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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
NAP5
Full Name:
Nck-associated protein 5
Alias:
ERIH; ERIH1; ERIH2; NAP-5; Nck associated protein 5; Nck-associated 5; NCK-associated protein 5; Peripheral clock; Peripheral clock protein
Type:
Mass (Da):
208519
Number AA:
1909
UniProt ID:
O14513
International Prot ID:
IPI00419253
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S17
R
D
F
G
K
R
L
S
L
D
S
S
L
V
E
Site 2
S20
G
K
R
L
S
L
D
S
S
L
V
E
Y
M
D
Site 3
S21
K
R
L
S
L
D
S
S
L
V
E
Y
M
D
S
Site 4
Y25
L
D
S
S
L
V
E
Y
M
D
S
N
K
Y
I
Site 5
S28
S
L
V
E
Y
M
D
S
N
K
Y
I
E
H
L
Site 6
Y31
E
Y
M
D
S
N
K
Y
I
E
H
L
L
T
Q
Site 7
T37
K
Y
I
E
H
L
L
T
Q
L
E
E
Q
H
R
Site 8
S45
Q
L
E
E
Q
H
R
S
L
W
R
E
K
L
A
Site 9
S65
R
E
V
A
Q
R
T
S
E
G
A
M
H
E
K
Site 10
S87
E
R
H
L
R
L
Q
S
E
K
R
L
Q
E
V
Site 11
T95
E
K
R
L
Q
E
V
T
L
E
S
E
R
N
R
Site 12
S98
L
Q
E
V
T
L
E
S
E
R
N
R
I
Q
M
Site 13
S107
R
N
R
I
Q
M
R
S
L
Q
Q
Q
F
S
R
Site 14
S113
R
S
L
Q
Q
Q
F
S
R
M
E
E
T
V
R
Site 15
T118
Q
F
S
R
M
E
E
T
V
R
N
L
L
Q
S
Site 16
S125
T
V
R
N
L
L
Q
S
Q
G
S
P
E
Q
K
Site 17
S128
N
L
L
Q
S
Q
G
S
P
E
Q
K
K
E
E
Site 18
T136
P
E
Q
K
K
E
E
T
V
N
I
M
V
Y
Q
Site 19
Y142
E
T
V
N
I
M
V
Y
Q
E
K
L
S
E
E
Site 20
S147
M
V
Y
Q
E
K
L
S
E
E
E
R
K
H
K
Site 21
S168
H
M
V
V
D
E
D
S
R
S
E
S
S
S
T
Site 22
S170
V
V
D
E
D
S
R
S
E
S
S
S
T
D
E
Site 23
S172
D
E
D
S
R
S
E
S
S
S
T
D
E
G
K
Site 24
S174
D
S
R
S
E
S
S
S
T
D
E
G
K
E
K
Site 25
T175
S
R
S
E
S
S
S
T
D
E
G
K
E
K
T
Site 26
S197
K
A
L
E
A
E
N
S
A
L
A
L
E
N
E
Site 27
Y210
N
E
N
Q
R
E
Q
Y
E
R
C
L
D
E
V
Site 28
S253
E
Q
Q
N
R
T
L
S
I
L
F
Q
Q
R
V
Site 29
T263
F
Q
Q
R
V
R
P
T
S
D
L
L
L
Q
K
Site 30
S264
Q
Q
R
V
R
P
T
S
D
L
L
L
Q
K
L
Site 31
S279
H
S
R
L
L
D
L
S
S
G
D
L
L
S
E
Site 32
S285
L
S
S
G
D
L
L
S
E
V
E
R
N
R
S
Site 33
S292
S
E
V
E
R
N
R
S
L
T
Q
S
R
T
D
Site 34
T294
V
E
R
N
R
S
L
T
Q
S
R
T
D
A
E
Site 35
S296
R
N
R
S
L
T
Q
S
R
T
D
A
E
V
H
Site 36
T298
R
S
L
T
Q
S
R
T
D
A
E
V
H
E
H
Site 37
S311
E
H
Q
L
N
T
K
S
A
L
K
C
P
G
L
Site 38
S331
G
H
L
C
P
R
N
S
Y
S
S
S
S
E
L
Site 39
Y332
H
L
C
P
R
N
S
Y
S
S
S
S
E
L
S
Site 40
S333
L
C
P
R
N
S
Y
S
S
S
S
E
L
S
L
Site 41
S334
C
P
R
N
S
Y
S
S
S
S
E
L
S
L
S
Site 42
S335
P
R
N
S
Y
S
S
S
S
E
L
S
L
S
S
Site 43
S336
R
N
S
Y
S
S
S
S
E
L
S
L
S
S
T
Site 44
S339
Y
S
S
S
S
E
L
S
L
S
S
T
C
S
E
Site 45
S341
S
S
S
E
L
S
L
S
S
T
C
S
E
Y
S
Site 46
S342
S
S
E
L
S
L
S
S
T
C
S
E
Y
S
S
Site 47
T343
S
E
L
S
L
S
S
T
C
S
E
Y
S
S
G
Site 48
S345
L
S
L
S
S
T
C
S
E
Y
S
S
G
S
S
Site 49
Y347
L
S
S
T
C
S
E
Y
S
S
G
S
S
Y
T
Site 50
S348
S
S
T
C
S
E
Y
S
S
G
S
S
Y
T
W
Site 51
S349
S
T
C
S
E
Y
S
S
G
S
S
Y
T
W
H
Site 52
S352
S
E
Y
S
S
G
S
S
Y
T
W
H
D
G
K
Site 53
Y353
E
Y
S
S
G
S
S
Y
T
W
H
D
G
K
N
Site 54
S366
K
N
L
R
K
R
Q
S
S
Q
N
W
D
K
R
Site 55
S367
N
L
R
K
R
Q
S
S
Q
N
W
D
K
R
L
Site 56
S375
Q
N
W
D
K
R
L
S
I
D
S
S
L
P
S
Site 57
S378
D
K
R
L
S
I
D
S
S
L
P
S
G
F
A
Site 58
S379
K
R
L
S
I
D
S
S
L
P
S
G
F
A
S
Site 59
S382
S
I
D
S
S
L
P
S
G
F
A
S
P
T
N
Site 60
S386
S
L
P
S
G
F
A
S
P
T
N
E
L
P
P
Site 61
T388
P
S
G
F
A
S
P
T
N
E
L
P
P
T
R
Site 62
T394
P
T
N
E
L
P
P
T
R
I
K
E
S
H
I
Site 63
S438
N
S
N
E
G
I
Y
S
P
G
I
K
S
S
S
Site 64
S443
I
Y
S
P
G
I
K
S
S
S
L
K
E
Y
P
Site 65
S445
S
P
G
I
K
S
S
S
L
K
E
Y
P
P
C
Site 66
Y449
K
S
S
S
L
K
E
Y
P
P
C
K
T
A
D
Site 67
T454
K
E
Y
P
P
C
K
T
A
D
L
G
S
P
C
Site 68
S459
C
K
T
A
D
L
G
S
P
C
K
E
P
H
K
Site 69
T467
P
C
K
E
P
H
K
T
F
V
Y
D
L
D
S
Site 70
Y470
E
P
H
K
T
F
V
Y
D
L
D
S
H
V
D
Site 71
S474
T
F
V
Y
D
L
D
S
H
V
D
A
D
D
D
Site 72
S483
V
D
A
D
D
D
P
S
T
L
A
L
L
Q
A
Site 73
T484
D
A
D
D
D
P
S
T
L
A
L
L
Q
A
V
Site 74
S495
L
Q
A
V
P
N
Q
S
C
R
P
H
G
S
K
Site 75
T504
R
P
H
G
S
K
L
T
H
S
V
S
D
S
L
Site 76
S506
H
G
S
K
L
T
H
S
V
S
D
S
L
F
G
Site 77
S508
S
K
L
T
H
S
V
S
D
S
L
F
G
W
E
Site 78
S510
L
T
H
S
V
S
D
S
L
F
G
W
E
T
N
Site 79
T516
D
S
L
F
G
W
E
T
N
R
K
H
F
L
E
Site 80
S527
H
F
L
E
G
T
S
S
V
Y
P
K
E
R
P
Site 81
Y529
L
E
G
T
S
S
V
Y
P
K
E
R
P
E
K
Site 82
T538
K
E
R
P
E
K
L
T
S
C
A
S
S
C
P
Site 83
S539
E
R
P
E
K
L
T
S
C
A
S
S
C
P
L
Site 84
S542
E
K
L
T
S
C
A
S
S
C
P
L
E
M
K
Site 85
T556
K
L
C
P
S
V
Q
T
P
Q
V
Q
R
E
R
Site 86
S580
M
A
L
N
L
Q
L
S
D
T
D
D
N
E
T
Site 87
T582
L
N
L
Q
L
S
D
T
D
D
N
E
T
F
D
Site 88
T587
S
D
T
D
D
N
E
T
F
D
E
L
H
I
E
Site 89
S596
D
E
L
H
I
E
S
S
D
E
K
S
P
S
D
Site 90
S600
I
E
S
S
D
E
K
S
P
S
D
V
S
L
A
Site 91
S602
S
S
D
E
K
S
P
S
D
V
S
L
A
A
D
Site 92
S605
E
K
S
P
S
D
V
S
L
A
A
D
T
D
K
Site 93
S613
L
A
A
D
T
D
K
S
V
E
N
L
D
V
L
Site 94
S630
F
G
K
S
L
C
G
S
P
E
E
E
E
K
Q
Site 95
S642
E
K
Q
V
P
I
P
S
E
T
R
P
K
T
F
Site 96
T648
P
S
E
T
R
P
K
T
F
S
F
I
K
Q
Q
Site 97
S650
E
T
R
P
K
T
F
S
F
I
K
Q
Q
R
V
Site 98
S662
Q
R
V
V
K
R
T
S
S
E
E
C
V
T
V
Site 99
S663
R
V
V
K
R
T
S
S
E
E
C
V
T
V
I
Site 100
T668
T
S
S
E
E
C
V
T
V
I
F
D
A
E
D
Site 101
S682
D
G
E
P
I
E
F
S
S
H
Q
T
G
V
V
Site 102
T686
I
E
F
S
S
H
Q
T
G
V
V
T
V
T
R
Site 103
T690
S
H
Q
T
G
V
V
T
V
T
R
N
E
I
S
Site 104
S700
R
N
E
I
S
I
N
S
T
P
A
G
P
K
A
Site 105
T701
N
E
I
S
I
N
S
T
P
A
G
P
K
A
E
Site 106
Y729
P
R
A
A
A
R
D
Y
T
F
F
K
R
S
E
Site 107
T730
R
A
A
A
R
D
Y
T
F
F
K
R
S
E
E
Site 108
T739
F
K
R
S
E
E
D
T
E
K
N
I
P
K
D
Site 109
S755
V
D
N
V
P
R
V
S
T
E
S
F
S
S
R
Site 110
T756
D
N
V
P
R
V
S
T
E
S
F
S
S
R
T
Site 111
S758
V
P
R
V
S
T
E
S
F
S
S
R
T
V
T
Site 112
S760
R
V
S
T
E
S
F
S
S
R
T
V
T
Q
N
Site 113
S761
V
S
T
E
S
F
S
S
R
T
V
T
Q
N
P
Site 114
T763
T
E
S
F
S
S
R
T
V
T
Q
N
P
Q
Q
Site 115
T765
S
F
S
S
R
T
V
T
Q
N
P
Q
Q
Q
K
Site 116
S781
V
K
P
T
H
N
I
S
C
Q
S
N
S
R
S
Site 117
S784
T
H
N
I
S
C
Q
S
N
S
R
S
S
A
P
Site 118
S786
N
I
S
C
Q
S
N
S
R
S
S
A
P
M
G
Site 119
S788
S
C
Q
S
N
S
R
S
S
A
P
M
G
I
Y
Site 120
S789
C
Q
S
N
S
R
S
S
A
P
M
G
I
Y
Q
Site 121
Y795
S
S
A
P
M
G
I
Y
Q
K
Q
N
L
T
K
Site 122
T801
I
Y
Q
K
Q
N
L
T
K
I
P
P
R
G
K
Site 123
S809
K
I
P
P
R
G
K
S
S
P
Q
K
S
K
L
Site 124
S810
I
P
P
R
G
K
S
S
P
Q
K
S
K
L
M
Site 125
S814
G
K
S
S
P
Q
K
S
K
L
M
E
P
E
A
Site 126
T822
K
L
M
E
P
E
A
T
T
L
L
P
S
S
G
Site 127
S845
A
L
A
P
G
K
L
S
R
F
M
K
T
E
S
Site 128
T850
K
L
S
R
F
M
K
T
E
S
S
G
P
L
F
Site 129
S852
S
R
F
M
K
T
E
S
S
G
P
L
F
E
L
Site 130
S853
R
F
M
K
T
E
S
S
G
P
L
F
E
L
R
Site 131
S861
G
P
L
F
E
L
R
S
D
P
H
I
P
K
H
Site 132
S869
D
P
H
I
P
K
H
S
A
Q
L
P
H
S
S
Site 133
S875
H
S
A
Q
L
P
H
S
S
R
M
P
S
R
R
Site 134
S876
S
A
Q
L
P
H
S
S
R
M
P
S
R
R
D
Site 135
S880
P
H
S
S
R
M
P
S
R
R
D
W
V
Q
C
Site 136
S890
D
W
V
Q
C
P
K
S
Q
T
P
G
S
R
S
Site 137
T892
V
Q
C
P
K
S
Q
T
P
G
S
R
S
R
P
Site 138
S895
P
K
S
Q
T
P
G
S
R
S
R
P
A
I
E
Site 139
S897
S
Q
T
P
G
S
R
S
R
P
A
I
E
S
S
Site 140
S903
R
S
R
P
A
I
E
S
S
D
S
G
E
P
P
Site 141
S904
S
R
P
A
I
E
S
S
D
S
G
E
P
P
T
Site 142
S906
P
A
I
E
S
S
D
S
G
E
P
P
T
R
D
Site 143
S918
T
R
D
E
H
C
G
S
G
P
E
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P
L
P
D
S
G
N
R
S
T
G
R
Site 296
S1734
L
P
D
S
G
N
R
S
T
G
R
Y
L
C
Q
Site 297
T1735
P
D
S
G
N
R
S
T
G
R
Y
L
C
Q
P
Site 298
Y1738
G
N
R
S
T
G
R
Y
L
C
Q
P
D
S
P
Site 299
S1744
R
Y
L
C
Q
P
D
S
P
E
D
A
E
P
L
Site 300
S1763
S
A
L
S
A
V
S
S
M
R
A
Q
T
L
E
Site 301
T1768
V
S
S
M
R
A
Q
T
L
E
R
E
V
P
S
Site 302
S1776
L
E
R
E
V
P
S
S
T
D
G
Q
R
P
A
Site 303
S1785
D
G
Q
R
P
A
D
S
A
I
V
H
S
T
S
Site 304
S1792
S
A
I
V
H
S
T
S
D
P
I
M
T
A
R
Site 305
S1806
R
G
M
R
P
L
Q
S
R
L
P
K
P
A
S
Site 306
S1813
S
R
L
P
K
P
A
S
S
G
K
V
S
S
Q
Site 307
S1814
R
L
P
K
P
A
S
S
G
K
V
S
S
Q
K
Site 308
S1818
P
A
S
S
G
K
V
S
S
Q
K
Q
N
E
A
Site 309
T1831
E
A
E
P
R
P
Q
T
C
S
S
F
G
Y
A
Site 310
S1833
E
P
R
P
Q
T
C
S
S
F
G
Y
A
E
D
Site 311
S1834
P
R
P
Q
T
C
S
S
F
G
Y
A
E
D
P
Site 312
Y1837
Q
T
C
S
S
F
G
Y
A
E
D
P
M
A
S
Site 313
S1852
Q
P
L
P
D
W
G
S
E
V
A
A
T
G
T
Site 314
T1857
W
G
S
E
V
A
A
T
G
T
Q
D
K
A
P
Site 315
T1868
D
K
A
P
R
M
C
T
Y
S
A
S
G
G
S
Site 316
Y1869
K
A
P
R
M
C
T
Y
S
A
S
G
G
S
N
Site 317
S1870
A
P
R
M
C
T
Y
S
A
S
G
G
S
N
S
Site 318
S1872
R
M
C
T
Y
S
A
S
G
G
S
N
S
D
S
Site 319
S1875
T
Y
S
A
S
G
G
S
N
S
D
S
D
L
D
Site 320
S1877
S
A
S
G
G
S
N
S
D
S
D
L
D
Y
G
Site 321
S1879
S
G
G
S
N
S
D
S
D
L
D
Y
G
D
N
Site 322
Y1883
N
S
D
S
D
L
D
Y
G
D
N
G
F
G
A
Site 323
S1901
Q
L
V
K
A
L
K
S
A
A
P
E
I
E
T
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation