PhosphoNET

           
Protein Info 
   
Short Name:  NRG2
Full Name:  Pro-neuregulin-2, membrane-bound isoform
Alias:  Divergent of neuregulin-1; Don-1; HRG2; Neural- and thymus-derived activator for ErbB kinases; Neuregulin 2; NTAK; Divergent of neuregulin-1; Don-1; HRG2; Neural- and thymus-derived activator for ErbB kinases; Neuregulin 2; NTAK; Pro-NRG2
Type:  Extracellular, Plasma membrane, Integral protein
Mass (Da):  91679
Number AA:  850
UniProt ID:  O14511
International Prot ID:  IPI00477848
Sequence:  Retrieve full protein sequence
   
GO Terms  External Links Internal Links  
   
Cellular Component:  GO:0005576  GO:0016021  GO:0005886 Uniprot OncoNet
Molecular Function:  GO:0008083     PhosphoSite+ KinaseNET
Biological Process:  GO:0009790  GO:0007165   Phosida TranscriptoNet
    STRING Kinexus Products
   
Info Box  A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites 
-7-6-5-4-3-2-101234567Expt. conf.EffectKinasePPaseKinexus ProductsRef.Evol.Kinase Pred.P-site Match
Site 1S20PLEKGRCSSYSDSSS
Site 2S21LEKGRCSSYSDSSSS
Site 3Y22EKGRCSSYSDSSSSS
Site 4S23KGRCSSYSDSSSSSS
Site 5S25RCSSYSDSSSSSSER
Site 6S26CSSYSDSSSSSSERS
Site 7S27SSYSDSSSSSSERSS
Site 8S28SYSDSSSSSSERSSS
Site 9S29YSDSSSSSSERSSSS
Site 10S30SDSSSSSSERSSSSS
Site 11S33SSSSSERSSSSSSSS
Site 12S34SSSSERSSSSSSSSS
Site 13S35SSSERSSSSSSSSSE
Site 14S36SSERSSSSSSSSSES
Site 15S37SERSSSSSSSSSESG
Site 16S38ERSSSSSSSSSESGS
Site 17S39RSSSSSSSSSESGSS
Site 18S40SSSSSSSSSESGSSS
Site 19S41SSSSSSSSESGSSSR
Site 20S43SSSSSSESGSSSRSS
Site 21S45SSSSESGSSSRSSSN
Site 22S46SSSESGSSSRSSSNN
Site 23S47SSESGSSSRSSSNNS
Site 24S49ESGSSSRSSSNNSSI
Site 25S50SGSSSRSSSNNSSIS
Site 26S51GSSSRSSSNNSSISR
Site 27S54SRSSSNNSSISRPAA
Site 28S55RSSSNNSSISRPAAP
Site 29S57SSNNSSISRPAAPPE
Site 30S75QQQPQPRSPAARRAA
Site 31S85ARRAAARSRAAAAGG
Site 32Y194PLERNQRYIFFLEPT
Site 33S453CPAHQNRSLANGPSH
Site 34S459RSLANGPSHPRLDPE
Site 35Y473EEIQMADYISKNVPA
Site 36T489DHVIRRETETTFSGS
Site 37T491VIRRETETTFSGSHS
Site 38T492IRRETETTFSGSHSC
Site 39S494RETETTFSGSHSCSP
Site 40S496TETTFSGSHSCSPSH
Site 41S498TTFSGSHSCSPSHHC
Site 42S500FSGSHSCSPSHHCST
Site 43S502GSHSCSPSHHCSTAT
Site 44S506CSPSHHCSTATPTSS
Site 45T507SPSHHCSTATPTSSH
Site 46T509SHHCSTATPTSSHRH
Site 47S512CSTATPTSSHRHESH
Site 48S513STATPTSSHRHESHT
Site 49S518TSSHRHESHTWSLER
Site 50T520SHRHESHTWSLERSE
Site 51S522RHESHTWSLERSESL
Site 52S526HTWSLERSESLTSDS
Site 53S528WSLERSESLTSDSQS
Site 54T530LERSESLTSDSQSGI
Site 55S531ERSESLTSDSQSGIM
Site 56S533SESLTSDSQSGIMLS
Site 57S535SLTSDSQSGIMLSSV
Site 58S540SQSGIMLSSVGTSKC
Site 59S541QSGIMLSSVGTSKCN
Site 60S545MLSSVGTSKCNSPAC
Site 61S549VGTSKCNSPACVEAR
Site 62Y563RARRAAAYNLEERRR
Site 63T572LEERRRATAPPYHDS
Site 64Y576RRATAPPYHDSVDSL
Site 65S579TAPPYHDSVDSLRDS
Site 66S582PYHDSVDSLRDSPHS
Site 67S586SVDSLRDSPHSERYV
Site 68S589SLRDSPHSERYVSAL
Site 69Y592DSPHSERYVSALTTP
Site 70S594PHSERYVSALTTPAR
Site 71T598RYVSALTTPARLSPV
Site 72S603LTTPARLSPVDFHYS
Site 73S610SPVDFHYSLATQVPT
Site 74T613DFHYSLATQVPTFEI
Site 75T617SLATQVPTFEITSPN
Site 76T621QVPTFEITSPNSAHA
Site 77S625FEITSPNSAHAVSLP
Site 78S638LPPAAPISYRLAEQQ
Site 79Y674GADMQRSYDSYYYPA
Site 80Y677MQRSYDSYYYPAAGP
Site 81Y678QRSYDSYYYPAAGPG
Site 82Y679RSYDSYYYPAAGPGP
Site 83T690GPGPRRGTCALGGSL
Site 84S696GTCALGGSLGSLPAS
Site 85S699ALGGSLGSLPASPFR
Site 86S703SLGSLPASPFRIPED
Site 87Y713RIPEDDEYETTQECA
Site 88T716EDDEYETTQECAPPP
Site 89S733RPRARGASRRTSAGP
Site 90T736ARGASRRTSAGPRRW
Site 91S737RGASRRTSAGPRRWR
Site 92S746GPRRWRRSRLNGLAA
Site 93S762RARAARDSLSLSSGS
Site 94S764RAARDSLSLSSGSGG
Site 95S766ARDSLSLSSGSGGGS
Site 96S767RDSLSLSSGSGGGSA
Site 97S769SLSLSSGSGGGSASA
Site 98S773SSGSGGGSASASDDD
Site 99S775GSGGGSASASDDDAD
Site 100S777GGGSASASDDDADDA
Site 101S807GAHDALRSDSPPLCP
Site 102S809HDALRSDSPPLCPAA
Site 103S818PLCPAADSRTYYSLD
Site 104T820CPAADSRTYYSLDSH
Site 105Y821PAADSRTYYSLDSHS
Site 106Y822AADSRTYYSLDSHST
Site 107S823ADSRTYYSLDSHSTR
Site 108S826RTYYSLDSHSTRASS
Site 109S828YYSLDSHSTRASSRH
Site 110T829YSLDSHSTRASSRHS
Site 111S832DSHSTRASSRHSRGP
Site 112S833SHSTRASSRHSRGPP
Site 113S836TRASSRHSRGPPPRA
Site 114S847PPRAKQDSAPL____
 
Legend 
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available  
Products available
 


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