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Updated November 2019
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Protein Info
Short Name:
CYR61
Full Name:
Protein CYR61
Alias:
CCN family member 1;Cysteine-rich angiogenic inducer 61;Insulin-like growth factor-binding protein 10;Protein GIG1
Type:
Mass (Da):
42027
Number AA:
381
UniProt ID:
O00622
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T67
L
N
E
D
C
S
K
T
Q
P
C
D
H
T
K
Site 2
T73
K
T
Q
P
C
D
H
T
K
G
L
E
C
N
F
Site 3
S84
E
C
N
F
G
A
S
S
T
A
L
K
G
I
C
Site 4
T85
C
N
F
G
A
S
S
T
A
L
K
G
I
C
R
Site 5
S95
K
G
I
C
R
A
Q
S
E
G
R
P
C
E
Y
Site 6
Y102
S
E
G
R
P
C
E
Y
N
S
R
I
Y
Q
N
Site 7
Y107
C
E
Y
N
S
R
I
Y
Q
N
G
E
S
F
Q
Site 8
S188
K
E
L
G
F
D
A
S
E
V
E
L
T
R
N
Site 9
T193
D
A
S
E
V
E
L
T
R
N
N
E
L
I
A
Site 10
Y221
G
M
E
P
R
I
L
Y
N
P
L
Q
G
Q
K
Site 11
T242
S
W
S
Q
C
S
K
T
C
G
T
G
I
S
T
Site 12
S248
K
T
C
G
T
G
I
S
T
R
V
T
N
D
N
Site 13
T252
T
G
I
S
T
R
V
T
N
D
N
P
E
C
R
Site 14
Y277
R
P
C
G
Q
P
V
Y
S
S
L
K
K
G
K
Site 15
S279
C
G
Q
P
V
Y
S
S
L
K
K
G
K
K
C
Site 16
S287
L
K
K
G
K
K
C
S
K
T
K
K
S
P
E
Site 17
T289
K
G
K
K
C
S
K
T
K
K
S
P
E
P
V
Site 18
S292
K
C
S
K
T
K
K
S
P
E
P
V
R
F
T
Site 19
Y300
P
E
P
V
R
F
T
Y
A
G
C
L
S
V
K
Site 20
S305
F
T
Y
A
G
C
L
S
V
K
K
Y
R
P
K
Site 21
Y309
G
C
L
S
V
K
K
Y
R
P
K
Y
C
G
S
Site 22
Y313
V
K
K
Y
R
P
K
Y
C
G
S
C
V
D
G
Site 23
T324
C
V
D
G
R
C
C
T
P
Q
L
T
R
T
V
Site 24
T330
C
T
P
Q
L
T
R
T
V
K
M
R
F
R
C
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation