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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
SCD
Full Name:
Acyl-CoA desaturase
Alias:
ACOD; ACOD1; Delta-9-desaturase; EC 1.14.19.1; FADS5; Fatty acid desaturase; SCD1; SCDOS; Stearoyl-CoA desaturase
Type:
Endoplasmic reticulum; Membrane protein, integral; Lipid Metabolism - unsaturated fatty acid biosynthesis; Oxidoreductase; EC 1.14.19.1
Mass (Da):
41523
Number AA:
359
UniProt ID:
O00767
International Prot ID:
IPI00299468
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005783
GO:0016021
GO:0031965
Uniprot
OncoNet
Molecular Function:
GO:0005506
GO:0004768
PhosphoSite+
KinaseNET
Biological Process:
GO:0006633
GO:0055114
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S11
H
L
L
Q
D
D
I
S
S
S
Y
T
T
T
T
Site 2
S12
L
L
Q
D
D
I
S
S
S
Y
T
T
T
T
T
Site 3
S13
L
Q
D
D
I
S
S
S
Y
T
T
T
T
T
I
Site 4
Y14
Q
D
D
I
S
S
S
Y
T
T
T
T
T
I
T
Site 5
T15
D
D
I
S
S
S
Y
T
T
T
T
T
I
T
A
Site 6
T16
D
I
S
S
S
Y
T
T
T
T
T
I
T
A
P
Site 7
T17
I
S
S
S
Y
T
T
T
T
T
I
T
A
P
P
Site 8
T19
S
S
Y
T
T
T
T
T
I
T
A
P
P
S
R
Site 9
T21
Y
T
T
T
T
T
I
T
A
P
P
S
R
V
L
Site 10
S25
T
T
I
T
A
P
P
S
R
V
L
Q
N
G
G
Site 11
Y41
K
L
E
T
M
P
L
Y
L
E
D
D
I
R
P
Site 12
Y55
P
D
I
K
D
D
I
Y
D
P
T
Y
K
D
K
Site 13
T58
K
D
D
I
Y
D
P
T
Y
K
D
K
E
G
P
Site 14
Y59
D
D
I
Y
D
P
T
Y
K
D
K
E
G
P
S
Site 15
S66
Y
K
D
K
E
G
P
S
P
K
V
E
Y
V
W
Site 16
Y71
G
P
S
P
K
V
E
Y
V
W
R
N
I
I
L
Site 17
S80
W
R
N
I
I
L
M
S
L
L
H
L
G
A
L
Site 18
T91
L
G
A
L
Y
G
I
T
L
I
P
T
C
K
F
Site 19
T95
Y
G
I
T
L
I
P
T
C
K
F
Y
T
W
L
Site 20
S124
A
G
A
H
R
L
W
S
H
R
S
Y
K
A
R
Site 21
S127
H
R
L
W
S
H
R
S
Y
K
A
R
L
P
L
Site 22
Y128
R
L
W
S
H
R
S
Y
K
A
R
L
P
L
R
Site 23
Y151
M
A
F
Q
N
D
V
Y
E
W
A
R
D
H
R
Site 24
S173
T
H
A
D
P
H
N
S
R
R
G
F
F
F
S
Site 25
S198
P
A
V
K
E
K
G
S
T
L
D
L
S
D
L
Site 26
T199
A
V
K
E
K
G
S
T
L
D
L
S
D
L
E
Site 27
S203
K
G
S
T
L
D
L
S
D
L
E
A
E
K
L
Site 28
Y218
V
M
F
Q
R
R
Y
Y
K
P
G
L
L
M
M
Site 29
Y276
H
L
F
G
Y
R
P
Y
D
K
N
I
S
P
R
Site 30
S281
R
P
Y
D
K
N
I
S
P
R
E
N
I
L
V
Site 31
Y300
V
G
E
G
F
H
N
Y
H
H
S
F
P
Y
D
Site 32
Y306
N
Y
H
H
S
F
P
Y
D
Y
S
A
S
E
Y
Site 33
Y308
H
H
S
F
P
Y
D
Y
S
A
S
E
Y
R
W
Site 34
Y313
Y
D
Y
S
A
S
E
Y
R
W
H
I
N
F
T
Site 35
Y334
M
A
A
L
G
L
A
Y
D
R
K
K
V
S
K
Site 36
S340
A
Y
D
R
K
K
V
S
K
A
A
I
L
A
R
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation