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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PITPNM1
Full Name:
Membrane-associated phosphatidylinositol transfer protein 1
Alias:
NIR2; PITM1; Pyk2 N-terminal domain-interacting receptor 2; RDGB
Type:
Cell surface protein
Mass (Da):
134848
Number AA:
1244
UniProt ID:
O00562
International Prot ID:
IPI00783532
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005794
GO:0005783
GO:0019898
Uniprot
OncoNet
Molecular Function:
GO:0005509
GO:0008526
PhosphoSite+
KinaseNET
Biological Process:
GO:0007420
GO:0006629
GO:0007602
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y23
E
Y
Q
V
A
Q
L
Y
M
I
Q
K
K
S
R
Site 2
S29
L
Y
M
I
Q
K
K
S
R
E
E
S
S
G
E
Site 3
S33
Q
K
K
S
R
E
E
S
S
G
E
G
S
G
V
Site 4
S34
K
K
S
R
E
E
S
S
G
E
G
S
G
V
E
Site 5
S38
E
E
S
S
G
E
G
S
G
V
E
I
L
A
N
Site 6
Y48
E
I
L
A
N
R
P
Y
T
D
G
P
G
G
S
Site 7
T49
I
L
A
N
R
P
Y
T
D
G
P
G
G
S
G
Site 8
Y58
G
P
G
G
S
G
Q
Y
T
H
K
V
Y
H
V
Site 9
T59
P
G
G
S
G
Q
Y
T
H
K
V
Y
H
V
G
Site 10
Y63
G
Q
Y
T
H
K
V
Y
H
V
G
S
H
I
P
Site 11
Y92
E
E
E
S
W
N
A
Y
P
Y
T
R
T
R
Y
Site 12
Y94
E
S
W
N
A
Y
P
Y
T
R
T
R
Y
T
C
Site 13
Y99
Y
P
Y
T
R
T
R
Y
T
C
P
F
V
E
K
Site 14
T100
P
Y
T
R
T
R
Y
T
C
P
F
V
E
K
F
Site 15
Y114
F
S
I
E
I
E
T
Y
Y
L
P
D
G
G
Q
Site 16
Y115
S
I
E
I
E
T
Y
Y
L
P
D
G
G
Q
Q
Site 17
S129
Q
P
N
V
F
N
L
S
G
A
E
R
R
Q
R
Site 18
T140
R
R
Q
R
I
L
D
T
I
D
I
V
R
D
A
Site 19
Y162
A
E
E
D
P
R
L
Y
H
S
V
K
T
G
R
Site 20
S164
E
D
P
R
L
Y
H
S
V
K
T
G
R
G
P
Site 21
T167
R
L
Y
H
S
V
K
T
G
R
G
P
L
S
D
Site 22
S173
K
T
G
R
G
P
L
S
D
D
W
A
R
T
A
Site 23
Y190
T
G
P
L
M
C
A
Y
K
L
C
K
V
E
F
Site 24
S237
Q
D
E
W
T
E
L
S
M
A
D
I
R
A
L
Site 25
S275
A
Q
P
P
G
K
P
S
T
E
A
R
S
A
A
Site 26
T276
Q
P
P
G
K
P
S
T
E
A
R
S
A
A
S
Site 27
T287
S
A
A
S
N
T
G
T
P
D
G
P
E
A
P
Site 28
S300
A
P
P
G
P
D
A
S
P
D
A
S
F
G
K
Site 29
S304
P
D
A
S
P
D
A
S
F
G
K
Q
W
S
S
Site 30
S310
A
S
F
G
K
Q
W
S
S
S
S
R
S
S
Y
Site 31
S311
S
F
G
K
Q
W
S
S
S
S
R
S
S
Y
S
Site 32
S312
F
G
K
Q
W
S
S
S
S
R
S
S
Y
S
S
Site 33
S313
G
K
Q
W
S
S
S
S
R
S
S
Y
S
S
Q
Site 34
S315
Q
W
S
S
S
S
R
S
S
Y
S
S
Q
H
G
Site 35
S316
W
S
S
S
S
R
S
S
Y
S
S
Q
H
G
G
Site 36
Y317
S
S
S
S
R
S
S
Y
S
S
Q
H
G
G
A
Site 37
S318
S
S
S
R
S
S
Y
S
S
Q
H
G
G
A
V
Site 38
S319
S
S
R
S
S
Y
S
S
Q
H
G
G
A
V
S
Site 39
S326
S
Q
H
G
G
A
V
S
P
Q
S
L
S
E
W
Site 40
S329
G
G
A
V
S
P
Q
S
L
S
E
W
R
M
Q
Site 41
S331
A
V
S
P
Q
S
L
S
E
W
R
M
Q
N
I
Site 42
S342
M
Q
N
I
A
R
D
S
E
N
S
S
E
E
E
Site 43
S345
I
A
R
D
S
E
N
S
S
E
E
E
F
F
D
Site 44
S346
A
R
D
S
E
N
S
S
E
E
E
F
F
D
A
Site 45
S360
A
H
E
G
F
S
D
S
E
E
V
F
P
K
E
Site 46
S382
D
F
I
D
A
F
A
S
P
V
E
A
E
G
T
Site 47
T389
S
P
V
E
A
E
G
T
P
E
P
G
A
E
A
Site 48
S410
G
A
Q
A
P
R
D
S
E
G
L
D
G
A
G
Site 49
S441
H
S
G
N
I
L
D
S
G
P
G
D
A
N
S
Site 50
S448
S
G
P
G
D
A
N
S
K
Q
A
D
V
Q
T
Site 51
T455
S
K
Q
A
D
V
Q
T
L
S
S
A
F
E
A
Site 52
S497
Y
A
L
V
S
N
L
S
P
Y
S
H
D
G
D
Site 53
Y499
L
V
S
N
L
S
P
Y
S
H
D
G
D
S
L
Site 54
S500
V
S
N
L
S
P
Y
S
H
D
G
D
S
L
S
Site 55
S505
P
Y
S
H
D
G
D
S
L
S
R
S
Q
D
H
Site 56
S507
S
H
D
G
D
S
L
S
R
S
Q
D
H
I
P
Site 57
S509
D
G
D
S
L
S
R
S
Q
D
H
I
P
L
A
Site 58
S526
P
L
L
A
T
S
S
S
R
Y
Q
G
A
V
A
Site 59
T534
R
Y
Q
G
A
V
A
T
V
I
A
R
T
N
Q
Site 60
Y543
I
A
R
T
N
Q
A
Y
S
A
F
L
R
S
P
Site 61
S578
G
F
D
A
L
C
H
S
A
N
A
G
T
G
S
Site 62
S585
S
A
N
A
G
T
G
S
R
G
S
S
R
R
G
Site 63
S588
A
G
T
G
S
R
G
S
S
R
R
G
S
M
N
Site 64
S589
G
T
G
S
R
G
S
S
R
R
G
S
M
N
N
Site 65
S593
R
G
S
S
R
R
G
S
M
N
N
E
L
L
S
Site 66
S600
S
M
N
N
E
L
L
S
P
E
F
G
P
V
R
Site 67
S621
V
E
G
L
G
R
G
S
P
E
P
S
A
L
P
Site 68
S625
G
R
G
S
P
E
P
S
A
L
P
P
Q
R
I
Site 69
S634
L
P
P
Q
R
I
P
S
D
M
A
S
P
E
P
Site 70
S638
R
I
P
S
D
M
A
S
P
E
P
E
G
S
Q
Site 71
S644
A
S
P
E
P
E
G
S
Q
N
S
L
Q
A
A
Site 72
S647
E
P
E
G
S
Q
N
S
L
Q
A
A
P
A
T
Site 73
T654
S
L
Q
A
A
P
A
T
T
S
S
W
E
P
R
Site 74
S657
A
A
P
A
T
T
S
S
W
E
P
R
R
A
S
Site 75
S664
S
W
E
P
R
R
A
S
T
A
F
C
P
P
A
Site 76
T665
W
E
P
R
R
A
S
T
A
F
C
P
P
A
A
Site 77
S674
F
C
P
P
A
A
S
S
E
A
P
D
G
P
S
Site 78
S681
S
E
A
P
D
G
P
S
S
T
A
R
L
D
F
Site 79
S682
E
A
P
D
G
P
S
S
T
A
R
L
D
F
K
Site 80
Y759
A
P
L
T
V
P
R
Y
Q
K
F
P
L
G
D
Site 81
S781
D
T
L
Q
T
H
S
S
L
F
L
E
E
L
E
Site 82
S793
E
L
E
M
L
V
P
S
T
P
T
S
T
S
G
Site 83
T794
L
E
M
L
V
P
S
T
P
T
S
T
S
G
A
Site 84
S797
L
V
P
S
T
P
T
S
T
S
G
A
F
W
K
Site 85
S799
P
S
T
P
T
S
T
S
G
A
F
W
K
G
S
Site 86
S806
S
G
A
F
W
K
G
S
E
L
A
T
D
P
P
Site 87
T810
W
K
G
S
E
L
A
T
D
P
P
A
Q
P
A
Site 88
Y840
W
G
T
K
R
I
D
Y
S
L
Y
C
P
E
A
Site 89
S841
G
T
K
R
I
D
Y
S
L
Y
C
P
E
A
L
Site 90
Y843
K
R
I
D
Y
S
L
Y
C
P
E
A
L
T
A
Site 91
Y864
P
H
L
F
H
A
S
Y
W
E
S
A
D
V
V
Site 92
Y895
E
C
E
E
P
S
I
Y
S
P
A
F
P
R
E
Site 93
S896
C
E
E
P
S
I
Y
S
P
A
F
P
R
E
K
Site 94
T909
E
K
W
Q
R
K
R
T
Q
V
K
I
R
N
V
Site 95
T917
Q
V
K
I
R
N
V
T
S
N
H
R
A
S
D
Site 96
S918
V
K
I
R
N
V
T
S
N
H
R
A
S
D
T
Site 97
S923
V
T
S
N
H
R
A
S
D
T
V
V
C
E
G
Site 98
T925
S
N
H
R
A
S
D
T
V
V
C
E
G
R
P
Site 99
S936
E
G
R
P
Q
V
L
S
G
R
F
M
Y
G
P
Site 100
Y957
T
G
E
K
V
D
V
Y
I
M
T
Q
P
L
S
Site 101
T960
K
V
D
V
Y
I
M
T
Q
P
L
S
G
K
W
Site 102
T972
G
K
W
I
H
F
G
T
E
V
T
N
S
S
G
Site 103
S977
F
G
T
E
V
T
N
S
S
G
R
L
T
F
P
Site 104
S978
G
T
E
V
T
N
S
S
G
R
L
T
F
P
V
Site 105
T982
T
N
S
S
G
R
L
T
F
P
V
P
P
E
R
Site 106
T1020
L
T
V
V
A
R
G
T
E
A
V
V
F
S
I
Site 107
S1036
G
S
F
T
A
S
V
S
I
M
G
S
D
P
K
Site 108
S1040
A
S
V
S
I
M
G
S
D
P
K
V
R
A
G
Site 109
Y1060
R
H
W
Q
D
S
G
Y
L
I
V
Y
V
T
G
Site 110
Y1064
D
S
G
Y
L
I
V
Y
V
T
G
R
P
D
M
Site 111
T1066
G
Y
L
I
V
Y
V
T
G
R
P
D
M
Q
K
Site 112
T1097
V
S
F
C
D
G
L
T
H
D
P
L
R
Q
K
Site 113
S1174
L
G
Q
L
E
A
G
S
H
S
H
A
S
S
G
Site 114
S1176
Q
L
E
A
G
S
H
S
H
A
S
S
G
P
P
Site 115
S1179
A
G
S
H
S
H
A
S
S
G
P
P
R
A
A
Site 116
S1180
G
S
H
S
H
A
S
S
G
P
P
R
A
A
L
Site 117
S1205
V
D
F
L
R
K
Q
S
Q
L
L
R
S
R
G
Site 118
S1210
K
Q
S
Q
L
L
R
S
R
G
P
S
Q
A
E
Site 119
S1214
L
L
R
S
R
G
P
S
Q
A
E
R
E
G
P
Site 120
T1223
A
E
R
E
G
P
G
T
P
P
T
T
L
A
R
Site 121
T1226
E
G
P
G
T
P
P
T
T
L
A
R
G
K
A
Site 122
T1227
G
P
G
T
P
P
T
T
L
A
R
G
K
A
R
Site 123
S1235
L
A
R
G
K
A
R
S
I
S
L
K
L
D
S
Site 124
S1237
R
G
K
A
R
S
I
S
L
K
L
D
S
E
E
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation