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Updated November 2019
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Protein Info
Short Name:
MAN2B1
Full Name:
Lysosomal alpha-mannosidase
Alias:
Lysosomal acid alpha-mannosidase;Mannosidase alpha class 2B member 1;Mannosidase alpha-B
Type:
Mass (Da):
113744
Number AA:
1011
UniProt ID:
O00754
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T23
L
D
S
A
G
P
W
T
M
S
R
A
L
R
P
Site 2
S25
S
A
G
P
W
T
M
S
R
A
L
R
P
P
L
Site 3
Y52
A
G
A
R
A
G
G
Y
E
T
C
P
T
V
Q
Site 4
T71
N
V
H
L
L
P
H
T
H
D
D
V
G
W
L
Site 5
Y84
W
L
K
T
V
D
Q
Y
F
Y
G
I
K
N
D
Site 6
Y118
D
P
T
R
R
F
I
Y
V
E
I
A
F
F
S
Site 7
T182
G
L
R
F
L
E
D
T
F
G
N
D
G
R
P
Site 8
Y223
F
F
F
G
R
L
D
Y
Q
D
K
W
V
R
M
Site 9
S242
M
E
Q
V
W
R
A
S
T
S
L
K
P
P
T
Site 10
T243
E
Q
V
W
R
A
S
T
S
L
K
P
P
T
A
Site 11
S244
Q
V
W
R
A
S
T
S
L
K
P
P
T
A
D
Site 12
T249
S
T
S
L
K
P
P
T
A
D
L
F
T
G
V
Site 13
Y261
T
G
V
L
P
N
G
Y
N
P
P
R
N
L
C
Site 14
S284
P
L
V
E
D
P
R
S
P
E
Y
N
A
K
E
Site 15
Y287
E
D
P
R
S
P
E
Y
N
A
K
E
L
V
D
Site 16
Y307
A
T
A
Q
G
R
Y
Y
R
T
N
H
T
V
M
Site 17
T312
R
Y
Y
R
T
N
H
T
V
M
T
M
G
S
D
Site 18
T369
E
L
N
K
A
N
L
T
W
S
V
K
H
D
D
Site 19
Y380
K
H
D
D
F
F
P
Y
A
D
G
P
H
Q
F
Site 20
Y391
P
H
Q
F
W
T
G
Y
F
S
S
R
P
A
L
Site 21
S393
Q
F
W
T
G
Y
F
S
S
R
P
A
L
K
R
Site 22
Y401
S
R
P
A
L
K
R
Y
E
R
L
S
Y
N
F
Site 23
S405
L
K
R
Y
E
R
L
S
Y
N
F
L
Q
V
C
Site 24
Y406
K
R
Y
E
R
L
S
Y
N
F
L
Q
V
C
N
Site 25
S433
G
P
Y
G
S
G
D
S
A
P
L
N
E
A
M
Site 26
S450
L
Q
H
H
D
A
V
S
G
T
S
R
Q
H
V
Site 27
Y461
R
Q
H
V
A
N
D
Y
A
R
Q
L
A
A
G
Site 28
S555
D
V
V
I
F
P
S
S
D
S
Q
A
H
P
P
Site 29
S557
V
I
F
P
S
S
D
S
Q
A
H
P
P
E
L
Site 30
S600
P
Q
P
I
P
R
R
S
W
S
P
A
L
T
I
Site 31
S602
P
I
P
R
R
S
W
S
P
A
L
T
I
E
N
Site 32
T606
R
S
W
S
P
A
L
T
I
E
N
E
H
I
R
Site 33
T615
E
N
E
H
I
R
A
T
F
D
P
D
T
G
L
Site 34
Y644
V
R
Q
T
F
F
W
Y
N
A
S
I
G
D
N
Site 35
S653
A
S
I
G
D
N
E
S
D
Q
A
S
G
A
Y
Site 36
S657
D
N
E
S
D
Q
A
S
G
A
Y
I
F
R
P
Site 37
S673
Q
Q
K
P
L
P
V
S
R
W
A
Q
I
H
L
Site 38
Y704
C
S
Q
V
V
R
L
Y
P
G
Q
R
H
L
E
Site 39
S715
R
H
L
E
L
E
W
S
V
G
P
I
P
V
G
Site 40
S731
T
W
G
K
E
V
I
S
R
F
D
T
P
L
E
Site 41
T735
E
V
I
S
R
F
D
T
P
L
E
T
K
G
R
Site 42
Y744
L
E
T
K
G
R
F
Y
T
D
S
N
G
R
E
Site 43
T745
E
T
K
G
R
F
Y
T
D
S
N
G
R
E
I
Site 44
S747
K
G
R
F
Y
T
D
S
N
G
R
E
I
L
E
Site 45
Y759
I
L
E
R
R
R
D
Y
R
P
T
W
K
L
N
Site 46
T762
R
R
R
D
Y
R
P
T
W
K
L
N
Q
T
E
Site 47
T768
P
T
W
K
L
N
Q
T
E
P
V
A
G
N
Y
Site 48
Y775
T
E
P
V
A
G
N
Y
Y
P
V
N
T
R
I
Site 49
Y776
E
P
V
A
G
N
Y
Y
P
V
N
T
R
I
Y
Site 50
Y783
Y
P
V
N
T
R
I
Y
I
T
D
G
N
M
Q
Site 51
T792
T
D
G
N
M
Q
L
T
V
L
T
D
R
S
Q
Site 52
T795
N
M
Q
L
T
V
L
T
D
R
S
Q
G
G
S
Site 53
S798
L
T
V
L
T
D
R
S
Q
G
G
S
S
L
R
Site 54
S802
T
D
R
S
Q
G
G
S
S
L
R
D
G
S
L
Site 55
S803
D
R
S
Q
G
G
S
S
L
R
D
G
S
L
E
Site 56
S808
G
S
S
L
R
D
G
S
L
E
L
M
V
H
R
Site 57
S826
K
D
D
G
R
G
V
S
E
P
L
M
E
N
G
Site 58
S834
E
P
L
M
E
N
G
S
G
A
W
V
R
G
R
Site 59
Y879
A
P
G
G
G
A
A
Y
N
L
G
A
P
P
R
Site 60
T887
N
L
G
A
P
P
R
T
Q
F
S
G
L
R
R
Site 61
S890
A
P
P
R
T
Q
F
S
G
L
R
R
D
L
P
Site 62
S927
Q
F
A
V
G
E
D
S
G
R
N
L
S
A
P
Site 63
S932
E
D
S
G
R
N
L
S
A
P
V
T
L
N
L
Site 64
T945
N
L
R
D
L
F
S
T
F
T
I
T
R
L
Q
Site 65
T947
R
D
L
F
S
T
F
T
I
T
R
L
Q
E
T
Site 66
T955
I
T
R
L
Q
E
T
T
L
V
A
N
Q
L
R
Site 67
T972
A
S
R
L
K
W
T
T
N
T
G
P
T
P
H
Site 68
T977
W
T
T
N
T
G
P
T
P
H
Q
T
P
Y
Q
Site 69
T981
T
G
P
T
P
H
Q
T
P
Y
Q
L
D
P
A
Site 70
Y983
P
T
P
H
Q
T
P
Y
Q
L
D
P
A
N
I
Site 71
T991
Q
L
D
P
A
N
I
T
L
E
P
M
E
I
R
Site 72
S1003
E
I
R
T
F
L
A
S
V
Q
W
K
E
V
D
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation