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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PPAP2A
Full Name:
Lipid phosphate phosphohydrolase 1
Alias:
EC.3.1.3.4; Lipid phosphate phosphohydrolase 1; Lipid phosphate phosphohydrolase 1a; LLP1a; LPP1; PAP2; PAP2a; PAP-2a; PAP2a2; PAP2-alpha; PAP2alpha2; PAPalpha1; Phosphatidic acid phosphatase 2; Phosphatidic acid phosphatase 2a; Phosphatidic acid phosphatase type 2A; Phosphatidic acid phosphohydrolase type 2a; Type 2 phosphatidic acid phosphohydrolase; Type-2 phosphatidic acid phosphatase alpha
Type:
Lipid Metabolism - glycerophospholipid; Lipid Metabolism - glycerolipid; Lipid Metabolism - ether lipid; EC 3.1.3.4; Lipid Metabolism - sphingolipid; Phosphatase (non-protein)
Mass (Da):
32156
Number AA:
284
UniProt ID:
O14494
International Prot ID:
IPI00297037
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005887
GO:0005624
Uniprot
OncoNet
Molecular Function:
GO:0008195
GO:0042392
PhosphoSite+
KinaseNET
Biological Process:
GO:0007205
GO:0030521
GO:0008354
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T32
A
I
L
T
S
R
H
T
P
F
Q
R
G
V
F
Site 2
Y47
C
N
D
E
S
I
K
Y
P
Y
K
E
D
T
I
Site 3
T53
K
Y
P
Y
K
E
D
T
I
P
Y
A
L
L
G
Site 4
Y94
N
S
F
I
R
N
N
Y
I
A
T
I
Y
K
A
Site 5
Y121
S
L
T
D
I
A
K
Y
S
I
G
R
L
R
P
Site 6
Y147
K
I
N
C
S
D
G
Y
I
E
Y
Y
I
C
R
Site 7
Y150
C
S
D
G
Y
I
E
Y
Y
I
C
R
G
N
A
Site 8
Y151
S
D
G
Y
I
E
Y
Y
I
C
R
G
N
A
E
Site 9
S166
R
V
K
E
G
R
L
S
F
Y
S
G
H
S
S
Site 10
Y168
K
E
G
R
L
S
F
Y
S
G
H
S
S
F
S
Site 11
S169
E
G
R
L
S
F
Y
S
G
H
S
S
F
S
M
Site 12
Y185
C
M
L
F
V
A
L
Y
L
Q
A
R
M
K
G
Site 13
S216
V
S
I
Y
V
G
L
S
R
V
S
D
Y
K
H
Site 14
Y221
G
L
S
R
V
S
D
Y
K
H
H
W
S
D
V
Site 15
S255
D
F
F
K
E
R
T
S
F
K
E
R
K
E
E
Site 16
S264
K
E
R
K
E
E
D
S
H
T
T
L
H
E
T
Site 17
T266
R
K
E
E
D
S
H
T
T
L
H
E
T
P
T
Site 18
T267
K
E
E
D
S
H
T
T
L
H
E
T
P
T
T
Site 19
T271
S
H
T
T
L
H
E
T
P
T
T
G
N
H
Y
Site 20
T273
T
T
L
H
E
T
P
T
T
G
N
H
Y
P
S
Site 21
T274
T
L
H
E
T
P
T
T
G
N
H
Y
P
S
N
Site 22
Y278
T
P
T
T
G
N
H
Y
P
S
N
H
Q
P
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation