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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PIK3C2B
Full Name:
Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing subunit beta
Alias:
C2-PI3K; EC 2.7.1.154; P3C2B; Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing beta; Phosphoinositide 3-kinase-C2-beta; PI3K C2beta; PI3K-C2beta; PK3B; PtdIns-3-kinase C2 beta
Type:
Kinase, Lipid protein
Mass (Da):
184768
Number AA:
1634
UniProt ID:
O00750
International Prot ID:
IPI00292056
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005783
GO:0005792
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0016303
GO:0005524
GO:0035005
PhosphoSite+
KinaseNET
Biological Process:
GO:0046854
GO:0048015
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T4
_
_
_
_
M
S
S
T
Q
G
N
G
E
H
W
Site 2
S13
G
N
G
E
H
W
K
S
L
E
S
V
G
I
S
Site 3
S16
E
H
W
K
S
L
E
S
V
G
I
S
R
K
E
Site 4
S56
A
K
Q
N
A
D
P
S
L
I
S
W
D
E
P
Site 5
S59
N
A
D
P
S
L
I
S
W
D
E
P
G
V
D
Site 6
Y68
D
E
P
G
V
D
F
Y
S
K
P
A
G
R
R
Site 7
S69
E
P
G
V
D
F
Y
S
K
P
A
G
R
R
T
Site 8
T76
S
K
P
A
G
R
R
T
D
L
K
L
L
R
G
Site 9
S85
L
K
L
L
R
G
L
S
G
S
D
P
T
L
N
Site 10
S87
L
L
R
G
L
S
G
S
D
P
T
L
N
Y
N
Site 11
T90
G
L
S
G
S
D
P
T
L
N
Y
N
S
L
S
Site 12
Y93
G
S
D
P
T
L
N
Y
N
S
L
S
P
Q
E
Site 13
S95
D
P
T
L
N
Y
N
S
L
S
P
Q
E
G
P
Site 14
S97
T
L
N
Y
N
S
L
S
P
Q
E
G
P
P
N
Site 15
S106
Q
E
G
P
P
N
H
S
T
S
Q
G
P
Q
P
Site 16
S108
G
P
P
N
H
S
T
S
Q
G
P
Q
P
G
S
Site 17
S115
S
Q
G
P
Q
P
G
S
D
P
W
P
K
G
S
Site 18
S122
S
D
P
W
P
K
G
S
L
S
G
D
Y
L
Y
Site 19
S124
P
W
P
K
G
S
L
S
G
D
Y
L
Y
I
F
Site 20
Y127
K
G
S
L
S
G
D
Y
L
Y
I
F
D
G
S
Site 21
Y129
S
L
S
G
D
Y
L
Y
I
F
D
G
S
D
G
Site 22
S134
Y
L
Y
I
F
D
G
S
D
G
G
V
S
S
S
Site 23
S139
D
G
S
D
G
G
V
S
S
S
P
G
P
G
D
Site 24
S140
G
S
D
G
G
V
S
S
S
P
G
P
G
D
I
Site 25
S141
S
D
G
G
V
S
S
S
P
G
P
G
D
I
E
Site 26
S155
E
G
S
C
K
K
L
S
P
P
P
L
P
P
R
Site 27
S164
P
P
L
P
P
R
A
S
I
W
D
T
P
P
L
Site 28
T168
P
R
A
S
I
W
D
T
P
P
L
P
P
R
K
Site 29
S177
P
L
P
P
R
K
G
S
P
S
S
S
K
I
S
Site 30
S179
P
P
R
K
G
S
P
S
S
S
K
I
S
Q
P
Site 31
S180
P
R
K
G
S
P
S
S
S
K
I
S
Q
P
S
Site 32
S181
R
K
G
S
P
S
S
S
K
I
S
Q
P
S
D
Site 33
S184
S
P
S
S
S
K
I
S
Q
P
S
D
I
N
T
Site 34
S187
S
S
K
I
S
Q
P
S
D
I
N
T
F
S
L
Site 35
T191
S
Q
P
S
D
I
N
T
F
S
L
V
E
Q
L
Site 36
S193
P
S
D
I
N
T
F
S
L
V
E
Q
L
P
G
Site 37
S225
G
Q
G
R
L
L
G
S
V
D
Y
D
G
I
N
Site 38
Y228
R
L
L
G
S
V
D
Y
D
G
I
N
D
A
I
Site 39
T236
D
G
I
N
D
A
I
T
R
L
N
L
K
S
T
Site 40
S242
I
T
R
L
N
L
K
S
T
Y
D
A
E
M
L
Site 41
Y244
R
L
N
L
K
S
T
Y
D
A
E
M
L
R
D
Site 42
T253
A
E
M
L
R
D
A
T
R
G
W
K
E
G
R
Site 43
S266
G
R
G
P
L
D
F
S
K
D
T
S
G
K
P
Site 44
S270
L
D
F
S
K
D
T
S
G
K
P
V
A
R
S
Site 45
S277
S
G
K
P
V
A
R
S
K
T
M
P
P
Q
V
Site 46
T279
K
P
V
A
R
S
K
T
M
P
P
Q
V
P
P
Site 47
T288
P
P
Q
V
P
P
R
T
Y
A
S
R
Y
G
N
Site 48
Y289
P
Q
V
P
P
R
T
Y
A
S
R
Y
G
N
R
Site 49
Y293
P
R
T
Y
A
S
R
Y
G
N
R
K
N
A
T
Site 50
T300
Y
G
N
R
K
N
A
T
P
G
K
N
R
R
I
Site 51
S308
P
G
K
N
R
R
I
S
A
A
P
V
G
S
R
Site 52
T318
P
V
G
S
R
P
H
T
V
A
N
G
H
E
L
Site 53
S329
G
H
E
L
F
E
V
S
E
E
R
D
E
E
V
Site 54
S348
H
M
L
D
I
L
R
S
G
S
D
I
Q
D
Y
Site 55
S350
L
D
I
L
R
S
G
S
D
I
Q
D
Y
F
L
Site 56
Y355
S
G
S
D
I
Q
D
Y
F
L
T
G
Y
V
W
Site 57
T366
G
Y
V
W
S
A
V
T
P
S
P
E
H
L
G
Site 58
S368
V
W
S
A
V
T
P
S
P
E
H
L
G
D
E
Site 59
T381
D
E
V
N
L
K
V
T
V
L
C
D
R
L
Q
Site 60
T392
D
R
L
Q
E
A
L
T
F
T
C
N
C
S
S
Site 61
Y449
G
S
H
E
Y
I
Q
Y
C
R
K
F
D
I
D
Site 62
S469
M
E
Q
K
V
V
R
S
D
L
A
R
T
V
N
Site 63
T474
V
R
S
D
L
A
R
T
V
N
D
D
Q
S
P
Site 64
S480
R
T
V
N
D
D
Q
S
P
S
T
L
N
Y
L
Site 65
T483
N
D
D
Q
S
P
S
T
L
N
Y
L
V
H
L
Site 66
Y486
Q
S
P
S
T
L
N
Y
L
V
H
L
Q
E
R
Site 67
T498
Q
E
R
P
V
K
Q
T
I
S
R
Q
A
L
S
Site 68
S500
R
P
V
K
Q
T
I
S
R
Q
A
L
S
L
L
Site 69
S505
T
I
S
R
Q
A
L
S
L
L
F
D
T
Y
H
Site 70
S563
N
Q
L
P
P
C
P
S
R
M
Q
P
K
I
Q
Site 71
S574
P
K
I
Q
K
D
P
S
V
L
A
V
R
E
N
Site 72
T610
T
F
N
A
D
F
Q
T
A
V
P
G
S
R
K
Site 73
Y653
A
T
S
Y
E
D
F
Y
L
S
C
S
L
S
H
Site 74
S655
S
Y
E
D
F
Y
L
S
C
S
L
S
H
G
G
Site 75
S657
E
D
F
Y
L
S
C
S
L
S
H
G
G
K
E
Site 76
S667
H
G
G
K
E
L
C
S
P
L
Q
T
R
R
A
Site 77
T671
E
L
C
S
P
L
Q
T
R
R
A
H
F
S
K
Site 78
S719
L
P
I
P
P
P
G
S
S
S
E
A
N
K
Q
Site 79
S721
I
P
P
P
G
S
S
S
E
A
N
K
Q
R
R
Site 80
T738
E
A
L
G
W
V
T
T
P
L
F
N
F
R
Q
Site 81
T760
L
L
G
L
W
P
A
T
Q
E
N
P
S
A
R
Site 82
S765
P
A
T
Q
E
N
P
S
A
R
W
S
A
P
N
Site 83
S769
E
N
P
S
A
R
W
S
A
P
N
F
H
Q
P
Site 84
T795
S
A
F
D
I
K
F
T
S
P
P
G
D
K
F
Site 85
S796
A
F
D
I
K
F
T
S
P
P
G
D
K
F
S
Site 86
S803
S
P
P
G
D
K
F
S
P
R
Y
E
F
G
S
Site 87
Y806
G
D
K
F
S
P
R
Y
E
F
G
S
L
R
E
Site 88
S810
S
P
R
Y
E
F
G
S
L
R
E
E
D
Q
R
Site 89
Y844
K
R
L
W
E
K
R
Y
Y
C
H
S
E
V
S
Site 90
Y845
R
L
W
E
K
R
Y
Y
C
H
S
E
V
S
S
Site 91
S848
E
K
R
Y
Y
C
H
S
E
V
S
S
L
P
L
Site 92
T879
Y
V
L
L
K
Q
W
T
H
M
N
H
Q
D
A
Site 93
Y928
Q
L
V
Q
A
L
K
Y
E
C
Y
L
D
S
P
Site 94
Y931
Q
A
L
K
Y
E
C
Y
L
D
S
P
L
V
R
Site 95
Y953
S
D
L
R
V
T
H
Y
F
F
W
L
L
K
D
Site 96
S965
L
K
D
G
L
K
D
S
Q
F
S
I
R
Y
Q
Site 97
S968
G
L
K
D
S
Q
F
S
I
R
Y
Q
Y
L
L
Site 98
S1013
Q
V
R
E
A
A
P
S
A
R
Q
G
I
L
R
Site 99
S1055
G
I
V
P
R
D
C
S
Y
F
N
S
N
A
V
Site 100
Y1056
I
V
P
R
D
C
S
Y
F
N
S
N
A
V
P
Site 101
S1059
R
D
C
S
Y
F
N
S
N
A
V
P
L
K
L
Site 102
T1148
I
Q
V
E
H
G
V
T
G
S
F
K
D
R
P
Site 103
S1150
V
E
H
G
V
T
G
S
F
K
D
R
P
L
A
Site 104
Y1170
H
N
P
G
E
D
E
Y
E
K
A
V
E
N
F
Site 105
S1251
I
N
G
G
D
K
P
S
S
R
F
H
D
F
V
Site 106
S1252
N
G
G
D
K
P
S
S
R
F
H
D
F
V
D
Site 107
Y1265
V
D
L
C
C
Q
A
Y
N
L
I
R
K
H
T
Site 108
S1291
S
C
G
I
P
E
L
S
D
L
E
D
L
K
Y
Site 109
Y1298
S
D
L
E
D
L
K
Y
V
Y
D
A
L
R
P
Site 110
Y1300
L
E
D
L
K
Y
V
Y
D
A
L
R
P
Q
D
Site 111
T1308
D
A
L
R
P
Q
D
T
E
A
N
A
T
T
Y
Site 112
T1313
Q
D
T
E
A
N
A
T
T
Y
F
T
R
L
I
Site 113
Y1315
T
E
A
N
A
T
T
Y
F
T
R
L
I
E
S
Site 114
S1346
A
Q
M
K
F
T
G
S
D
D
R
L
T
L
S
Site 115
T1351
T
G
S
D
D
R
L
T
L
S
F
A
S
R
T
Site 116
S1353
S
D
D
R
L
T
L
S
F
A
S
R
T
H
T
Site 117
T1360
S
F
A
S
R
T
H
T
L
K
S
S
G
R
I
Site 118
S1363
S
R
T
H
T
L
K
S
S
G
R
I
S
D
V
Site 119
S1364
R
T
H
T
L
K
S
S
G
R
I
S
D
V
F
Site 120
S1368
L
K
S
S
G
R
I
S
D
V
F
L
C
R
H
Site 121
Y1387
H
P
N
K
G
Y
I
Y
V
V
K
V
M
R
E
Site 122
T1396
V
K
V
M
R
E
N
T
H
E
A
T
Y
I
Q
Site 123
T1405
E
A
T
Y
I
Q
R
T
F
E
E
F
Q
E
L
Site 124
S1422
K
L
R
L
L
F
P
S
S
H
L
P
S
F
P
Site 125
S1430
S
H
L
P
S
F
P
S
R
F
V
I
G
R
S
Site 126
Y1453
R
R
E
E
L
N
G
Y
I
W
H
L
I
H
A
Site 127
S1487
D
E
K
A
M
G
T
S
P
A
P
K
S
S
D
Site 128
S1492
G
T
S
P
A
P
K
S
S
D
G
T
W
A
R
Site 129
T1496
A
P
K
S
S
D
G
T
W
A
R
P
V
G
K
Site 130
S1511
V
G
G
E
V
K
L
S
I
S
Y
K
N
N
K
Site 131
Y1541
D
G
N
D
P
D
P
Y
V
K
I
Y
L
L
P
Site 132
Y1545
P
D
P
Y
V
K
I
Y
L
L
P
D
P
Q
K
Site 133
T1553
L
L
P
D
P
Q
K
T
T
K
R
K
T
K
V
Site 134
T1558
Q
K
T
T
K
R
K
T
K
V
A
R
K
T
C
Site 135
T1564
K
T
K
V
A
R
K
T
C
N
P
T
Y
N
E
Site 136
Y1569
R
K
T
C
N
P
T
Y
N
E
M
L
V
Y
D
Site 137
Y1575
T
Y
N
E
M
L
V
Y
D
G
I
P
K
G
D
Site 138
S1591
Q
Q
R
E
L
Q
L
S
V
L
S
E
Q
G
F
Site 139
T1621
L
D
L
A
Q
E
K
T
G
W
F
A
L
G
S
Site 140
S1628
T
G
W
F
A
L
G
S
R
S
H
G
T
L
_
Site 141
T1633
L
G
S
R
S
H
G
T
L
_
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation