164
R
D
R
S
H
R
A
S
E
R
S
L
G
R
Y
Site 152
S2167
S
H
R
A
S
E
R
S
L
G
R
Y
T
D
V
Site 153
Y2171
S
E
R
S
L
G
R
Y
T
D
V
D
T
G
L
Site 154
T2172
E
R
S
L
G
R
Y
T
D
V
D
T
G
L
G
Site 155
T2176
G
R
Y
T
D
V
D
T
G
L
G
T
D
L
S
Site 156
S2183
T
G
L
G
T
D
L
S
M
T
T
Q
S
G
D
Site 157
S2193
T
Q
S
G
D
L
P
S
K
E
R
D
Q
E
R
Site 158
Y2229
P
P
P
D
K
D
R
Y
A
Q
E
R
P
D
H
Site 159
S2247
R
A
R
D
Q
R
W
S
R
S
P
S
E
G
R
Site 160
S2249
R
D
Q
R
W
S
R
S
P
S
E
G
R
E
H
Site 161
S2251
Q
R
W
S
R
S
P
S
E
G
R
E
H
M
A
Site 162
S2263
H
M
A
H
R
Q
G
S
S
S
V
S
G
S
P
Site 163
S2265
A
H
R
Q
G
S
S
S
V
S
G
S
P
A
P
Site 164
S2267
R
Q
G
S
S
S
V
S
G
S
P
A
P
S
T
Site 165
S2269
G
S
S
S
V
S
G
S
P
A
P
S
T
S
G
Site 166
S2273
V
S
G
S
P
A
P
S
T
S
G
T
S
T
P
Site 167
T2274
S
G
S
P
A
P
S
T
S
G
T
S
T
P
R
Site 168
S2275
G
S
P
A
P
S
T
S
G
T
S
T
P
R
R
Site 169
T2277
P
A
P
S
T
S
G
T
S
T
P
R
R
G
R
Site 170
S2278
A
P
S
T
S
G
T
S
T
P
R
R
G
R
R
Site 171
T2279
P
S
T
S
G
T
S
T
P
R
R
G
R
R
Q
Site 172
T2290
G
R
R
Q
L
P
Q
T
P
S
T
P
R
P
H
Site 173
S2292
R
Q
L
P
Q
T
P
S
T
P
R
P
H
V
S
Site 174
T2293
Q
L
P
Q
T
P
S
T
P
R
P
H
V
S
Y
Site 175
S2299
S
T
P
R
P
H
V
S
Y
S
P
V
I
R
K
Site 176
Y2300
T
P
R
P
H
V
S
Y
S
P
V
I
R
K
A
Site 177
S2301
P
R
P
H
V
S
Y
S
P
V
I
R
K
A
G
Site 178
S2310
V
I
R
K
A
G
G
S
G
P
P
Q
Q
Q
Q
Site 179
T2334
A
R
P
G
R
A
A
T
S
G
P
R
R
Y
P
Site 180
S2335
R
P
G
R
A
A
T
S
G
P
R
R
Y
P
G
Site 181
Y2340
A
T
S
G
P
R
R
Y
P
G
P
T
A
E
P
Site 182
T2344
P
R
R
Y
P
G
P
T
A
E
P
L
A
G
D
Site 183
T2355
L
A
G
D
R
P
P
T
G
G
H
S
S
G
R
Site 184
S2359
R
P
P
T
G
G
H
S
S
G
R
S
P
R
M
Site 185
S2360
P
P
T
G
G
H
S
S
G
R
S
P
R
M
E
Site 186
S2363
G
G
H
S
S
G
R
S
P
R
M
E
R
R
V
Site 187
S2376
R
V
P
G
P
A
R
S
E
S
P
R
A
C
R
Site 188
S2378
P
G
P
A
R
S
E
S
P
R
A
C
R
H
G
Site 189
S2392
G
G
A
R
W
P
A
S
G
P
H
V
S
E
G
Site 190
S2397
P
A
S
G
P
H
V
S
E
G
P
P
G
P
R
Site 191
Y2408
P
G
P
R
H
H
G
Y
Y
R
G
S
D
Y
D
Site 192
Y2409
G
P
R
H
H
G
Y
Y
R
G
S
D
Y
D
E
Site 193
S2412
H
H
G
Y
Y
R
G
S
D
Y
D
E
A
D
G
Site 194
Y2414
G
Y
Y
R
G
S
D
Y
D
E
A
D
G
P
G
Site 195
S2422
D
E
A
D
G
P
G
S
G
G
G
E
E
A
M
Site 196
Y2433
E
E
A
M
A
G
A
Y
D
A
P
P
P
V
R
Site 197
S2443
P
P
P
V
R
H
A
S
S
G
A
T
G
R
S
Site 198
S2444
P
P
V
R
H
A
S
S
G
A
T
G
R
S
P
Site 199
T2447
R
H
A
S
S
G
A
T
G
R
S
P
R
T
P
Site 200
S2450
S
S
G
A
T
G
R
S
P
R
T
P
R
A
S
Site 201
T2453
A
T
G
R
S
P
R
T
P
R
A
S
G
P
A
Site 202
S2457
S
P
R
T
P
R
A
S
G
P
A
C
A
S
P
Site 203
S2463
A
S
G
P
A
C
A
S
P
S
R
H
G
R
R
Site 204
Y2475
G
R
R
L
P
N
G
Y
Y
P
A
H
G
L
A
Site 205
Y2476
R
R
L
P
N
G
Y
Y
P
A
H
G
L
A
R
Site 206
S2489
A
R
P
R
G
P
G
S
R
K
G
L
H
E
P
Site 207
S2498
K
G
L
H
E
P
Y
S
E
S
D
D
D
W
C
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation