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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PTPRT
Full Name:
Receptor-type tyrosine-protein phosphatase T
Alias:
EC 3.1.3.48; KIAA0283; Protein tyrosine phosphatase, receptor type, T; Receptor-type tyrosine-protein phosphatase T; RPTPrho; RPTP-rho; R-PTP-T
Type:
Receptor protein phosphatase, tyrosine; EC 3.1.3.48
Mass (Da):
164346
Number AA:
1463
UniProt ID:
O14522
International Prot ID:
IPI00013096
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0009986
GO:0016021
GO:0005886
Uniprot
OncoNet
Molecular Function:
GO:0045294
GO:0008013
GO:0045296
PhosphoSite+
KinaseNET
Biological Process:
GO:0007156
GO:0006470
GO:0007169
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S253
R
R
F
S
A
T
V
S
V
A
D
T
A
Q
R
Site 2
Y345
H
I
V
D
S
P
N
Y
K
L
W
H
L
D
P
Site 3
T404
D
I
R
A
R
Q
L
T
L
Q
W
E
P
F
G
Site 4
Y412
L
Q
W
E
P
F
G
Y
A
V
T
R
C
H
S
Site 5
T415
E
P
F
G
Y
A
V
T
R
C
H
S
Y
N
L
Site 6
Y562
G
L
Y
P
G
T
T
Y
S
F
T
I
K
A
S
Site 7
S563
L
Y
P
G
T
T
Y
S
F
T
I
K
A
S
T
Site 8
Y794
I
K
R
R
R
N
A
Y
S
Y
S
Y
Y
L
S
Site 9
S795
K
R
R
R
N
A
Y
S
Y
S
Y
Y
L
S
Q
Site 10
Y796
R
R
R
N
A
Y
S
Y
S
Y
Y
L
S
Q
R
Site 11
S797
R
R
N
A
Y
S
Y
S
Y
Y
L
S
Q
R
K
Site 12
Y799
N
A
Y
S
Y
S
Y
Y
L
S
Q
R
K
L
A
Site 13
S801
Y
S
Y
S
Y
Y
L
S
Q
R
K
L
A
K
K
Site 14
S825
R
E
M
G
P
V
A
S
A
D
K
P
T
T
K
Site 15
S834
D
K
P
T
T
K
L
S
A
S
R
N
D
E
G
Site 16
S836
P
T
T
K
L
S
A
S
R
N
D
E
G
F
S
Site 17
S843
S
R
N
D
E
G
F
S
S
S
S
Q
D
V
N
Site 18
S844
R
N
D
E
G
F
S
S
S
S
Q
D
V
N
G
Site 19
S845
N
D
E
G
F
S
S
S
S
Q
D
V
N
G
F
Site 20
S846
D
E
G
F
S
S
S
S
Q
D
V
N
G
F
T
Site 21
S861
D
G
S
R
G
E
L
S
Q
P
T
L
T
I
Q
Site 22
T864
R
G
E
L
S
Q
P
T
L
T
I
Q
T
H
P
Site 23
T866
E
L
S
Q
P
T
L
T
I
Q
T
H
P
Y
R
Site 24
Y882
C
D
P
V
E
M
S
Y
P
R
D
Q
F
Q
P
Site 25
T901
A
D
L
L
Q
H
I
T
Q
M
K
R
G
Q
G
Site 26
Y915
G
Y
G
F
K
E
E
Y
E
A
L
P
E
G
Q
Site 27
Y940
E
N
R
N
K
N
R
Y
G
N
I
I
S
Y
D
Site 28
S945
N
R
Y
G
N
I
I
S
Y
D
H
S
R
V
R
Site 29
Y946
R
Y
G
N
I
I
S
Y
D
H
S
R
V
R
L
Site 30
Y964
D
G
D
P
H
S
D
Y
I
N
A
N
Y
I
D
Site 31
Y969
S
D
Y
I
N
A
N
Y
I
D
G
Y
H
R
P
Site 32
Y973
N
A
N
Y
I
D
G
Y
H
R
P
R
H
Y
I
Site 33
Y979
G
Y
H
R
P
R
H
Y
I
A
T
Q
G
P
M
Site 34
T982
R
P
R
H
Y
I
A
T
Q
G
P
M
Q
E
T
Site 35
Y1022
G
R
V
K
C
V
R
Y
W
P
D
D
T
E
V
Site 36
Y1030
W
P
D
D
T
E
V
Y
G
D
I
K
V
T
L
Site 37
T1052
E
Y
V
I
R
T
F
T
V
Q
K
K
G
Y
H
Site 38
Y1182
V
C
E
F
R
S
L
Y
Y
N
I
S
R
L
D
Site 39
S1186
R
S
L
Y
Y
N
I
S
R
L
D
P
Q
T
N
Site 40
T1192
I
S
R
L
D
P
Q
T
N
S
S
Q
I
K
D
Site 41
S1195
L
D
P
Q
T
N
S
S
Q
I
K
D
E
F
Q
Site 42
T1208
F
Q
T
L
N
I
V
T
P
R
V
R
P
E
D
Site 43
S1217
R
V
R
P
E
D
C
S
I
G
L
L
P
R
N
Site 44
S1230
R
N
H
D
K
N
R
S
M
D
V
L
P
L
D
Site 45
S1245
R
C
L
P
F
L
I
S
V
D
G
E
S
S
N
Site 46
Y1253
V
D
G
E
S
S
N
Y
I
N
A
A
L
M
D
Site 47
S1261
I
N
A
A
L
M
D
S
H
K
Q
P
A
A
F
Site 48
T1271
Q
P
A
A
F
V
V
T
Q
H
P
L
P
N
T
Site 49
T1278
T
Q
H
P
L
P
N
T
V
A
D
F
W
R
L
Site 50
Y1351
M
A
R
P
Q
D
G
Y
R
I
V
Q
H
L
Q
Site 51
Y1359
R
I
V
Q
H
L
Q
Y
I
G
W
P
A
Y
R
Site 52
Y1365
Q
Y
I
G
W
P
A
Y
R
D
T
P
P
S
K
Site 53
T1368
G
W
P
A
Y
R
D
T
P
P
S
K
R
S
L
Site 54
S1371
A
Y
R
D
T
P
P
S
K
R
S
L
L
K
V
Site 55
S1374
D
T
P
P
S
K
R
S
L
L
K
V
V
R
R
Site 56
Y1389
L
E
K
W
Q
E
Q
Y
D
G
R
E
G
R
T
Site 57
T1396
Y
D
G
R
E
G
R
T
V
V
H
C
L
N
G
Site 58
T1434
D
V
F
H
I
V
K
T
L
R
N
N
K
S
N
Site 59
S1440
K
T
L
R
N
N
K
S
N
M
V
E
T
L
E
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation