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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
FBP2
Full Name:
Fructose-1,6-bisphosphatase isozyme 2
Alias:
D-fructose-1,6-bisphosphate 1-phosphohydrolase 2; EC 3.1.3.11; F16P2; FBPase; Fructose-1,6-bisphosphatase 2; Hexosediphosphatase; Muscle fructose-bisphosphatase
Type:
Carbohydrate Metabolism - fructose and mannose; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Phosphatase (non-protein); Carbohydrate Metabolism - pentose phosphate pathway; EC 3.1.3.11
Mass (Da):
36743
Number AA:
339
UniProt ID:
O00757
International Prot ID:
IPI00299456
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
Uniprot
OncoNet
Molecular Function:
GO:0042132
GO:0004331
GO:0000287
PhosphoSite+
KinaseNET
Biological Process:
GO:0006000
GO:0006094
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T9
T
D
R
S
P
F
E
T
D
M
L
T
L
T
R
Site 2
T13
P
F
E
T
D
M
L
T
L
T
R
Y
V
M
E
Site 3
T15
E
T
D
M
L
T
L
T
R
Y
V
M
E
K
G
Site 4
Y17
D
M
L
T
L
T
R
Y
V
M
E
K
G
R
Q
Site 5
T28
K
G
R
Q
A
K
G
T
G
E
L
T
Q
L
L
Site 6
S63
H
L
Y
G
I
A
G
S
V
N
V
T
G
D
E
Site 7
Y114
A
K
E
K
R
G
K
Y
V
V
C
F
D
P
L
Site 8
S125
F
D
P
L
D
G
S
S
N
I
D
C
L
A
S
Site 9
Y140
I
G
T
I
F
A
I
Y
R
K
T
S
E
D
E
Site 10
T143
I
F
A
I
Y
R
K
T
S
E
D
E
P
S
E
Site 11
S144
F
A
I
Y
R
K
T
S
E
D
E
P
S
E
K
Site 12
S149
K
T
S
E
D
E
P
S
E
K
D
A
L
Q
C
Site 13
Y210
I
K
K
K
G
K
I
Y
S
L
N
E
G
Y
A
Site 14
S211
K
K
K
G
K
I
Y
S
L
N
E
G
Y
A
K
Site 15
Y216
I
Y
S
L
N
E
G
Y
A
K
Y
F
D
A
A
Site 16
Y219
L
N
E
G
Y
A
K
Y
F
D
A
A
T
T
E
Site 17
Y227
F
D
A
A
T
T
E
Y
V
Q
K
K
K
F
P
Site 18
S238
K
K
F
P
E
D
G
S
A
P
Y
G
A
R
Y
Site 19
Y241
P
E
D
G
S
A
P
Y
G
A
R
Y
V
G
S
Site 20
Y245
S
A
P
Y
G
A
R
Y
V
G
S
M
V
A
D
Site 21
S248
Y
G
A
R
Y
V
G
S
M
V
A
D
V
H
R
Site 22
Y259
D
V
H
R
T
L
V
Y
G
G
I
F
L
Y
P
Site 23
Y265
V
Y
G
G
I
F
L
Y
P
A
N
Q
K
S
P
Site 24
S271
L
Y
P
A
N
Q
K
S
P
K
G
K
L
R
L
Site 25
Y280
K
G
K
L
R
L
L
Y
E
C
N
P
V
A
Y
Site 26
S321
R
V
P
L
I
L
G
S
P
E
D
V
Q
E
Y
Site 27
Y328
S
P
E
D
V
Q
E
Y
L
T
C
V
Q
K
N
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation